Details of Drug

Drug General Information (ID: D1587)
Drug Name	Tinidazole
Drug Type	Small molecule
Drug Synonymous	Tinidazole (oral), Mission Pharmacal Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Amebicides/Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C8H13N3O4S
InChI	1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
InChIKey	HJLSLZFTEKNLFI-UHFFFAOYSA-N
Canonical SMILES	CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
External Link
	Pubchem ID	5479
	CAS Number	148159-84-6
	CHEBI ID	63627
	TTD ID	D0O4SE
	INTEDE ID	DR1596

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tinidazole
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[41], [42]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[41], [42]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[76]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[77], [78], [79]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[20]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[21], [2], [4], [22]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[23], [24], [25]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[38], [5], [39], [40]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[45], [46], [2], [4]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[21], [48], [2], [4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[49]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[23], [50], [51], [52], [24], [53], [4], [54], [55], [56], [25]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[58]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[59]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[65]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[66]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[5], [71]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[45], [46], [2], [4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[74]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[75]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[5], [80]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[81]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[38], [5], [82]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[83]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[84]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[86]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[88], [89], [90], [91], [92], [93], [94], [95], [96]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[97]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[5], [98]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[100]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[102]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[105]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[106]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[23], [50], [51], [52], [24], [53], [4], [54], [55], [56], [25]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[108], [109], [18], [4]
	Non-CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0081		Amprenavir (oral solution)	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[31], [32], [33], [34], [35], [2], [4], [36], [37]
	CYP450 enzyme induction					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[5], [12], [13]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[17], [18], [19], [2], [4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[17], [18], [19], [2], [4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[17], [18], [2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[38], [5], [43], [44]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[17], [18], [19], [2], [4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[17], [18], [19], [2], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[4]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[17], [18], [19], [2], [4]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[38], [5], [47]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[17], [18], [19], [2], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[5], [57]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[62]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[63]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[5], [64]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[38], [67]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[68], [38], [5], [69]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[70]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[85]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[87]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[17], [18], [19], [2], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[33], [4], [36]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[4]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[38], [5], [47]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[38], [5], [99], [47]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[101]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[5], [103]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[38], [72], [73]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[38], [72], [73]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[14], [15], [16]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[9], [10], [11]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[9], [10], [11]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[9], [10], [11]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[9], [10], [11]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[9], [10], [11]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[9], [10], [11]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[9], [10], [11]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[9], [10], [11]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[9], [10], [11]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[9], [10], [11]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[9], [10], [11]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[9], [10], [11]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[9], [10], [11]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9], [10], [11]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[9], [10], [11]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[9], [10], [11]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[9], [10], [11]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[9], [10], [11]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[9], [10], [11]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[9], [10], [11]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[9], [10], [11]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[9], [10], [11]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[9], [10], [11]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[9], [60], [61]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[9], [10], [11]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[9], [10], [11]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[9], [10], [11]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[9], [10], [11]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[9], [10], [11]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[9], [10], [11]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[9], [10], [11]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[9], [10], [11]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[9], [10], [11]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[9], [10], [11]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[9], [10], [11]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[9], [10], [11]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[9], [10], [11]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[9], [10], [11]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[9], [10], [11]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[9], [10], [11]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[9], [10], [11]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[9], [10], [11]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[9], [10], [11]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[9], [10], [11]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[9], [10], [11]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[9], [10], [11]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[9], [10], [11]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[9], [10], [11]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[9], [10], [11]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[9], [10], [11]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[9], [10], [11]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[14], [38], [5], [104]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[9], [10], [11]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[9], [10], [11]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[14], [107]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[9], [10], [11]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[9], [10], [11]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[9], [10], [11]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[9], [10], [11]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[3], [26], [27]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[5], [6], [7]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[8]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[28], [29], [30]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[28], [29], [30]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[28], [29], [30]

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