Details of Drug

Details of Drug

 Drug General Information (ID: D1619)
  Drug Name
Tranexamic acid
  Drug Type Small molecule
  Drug Synonymous
AMCA; AMCHA; AMH; Amikapron; Amstat; Anvitoff; Carxamin; Cyclocapron; Cyklokapron; Emorhalt; Exacyl; Frenolyse; Hexapromin; Hexatron; Mastop; Rikavarin; Spiramin; Tamcha; Tranex; Tranexamsaeure; Tranexan; Transamin; Transamlon; Trasamlon; Ugurol; Acide tranexamique; Acido tranexamico; Acidum tranexamicum; Tranexmic acid; Tranhexamic acid; Trans AMCHA; CL 65336; DV 79; DV79; KABI 2161; LT00159441; ALBB-006013; Acide tranexamique [INN-French]; Acido tranexamico [INN-Spanish]; Acidum tranexamicum [INN-Latin]; CL-65336; Cis-AMCHA; Cyklokapron (TN); DV-79; RP 18,429; Rikavarin (TN); Rikavarin-S; T-AMCHA; Tranexamic acid cis-form; Trans-Amcha; Trans-Tranexamic acid; Cis-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic acid (JP15/USAN/INN); Tranexamic acid [USAN:INN:BAN:JAN]; Trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester; Trans-p-(Aminomethyl)cyclohexanecarboxylic; Trans-p-(Aminomethyl)cyclohexanecarboxylic acid; Cis-4-Aminomethylcyclohexane-1-carboxylic acid; Trans-1-Aminomethylcyclohexane-4-carboxylic acid; Trans-4-(Aminomethyl)cyclohexane-carboxylic acid; Trans-4-Aminomethylcyclohexane-1-carboxylic acid; Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid; Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid; Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid; 4-(Aminomethyl)-Cyclohexanecarboxylic Acid; 4-(Aminomethyl)cyclohexanecarboxylic acid; 4-(aminomethyl)cyclohexane-1-carboxylic acid
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  Disease Class GA30: Menopausal disorder
  Therapeutic Class Antifibrinolytic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C8H15NO2
  InChI 1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
  InChIKey GYDJEQRTZSCIOI-UHFFFAOYSA-N
  Canonical SMILES C1CC(CCC1CN)C(=O)O
  External Link
Pubchem ID 5526
CAS Number 701-54-2
CHEBI ID 48669
TTD ID D05HXX

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM047  Additive thrombogenic effects
BM085  Antagonize the effect of antithrombotic agents
  Relation Graph
 Full list of drugs interacting with Tranexamic acid
      Pharmacodynamic additive effects
   Additive thrombogenic effects Drug Num:  27
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0387
 
Conjugated estrogens
 
C18H21NaO5S
 
45357473 
Major    Inter Info   
[1], [2], [3]
D0388
 
Conjugated estrogens (topical)
 
C18H21NaO5S
 
45357473 
Major    Inter Info   
[1], [2], [3]
D0487
 
Diethylstilbestrol
 
C18H20O2
 
448537 
Major    Inter Info   
[1], [2], [3]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Major    Inter Info   
[4], [2], [5]
D1740
 
Anti-inhibitor coagulant complex
 
NA
 
NA
Major    Inter Info   
[4], [1], [6]
D0261
 
Carfilzomib
 
C40H57N5O7
 
11556711 
Major    Inter Info   
[7], [8], [9]
D0484
 
Dienestrol (topical)
 
C18H18O2
 
667476 
Major    Inter Info   
[1], [2], [3]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Major    Inter Info   
[4], [2], [5]
D0605
 
Esterified estrogens
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Major    Inter Info   
[1], [2], [3]
D0607
 
Estradiol (topical)
 
C18H24O2
 
5757 
Major    Inter Info   
[1], [2], [3]
D0608
 
Estramustine
 
C23H31Cl2NO3
 
259331 
Major    Inter Info   
[1], [2], [3]
D0609
 
Estrone
 
C18H22O2
 
5870 
Major    Inter Info   
[1], [2], [3]
D0610
 
Estrone sulfate
 
C18H22O5S
 
3001028 
Major    Inter Info   
[1], [2], [3]
D0611
 
Estrone sulfate (topical)
 
C18H22O5S
 
3001028 
Major    Inter Info   
[1], [2], [3]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Major    Inter Info   
[4], [2], [5]
D0633
 
Factor IX Complex (Human)
 
NA
 
NA
Major    Inter Info   
[4], [1], [6]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Major    Inter Info   
[4], [2], [5]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Major    Inter Info   
[4], [2], [5]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Major    Inter Info   
[4], [2], [5]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Major    Inter Info   
[4], [2], [5]
D1191
 
Ospemifene
 
C24H23ClO2
 
3036505 
Major    Inter Info   
[1], [2], [3]
D1370
 
Quinestrol
 
C25H32O2
 
9046 
Major    Inter Info   
[1], [2], [3]
D1376
 
Raloxifene
 
C28H27NO4S
 
5035 
Major    Inter Info   
[1], [2], [3]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Major    Inter Info   
[1], [2], [3]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Major    Inter Info   
[1], [2], [3]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Major    Inter Info   
[10], [4], [11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antithrombotic agents Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0047
 
Alteplase
 
NA
 
NA
Moderate    Inter Info   
[4], [1], [12]
D0088
 
Anistreplase
 
NA
 
NA
Moderate    Inter Info   
[4], [1], [12]
D1395
 
Reteplase
 
NA
 
NA
Moderate    Inter Info   
[4], [1], [12]
D1506
 
Streptokinase
 
C11H19NO2
 
9815560 
Moderate    Inter Info   
[4], [1], [12]
D1550
 
Tenecteplase
 
NA
 
NA
Moderate    Inter Info   
[4], [1], [12]
D1669
 
Urokinase
 
NA
 
NA
Moderate    Inter Info   
[4], [1], [12]
References
1 Product Information. Cyklokapron (tranexamic acid). Pharmacia and Upjohn, Kalamazoo, MI.
2 van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, Doggen CJ, Rosendaal FR "The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study." BMJ 339 (2009): b2921.[PMID: 19679614]
3 Gomes MP, Deitcher SR "Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review." Arch Intern Med 164 (2004): 1965-76.[PMID: 15477430]
4 Product Information. LYSTEDA (tranexamic acid). Xanodyne Pharmaceuticals Inc, Newport, KY.
5 Lidegaard O, Lokkegaard E, Svendsen AL, Agger C "Hormonal contraception and risk of venous thromboembolism: national follow-up study." BMJ 339 (2009): b2890.[PMID: 19679613]
6 Product Information. Amicar (aminocaproic acid). Immunex Corporation, Seattle, WA.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
9 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10 Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
11 Hashimoto S, Koike T, Tatewaki W, et al. "Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage." Leukemia 8 (1994): 1113-5.[PMID: 8035603]
12 Product Information. Trasylol (aprotinin). Bayer, West Haven, CT.