Details of Drug

Drug General Information (ID: D1610)
Drug Name	Topotecan
Drug Type	Small molecule
Drug Synonymous	Hycamptamine; Hycamptin; Hycamtamine; Topotecane; Topotecanum; Topotecan lactone; SKF 104864; SKF-S 104864; TOPOTECAN, HYCAMTIN; Topotecan (BAN); Topotecan [INN:BAN]; Topotecane [INN-French]; Topotecanum [INN-Latin]; Topotecan Monohydrochloride, (S)-Isomer; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-Dimethylaminomethyl-10-hydroxycamptothecin Click to Show/Hide
Disease Class	2C25: Lung cancer; 2C73: Ovarian cancer; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C23H23N3O5
InChI	1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChIKey	UCFGDBYHRUNTLO-QHCPKHFHSA-N
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
External Link
	Pubchem ID	60700
	CAS Number	123948-87-8
	CHEBI ID	63632
	TTD ID	D02PMO
	VARIDT ID	DR00044

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM011 Transporter induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Topotecan
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[117]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[117]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[117]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[117]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[117]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[117]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[117]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[117]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[117]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[117]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[117]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[117]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[117]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[117]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[117]
Affected cellular transport
	Transporter inhibition					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[10], [60], [61]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[65]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[10], [69], [49]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[73]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[10], [74]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[10], [75]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[76]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[79], [80], [17], [81], [82]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[17], [83]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[10], [84]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[87]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[88]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[89]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[17], [10], [90]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[10], [91]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[10]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[93]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[94]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[95]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[108]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[10], [110]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[17], [10], [111], [112]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[113]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[115]
	Transporter induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[10], [64]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[85], [17], [10], [86]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 160
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[13]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[17], [10], [18]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[21]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[22], [23]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[10], [24]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[17], [26]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[22], [23]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[46]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[47]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[8]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[27], [48], [49]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[50]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[8]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[51], [52], [53]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[8]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[17], [10]
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[8]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[8]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[8]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[8]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[8]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[8]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[17], [10], [54]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[17], [10], [54]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[8]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[8]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[8]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[8]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[8]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[8]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[8]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[8]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[8]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[8]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[55]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[8]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[8]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[8]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[8]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[8]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[8]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[8]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[8]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[8]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[8]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[8]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[8]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[8]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[8]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[8]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[8]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[8]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[8]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[59]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[8]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[8]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[8]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[8]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[8]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[8]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[8]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[8]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[8]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[8]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[8]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[8]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[8]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[8]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[8]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[8]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[8]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[8]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[8]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[8]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[8]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[8]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[8]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[8]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[8]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[8]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[8]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[8]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[77]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[78]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[8]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[78]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[8]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[8]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[8]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[8]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[8]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[8]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[8]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[8]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[8]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[8]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[8]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[8]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[8]
D0939		Lisocabtagene maraleucel	NA	NA	Moderate		Inter Info	[8]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[8]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[8]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[8]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[8]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[8]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[8]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[78]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[8]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[8]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[8]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[96]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[8]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[8]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[8]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[10], [97]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[98]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[8]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[8]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[8]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[8]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[8]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[8]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[8]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[8]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[8]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[8]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[106]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[10], [107]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[8]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[8]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[8]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Moderate		Inter Info	[8]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[8]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[109]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[8]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[8]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[8]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[8]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[8]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[8]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[8]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[8]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[114]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[8]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[8]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[8]
D1639		Trifluridine	C10H11F3N2O5	6256	Moderate		Inter Info	[8]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[8]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[8]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[8]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[8]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[8]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[17], [10], [116]
	Additive myelosuppressive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[7], [8], [9]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[7], [8], [9]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[10], [11], [12]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[7], [8], [9]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[17], [19], [20]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[25]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[17], [10], [56], [57]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[17], [10], [56], [57]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[92]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[14], [15], [16]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[14], [15], [16]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[14], [15], [16]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[14], [15], [16]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[14], [15], [16]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[27], [17], [28]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[29]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[14], [15], [16]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[14], [15], [16]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[14], [15], [16]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[58]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[27], [62], [63]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[99], [27], [17], [100], [101], [102], [62], [103], [104], [105], [63]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[27], [62], [63]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[27], [62], [63]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[66], [67], [68]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[66], [67], [68]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[70], [71], [72]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[70], [71], [72]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[70], [71], [72]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[70], [71], [72]

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