Details of Drug

Drug General Information (ID: D1705)
Drug Name	Vorapaxar
Drug Type	Small molecule
Drug Synonymous	Vorapaxar; 618385-01-6; Zontivity; SCH-530348; SCH530348; UNII-ZCE93644N2; CHEMBL493982; CHEBI:82702; ZCE93644N2; MK-5348; ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate; Ethyl [(1r,3ar,4ar,6r,8ar,9s,9as)-9-{(E)-2-[5-(3-Fluorophenyl)pyridin-2-Yl]ethenyl}-1-Methyl-3-Oxododecahydronaphtho[2,3-C]furan-6-Yl]carbamate; Vorapaxar [USAN:INN]; Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]etheny Click to Show/Hide
Disease Class	BA41-BA43: Myocardial infarction
Therapeutic Class	Antiplatelet Agents/Protease-Activated Receptor-1 Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C29H33FN2O4
InChI	1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
InChIKey	ZBGXUVOIWDMMJE-QHNZEKIYSA-N
Canonical SMILES	CCOC(=O)NC1CCC2C(C1)CC3C(C2C=CC4=NC=C(C=C4)C5=CC(=CC=C5)F)C(OC3=O)C
External Link
	Pubchem ID	10077130
	CAS Number	618385-01-6
	CHEBI ID	82702
	TTD ID	D0VA0I

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Vorapaxar
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[2], [3], [1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[2], [3], [1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[2], [3], [1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2], [3], [1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[2], [3], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2], [3], [1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[2], [3], [1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2], [3], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2], [3], [1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[2], [3], [1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2], [3], [1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[2], [3], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[2], [3], [1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2], [3], [1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[2], [3], [1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[2], [3], [1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2], [3], [1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2], [3], [1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[2], [3], [1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[2], [3], [1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[2], [3], [1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[2], [3], [1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[139]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[141]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [12], [152]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[153], [154], [155]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[27], [18]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[27], [18]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[2], [12], [112], [113]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2], [12], [117]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [140]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[156]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[159]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [12], [117]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[2], [12], [160], [117]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[12], [161]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 126
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1]
D0047		Alteplase	NA	NA	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[11]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[12], [13]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[2], [12], [14]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0415		Danaparoid	NA	NA	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[15], [16]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[12], [17]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[18]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[19]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[20]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[18]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[21], [22]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[23]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[24]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[12], [25], [26]
D1395		Reteplase	NA	NA	Major		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[28], [29]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[28], [29]
D1669		Urokinase	NA	NA	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[30]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[18]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[18]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[12], [31]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[18]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[18]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[18]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[32], [33], [12], [34]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[12], [15], [35]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[15]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[36], [37], [38]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[39]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[40], [41], [42]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[81]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[15], [82]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[36], [37], [38]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[36], [37], [38]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[83], [84], [85]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[36], [37], [38]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[105], [93], [94], [106], [95], [107], [99], [103], [108]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[109]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[12], [110], [111]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[83], [84], [85]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[36], [37], [38]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[36], [37], [38]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[15], [114]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[115], [116]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[39]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[36], [37], [38]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[12], [118]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[83], [84], [85]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[39]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[121], [122], [12], [123], [124], [125], [126], [94], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138]
D0711		Garlic	NA	NA	Moderate		Inter Info	[142], [143], [90], [93], [144], [94], [95], [145], [146], [99], [147], [148], [103], [149], [150]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[94], [97], [151], [99], [103]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[157]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[12], [158]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[12], [110], [111]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[121], [134], [137]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[43], [44], [45], [46], [2], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80]
D0253		Capsicum	NA	NA	Minor		Inter Info	[94]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[94], [162], [99]
D0368		Clove	NA	NA	Minor		Inter Info	[94], [163], [164], [165]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[166], [94], [167]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[119], [120]

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159	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
160	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
161	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
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