Details of Drug

Drug General Information (ID: D1596)
Drug Name	Tizanidine
Drug Type	Small molecule
Drug Synonymous	Sirdalud; Ternelin; Tizanidina; Tizanidinum; Sirdalud (TN); Tizanidina [INN-Spanish]; Tizanidine (INN); Tizanidine [INN:BAN]; Tizanidinum [INN-Latin]; Zanaflex (TN); 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole; 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine Click to Show/Hide
Disease Class	MB47: Tonus and reflex abnormality
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C9H8ClN5S
InChI	1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
InChIKey	XFYDIVBRZNQMJC-UHFFFAOYSA-N
Canonical SMILES	C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl
External Link
	Pubchem ID	5487
	CAS Number	51322-75-9
	CHEBI ID	63629
	TTD ID	D01MDT

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Tizanidine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0231		Caffeine	C8H10N4O2	2519	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[2], [4], [30], [1]
D0450		Desogestrel	C22H30O	40973	Major		Inter Info	[41], [4], [42]
D0573		Enoxacin	C15H17FN4O3	3229	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[59], [2], [3], [5], [1]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[41], [2], [3], [4], [5], [7], [1]
D1028		Methoxsalen	C12H8O4	4114	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1054		Mexiletine	C11H17NO	4178	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1525		Tacrine	C13H14N2	1935	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0022		Acyclovir	C8H11N5O3	135398513	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[41], [4], [42]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[41], [2], [3], [4], [5], [7], [1]
D0545		Echinacea	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[41], [4], [42]
D0636		Famotidine	C8H15N7O2S3	5702160	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1102		Nalidixic acid	C12H12N2O3	4421	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1131		Niclosamide	C13H8Cl2N2O4	4477	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[41], [4], [42]
D1160		Obeticholic acid	C26H44O4	447715	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1571		Thiabendazole	C10H7N3S	5430	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1721		Zileuton	C11H12N2O2S	60490	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3], [4], [5], [6], [7], [1], [8]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[204]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[32], [11], [38]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[276]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 218
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[9]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[9]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[43], [44], [45]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[9]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[9]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[9]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[9]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[71]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[9]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[9]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[9]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[71]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108], [9], [109], [110], [111], [112], [113], [114], [115]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[9]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[9]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[9]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[9]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[9]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[9]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[9]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[9]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[156], [157]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[9]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[9]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[9]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[1]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[1]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[1]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[183], [1], [184]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[1]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[1]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[1]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[1]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[183], [184], [1]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[1]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[1]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[1]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[1]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[1]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[1]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[1]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[1]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[1]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[1]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[1]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[1]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[1]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[1]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[1]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[1]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[1]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[1]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[1]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[1]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1521		Sumatriptan	C14H21N3O2S	5358	Moderate		Inter Info	[1]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[1]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[1]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[1]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[1]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[1]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[183], [1], [184]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[1]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[1]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[183], [184], [1]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[1]
D0164		Benzonatate	C30H53NO11	7699	Moderate		Inter Info	[1]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[1]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[248]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[1]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[1]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[1]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[1]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[1]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[1]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[1]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[1]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[183], [1], [184]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[1]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[1]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[1]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[1]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[1]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[251]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[183], [1], [184]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[1]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[183], [1], [184]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[183], [1], [184]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[1]
D0488		Difenoxin	C28H28N2O2	34328	Moderate		Inter Info	[183], [1], [184]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[1]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[1]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[183], [184], [1]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[1]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[255]
D0702		Frovatriptan	C14H17N3O	77992	Moderate		Inter Info	[1]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[1]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[261], [183], [262]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[1]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[1]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[264]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[1]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[1]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[1]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[183], [1], [184]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[1]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[183], [184], [1]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[1]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[1]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[183], [1], [184]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[1]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[1]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[1]
D1110		Naratriptan	C17H25N3O2S	4440	Moderate		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[1]
D1183		Opium	NA	NA	Moderate		Inter Info	[1]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[1]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[1]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[1]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[183], [184], [1]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[1]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[1]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[1]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[1]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[1]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[1]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[183], [1], [184]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[1]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[1]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1]
D1419		Rizatriptan	C15H19N5	5078	Moderate		Inter Info	[1]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[1]
D1451		Scopolamine (ophthalmic)	C17H21NO4	3000322	Moderate		Inter Info	[183], [1], [184]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[1]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[296], [11], [32]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[1]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[1]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[1]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[298]
D1675		Valerian	NA	NA	Moderate		Inter Info	[1]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[1]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[1]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[1]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[1]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[1]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[1]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[1]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[1]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[1]
D1658		Tryptophan	C11H12N2O2	6305	Moderate		Inter Info	[1]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[1]
	Additive hypotensive effects					Drug Num: 105
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1]
D0058		Amiloride	C6H8ClN7O	16231	Major		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[1]
D0117		Atenolol	C14H22N2O3	2249	Major		Inter Info	[1]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[1]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Major		Inter Info	[1]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Major		Inter Info	[1]
D0173		Betaxolol	C18H29NO3	2369	Major		Inter Info	[1]
D0188		Bisoprolol	C18H31NO4	2405	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[1]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Major		Inter Info	[1]
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[1]
D0459		Dexmedetomidine	C13H16N2	5311068	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0524		Doxazosin	C23H25N5O5	3157	Major		Inter Info	[1]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[1]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[1]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[1]
D0704		Furosemide	C12H11ClN2O5S	3440	Major		Inter Info	[1]
D0742		Guanabenz	C8H8Cl2N4	5702063	Major		Inter Info	[1]
D0743		Guanadrel	C10H19N3O2	38521	Major		Inter Info	[1]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[1]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1]
D0954		Losartan	C22H23ClN6O	3961	Major		Inter Info	[1]
D0983		Mecamylamine	C11H21N	4032	Major		Inter Info	[1]
D1048		Metolazone	C16H16ClN3O3S	4170	Major		Inter Info	[1]
D1049		Metoprolol	C15H25NO3	4171	Major		Inter Info	[1]
D1067		Milrinone	C12H9N3O	4197	Major		Inter Info	[1]
D1072		Minoxidil	C9H15N5O	4201	Major		Inter Info	[1]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[1]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[1]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[1]
D1147		Nitroprusside	C5FeN6O	11953891	Major		Inter Info	[1]
D1170		Olmesartan	C24H26N6O3	158781	Major		Inter Info	[1]
D1271		Phentolamine	C17H19N3O	5775	Major		Inter Info	[1]
D1331		Prazosin	C19H21N5O4	4893	Major		Inter Info	[1]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[1]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[1]
D1393		Reserpine	C33H40N2O9	5770	Major		Inter Info	[1]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[1]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[1]
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Major		Inter Info	[1]
D0053		Ambrisentan	C22H22N2O4	6918493	Major		Inter Info	[1]
D0082		Amrinone	C10H9N3O	3698	Major		Inter Info	[1]
D0083		Amyl Nitrite	C5H11NO2	10026	Major		Inter Info	[1]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Major		Inter Info	[1]
D0217		Bumetanide	C17H20N2O5S	2471	Major		Inter Info	[1]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[1]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[1]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Major		Inter Info	[1]
D0352		Clevidipine	C21H23Cl2NO6	153994	Major		Inter Info	[1]
D0396		Cyclandelate	C17H24O3	2893	Major		Inter Info	[1]
D0444		Deserpidine	C32H38N2O8	8550	Major		Inter Info	[1]
D0474		Diazoxide	C8H7ClN2O2S	3019	Major		Inter Info	[1]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[1]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1]
D0587		Eprosartan	C23H24N2O4S	5281037	Major		Inter Info	[1]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Major		Inter Info	[1]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[1]
D0644		Fenoldopam	C16H16ClNO3	3341	Major		Inter Info	[1]
D0744		Guanethidine	C10H22N4	3518	Major		Inter Info	[1]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[1]
D0770		Hydralazine	C8H8N4	3637	Major		Inter Info	[1]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Major		Inter Info	[1]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Major		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1]
D0798		Indapamide	C16H16ClN3O3S	3702	Major		Inter Info	[1]
D0844		Irbesartan	C25H28N6O	3749	Major		Inter Info	[1]
D0860		Isosorbide	C6H10O4	12597	Major		Inter Info	[1]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Major		Inter Info	[1]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Major		Inter Info	[1]
D0864		Isoxsuprine	C18H23NO3	3783	Major		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[1]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[1]
D1035		Methyldopa	C10H13NO4	38853	Major		Inter Info	[1]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[1]
D1114		Nebivolol	C22H25F2NO4	71301	Major		Inter Info	[1]
D1125		Nesiritide	C143H244N50O42S4	53325981	Major		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[1]
D1146		Nitroglycerin	C3H5N3O9	4510	Major		Inter Info	[1]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[1]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[1]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[1]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Major		Inter Info	[1]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Major		Inter Info	[1]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[1]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[1]
D1545		Telmisartan	C33H30N4O2	65999	Major		Inter Info	[1]
D1552		Terazosin	C19H25N5O4	5401	Major		Inter Info	[1]
D1602		Tolazoline	C10H12N2	5504	Major		Inter Info	[1]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Major		Inter Info	[1]
D1643		Trimethaphan	C22H25N2OS+	23576	Major		Inter Info	[1]
D1611		Torasemide	C16H20N4O3S	41781	Major		Inter Info	[1]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[1]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[1]
D1679		Valsartan	C24H29N5O3	60846	Major		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[182], [1]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[188], [1], [189]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[188], [1], [189]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[188], [1], [189]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[31], [32], [11], [272], [38]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[274]
	Additive neuromuscular blocking effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[185], [186], [187]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[185], [186], [187]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[11], [129], [198]
	Increased risk of hepatotoxicity					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[137]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[142]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[146]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[31], [164], [165]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[190]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[194], [195], [196], [197]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[194], [195], [196], [197]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [199]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[202], [203]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[236], [237], [238], [32], [11], [239], [240], [241], [242], [243], [244], [245], [246]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[247]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[236], [237], [238], [32], [11], [239], [240], [241], [242], [243], [244], [245], [246]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[260]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[275]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[194], [195], [196], [197]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [297]
	Increased risk of prolong QT interval					Drug Num: 122
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[31], [32], [11], [33], [34], [35]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[31], [32], [11], [36], [37], [38], [39]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[31], [32], [11], [40], [38]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[31], [32], [11], [46], [47], [48], [49], [50], [51], [52], [53], [54], [38]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[31], [32], [11], [55]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[31], [32], [11], [56], [57], [38]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[58]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[60], [31], [32], [11], [61], [62], [63]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[31], [32], [11], [64], [65], [66], [67], [68], [69], [38]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[31], [32], [11], [70]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[72], [60], [73], [31], [32], [11], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[31], [32], [11], [94], [56], [95], [96], [97], [38]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[98]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[31], [32], [11], [46], [47], [48], [49], [50], [51], [52], [53], [54], [38]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[11], [116]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[31], [32], [11], [117]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[118]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[31], [32], [11], [119]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[31], [32], [11], [120]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[31], [121], [32], [11], [122], [123], [38]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[72], [60], [73], [31], [32], [11], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[125], [31], [32], [11], [126], [127], [128], [129], [130]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[31], [32], [11], [131], [38]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[134]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[135]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[11], [136], [38]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[32], [11], [138]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[139]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[31], [32], [11], [140], [38]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[31], [32], [11], [141]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[31], [32], [11], [143]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[145]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[11], [56], [147], [38]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[31], [32], [11], [46], [47], [48], [49], [50], [51], [52], [53], [54], [38]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[31], [32], [11], [56], [78], [148], [149], [38]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[150], [151], [31], [32], [11], [152], [153]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[11], [154]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[60], [31], [32], [11], [158], [159], [76], [78], [80], [160], [81], [82], [161], [84], [85], [86], [87], [162], [91], [63], [163]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[31], [32], [11], [166]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[31], [32], [11], [167]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[31], [32], [11], [56], [168], [38]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[78], [149], [38]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[200], [201]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[31], [32], [11], [235], [38]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[249]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[250]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[252]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[32], [11], [253]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[31], [32], [11], [254]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[256]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[60], [80], [81], [86], [257]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[258]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[259]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[11], [263]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[60], [31], [32], [11], [76], [77], [78], [265], [266], [81], [82], [267], [83], [268], [84], [85], [86], [87], [269], [270], [271], [91], [63]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[11]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[31], [32], [273]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[60], [31], [32], [11], [76], [77], [78], [265], [266], [81], [82], [267], [83], [268], [84], [85], [86], [87], [269], [270], [271], [91], [63]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[277]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[280], [281], [282], [283], [284], [285], [286], [287], [288], [289]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[11], [169], [170], [171], [172], [173], [174], [175]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[31], [32], [11], [290]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[31], [32], [11], [291]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[31], [32], [11], [292], [293], [294]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[31], [32], [11], [295], [38]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[299], [300], [301], [302], [303], [304], [38]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[31], [32], [11], [56], [78], [149], [38]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[32], [305], [306], [307]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[31], [32], [11], [308], [309], [310], [311]
	Increased risk of ventricular arrhythmias					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[99], [100]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[31], [32], [11], [124], [39]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[11], [132], [133]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[144]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[32], [155]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[31], [176], [32], [11], [177], [178], [179], [33], [180], [181]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[31], [32], [11], [191], [192], [193]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[31], [32], [11], [191], [192], [193]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[218], [228], [231]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[218], [228], [231]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[218], [228], [231]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[11], [278], [279]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[31], [32], [11], [191], [192], [193]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[218], [228], [231]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[11], [278], [279]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[218], [228], [231]

References
1	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
2	Granfors MT, Backman JT, Laitila J, Neuvonen PJ "Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro." Br J Clin Pharmacol 57 (2004): 349-53. [PMID: 14998432]
3	Granfors MT, Backman JT, Neuvonen M, Ahonen J, Neuvonen PJ "Fluvoxamine drastically increases concentrations and effects of tizanidine: A potentially hazardous interaction." Clin Pharmacol Ther 75 (2004): 331-41. [PMID: 15060511]
4	Granfors MT, Backman JT, Neuvonen M, Neuvonen PJ "Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism." Clin Pharmacol Ther 76 (2004): 598-606. [PMID: 15592331]
5	Momo K, Doki K, Hosono H, Homma M, Kohda Y "Drug interaction of tizanidine and fluvoxamine." Clin Pharmacol Ther 76 (2004): 509-10. [PMID: 15536467]
6	Momo K, Homma M, Kohda Y, Ohkoshi N, Yoshizawa T, Tamaoka A "Drug interaction of tizanidine and ciprofloxacin: Case report." Clin Pharmacol Ther 80 (2006): 717-9. [PMID: 17178273]
7	Product Information. Vioxx (rofecoxib). Merck & Co, Inc, West Point, PA.
8	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
9	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
10	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
11	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
12	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
13	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
14	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
15	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
16	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
17	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
18	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
19	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
20	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
21	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
22	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
23	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
24	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
25	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
26	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
27	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
28	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
29	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
30	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
31	Canadian Pharmacists Association.
32	Cerner Multum, Inc. "Australian Product Information.".
33	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
34	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
35	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
36	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
37	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
38	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
39	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
40	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
41	Granfors MT, Backman JT, Laitila J, Neuvonen PJ "Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2." Clin Pharmacol Ther 78 (2005): 400-11. [PMID: 16198659]
42	Product Information. Vioxx (rofecoxib). Merck &amp Co, Inc, West Point, PA.
43	Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
44	Peterson GR, Covault HP, Hostetler RM "Acute inhibition of microsomal drug metabolism by propoxphene in narcotic tolerant/dependent mice." Life Sci 22 (1978): 2087-96. [PMID: 566834]
45	Abernethy DR, Greenblatt DJ, Morse DS, Shader RI "Interaction of propoxyphene with diazepam, alprazolam and lorazepam." Br J Clin Pharmacol 19 (1985): 51-7. [PMID: 2858217]
46	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
47	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
48	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
49	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
50	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
51	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
52	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
53	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
54	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
55	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
56	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
57	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
58	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
59	Brosen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S "Fluvoxamine is a potent inhibitor of cytochrome P4501A2." Biochem Pharmacol 45 (1993): 1211-4. [PMID: 8466541]
60	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
61	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
62	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
63	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
64	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
65	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
66	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
67	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
68	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
69	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
70	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
71	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
72	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
73	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
74	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
75	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
76	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
77	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
78	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
79	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
80	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
81	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
82	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
83	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
84	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
85	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
86	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
87	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
88	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
89	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
90	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
91	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
92	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
93	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
94	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
95	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
96	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
97	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
98	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
99	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
100	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
101	Sekar M, Mimpriss TJ "Buprenorphine, benzodiazepines and prolonged respiratory depression." Anaesthesia 42 (1987): 567-8. [PMID: 3592200]
102	Pirnay S, Borron SW, Giudicelli CP, Tourneau J, Baud FJ, Ricordel I "A critical review of the causes of death among post-morten toxicological investigations: analysis of 34 buprenorphine-associated and 35 methadone-associated deaths." Addiction 99 (2004): 978-88. [PMID: 15265095]
103	Schuman-Olivier Z, Hoeppner BB, Weiss RD, Borodovsky J, Shaffer HJ, Albanese MJ "Benzodiazepine use during buprenorphine treatment for opioid dependence: clinical and safety outcomes." Drug Alcohol Depend 132 (2013): 580-6. [PMID: 23688843]
104	Reynaud M, Petit G, Potard D, Courty P "Six deaths linked to concomitant use of buprenorphine and benzodiazepines." Addiction 93 (1998): 1385-92. [PMID: 9926544]
105	Kintz P "A new series of 13 buprenorphine-related deaths." Clin Biochem 35 (2002): 513-6. [PMID: 12493578]
106	Kilicarslan T, Sellers EM "Lack of interaction of buprenorphine with flunitrazepam metabolism." Am J Psychiatry 157 (2000): 1164-6. [PMID: 10873929]
107	Product Information. Suboxone (buprenorphine-naloxone). Reckitt and Colman Pharmaceuticals Inc, Richmond, VA.
108	Reynaud M, Tracqui A, Petit G, Potard D, Courty P "Six deaths linked to misuse of buprenorphine-benzodiazepine combinations." Am J Psychiatry 155 (1998): 448-9. [PMID: 9501765]
109	Hakkinen M, Launiainen T, Vuori E, Ojanpera I "Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning." Eur J Clin Pharmacol 68 (2012): 301-9. [PMID: 21927835]
110	Gueye PN, Borron SW, Risede P, et al "Buprenorphine and midazolalm act in combination to depress respiration in rats." Toxicol Sci 65 (2002): 107-14. [PMID: 11752690]
111	Tracqui A, Kintz P, Ludes B "Buprenorphine-related deaths among drug addicts in France: a report on 20 fatalities." J Anal Toxicol 22 (1998): 430-4. [PMID: 9788517]
112	Martin HA "The possible consequences of combining lorazepam and buprenorphine/naloxone: a case review." J Emerg Nurs 37 (2011): 200-2. [PMID: 21397143]
113	Center for Substance Abuse Treatment.?Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2004. [PMID: 22514846]
114	Ferrant O, Papin F, Clin B, et al "Fatal poisoning due to snorting buprenorphine and alcohol consumption." Forensic Sci Int 204 (2011): e8-11. [PMID: 20554411]
115	Kintz P "Deaths involving buprenorphine: a compendium of French cases." Forensic Sci Int 121 (2001): 65-9. [PMID: 11516889]
116	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
117	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
118	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
119	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
120	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
121	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
122	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
123	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
124	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
125	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
126	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
127	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
128	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
129	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
130	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
131	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
132	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
133	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
134	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
135	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
136	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
137	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
138	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
139	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
140	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
141	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
142	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
143	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
144	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
145	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
146	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
147	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
148	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
149	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
150	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
151	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
152	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
153	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
154	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
155	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
156	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
157	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
158	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
159	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
160	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
161	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
162	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
163	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
164	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
165	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
166	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
167	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
168	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
169	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
170	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
171	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
172	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
173	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
174	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
175	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
176	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
177	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
178	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
179	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
180	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
181	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
182	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
183	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
184	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
185	Product Information. Myobloc (botulinum toxin type B) Elan Pharmaceuticals, S. San Francisco, CA.
186	Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A)). Merz Pharmaceuticals, Greensboro, NC.
187	Product Information. Dysport (abobotulinumtoxinA). Tercica Inc, Brisbane, CA.
188	Coleman AL, Robin AL, Pollack IP, Rudikoff MT, Enger C, Mayer PR "Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine." Arch Ophthalmol 108 (1990): 1264-7. [PMID: 2205182]
189	Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
190	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
191	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
192	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
193	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
194	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
195	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
196	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
197	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
198	Canadian Pharmacists Association "e-CPS."
199	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
200	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
201	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
202	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
203	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
204	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
205	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
206	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
207	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
208	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
209	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
210	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
211	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
212	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
213	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
214	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
215	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
216	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
217	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
218	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
219	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
220	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
221	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
222	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
223	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
224	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
225	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
226	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
227	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
228	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
229	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
230	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
231	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
232	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
233	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
234	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
235	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
236	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
237	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
238	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
239	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
240	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
241	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
242	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
243	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
244	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
245	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
246	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
247	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
248	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
249	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
250	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
251	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
252	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
253	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
254	Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
255	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
256	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
257	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
258	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
259	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
260	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
261	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
262	Simonian NA, Gilliam FG, Chiappa KH "Ifosfamide causes a diazepam-sensitive encephalopathy." Neurology 43 (1993): 2700-2
263	Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
264	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
265	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones." Br Med J 322 (2001): 46-7. [PMID: 11141163]
266	Kahn JB "Latest industry information on the safety profile of levofloxacin in the US." Chemotherapy 47 Suppl 3 (2001): 32-7. [PMID: 11549787]
267	Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B "Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant "clinical" event?" South Med J 99 (2006): 52-6. [PMID: 16466123]
268	Nykamp DL, Blackmon CL, Schmidt PE, Roberson AG "QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine." Ann Pharmacother 39 (2005): 543-6. [PMID: 15687478]
269	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
270	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
271	Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
272	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
273	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
274	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
275	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
276	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
277	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
278	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
279	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
280	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
281	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
282	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
283	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
284	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
285	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
286	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
287	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
288	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
289	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
290	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
291	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
292	Demolis JL, Vacheron F, Cardus S, Funck-Brentano C "Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects." Clin Pharmacol Ther 73 (2003): 242-52. [PMID: 12621389]
293	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
294	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
295	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
296	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
297	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
298	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
299	Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
300	Dattilo PB, Nordin C "Prolonged QT associated with an overdose of trazodone." J Clin Psychiatry 68 (2007): 1309-10. [PMID: 17854263]
301	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
302	Levenson JL "Prolonged QT interval after trazodone overdose." Am J Psychiatry 156 (1999): 969-70. [PMID: 10360146]
303	Mazur A, Strasberg B, Kusniec J, Sclarovsky S "QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination." Int J Cardiol 52 (1995): 27-9. [PMID: 8707432]
304	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
305	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
306	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
307	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
308	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
309	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
310	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
311	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence