Drug General Information (ID: D1552)
  Drug Name
Terazosin
  Drug Type Small molecule
  Drug Synonymous
Blavin; Flumarc; Fosfomic; Hytracin; Hytrin; Terazosabb; Terazosina; Terazosine; Terazosinum; Vasomet; Trazosin HCl; A 45975; Abbott 45975; A-45975; Hytrin (TN); Terazosabb (TN); Terazosin (INN); Terazosin [INN:BAN]; Terazosina [INN-Spanish]; Terazosine [INN-French]; Terazosinum [INN-Latin]; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine; 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine; 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
    Click to Show/Hide
  Disease Class GA90: Prostate hyperplasia
  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H25N5O4
  InChI 1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
  InChIKey VCKUSRYTPJJLNI-UHFFFAOYSA-N
  Canonical SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
  External Link
Pubchem ID 5401
CAS Number 63590-64-7
CHEBI ID 9445
TTD ID D0P9RF
VARIDT ID DR00869

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM081  Increased risk of ventricular arrhythmias
BM089  Antagonize the effect of antihypertensive agents
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Terazosin
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Major    Inter Info   
[1], [2]
D1172
 
Olopatadine (nasal)
 
C21H23NO3
 
5281071 
Moderate    Inter Info   
[64], [66], [62]
D0201
 
Brexanolone
 
C21H34O2
 
92786 
Moderate    Inter Info   
[76]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[78]
   Additive hypotensive effects Drug Num:  186
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[3]
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[4]
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[5], [6], [7]
D0036
 
Alfuzosin
 
C19H27N5O4
 
2092 
Moderate    Inter Info   
[8]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[5], [6], [7]
D0055
 
Amifostine
 
C5H15N2O3PS
 
2141 
Moderate    Inter Info   
[9], [10], [11]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[5], [6], [7]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[5], [6], [7]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[9], [12], [13]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[14], [15], [16]
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[5], [6], [7]
D0156
 
Benazepril
 
C24H28N2O5
 
5362124 
Moderate    Inter Info   
[24], [10]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[25], [20], [10]
D0166
 
Benzthiazide
 
C15H14ClN3O4S3
 
2343 
Moderate    Inter Info   
[25], [20], [10]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[17], [19], [10]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[14], [15], [16]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[14], [15], [16]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[5], [6], [7]
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Moderate    Inter Info   
[5], [6], [7]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Moderate    Inter Info   
[5], [6], [7]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[5], [6], [7]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[5], [6], [7]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[5], [6], [7]
D0263
 
Carisoprodol
 
C12H24N2O4
 
2576 
Moderate    Inter Info   
[5], [6], [7]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[17], [19], [10]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[5], [6], [7]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[25], [20], [10]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[25], [20], [10]
D0327
 
Chlorzoxazone
 
C7H4ClNO2
 
2733 
Moderate    Inter Info   
[5], [6], [7]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[5], [6], [7]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[5], [6], [7]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[5], [6], [7]
D0459
 
Dexmedetomidine
 
C13H16N2
 
5311068 
Moderate    Inter Info   
[39], [40], [41]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[5], [6], [7]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[5], [6], [7]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[5], [6], [7]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[5], [6], [7]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[5], [6], [7]
D0533
 
Dronabinol
 
C21H30O2
 
16078 
Moderate    Inter Info   
[5], [6], [7]
D0567
 
Enalapril
 
C20H28N2O5
 
5388962 
Moderate    Inter Info   
[24], [10]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[10], [42]
D0644
 
Fenoldopam
 
C16H16ClNO3
 
3341 
Moderate    Inter Info   
[10], [43]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[5], [6], [7]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[5], [6], [7]
D0695
 
Fosinopril
 
C30H46NO7P
 
55891 
Moderate    Inter Info   
[24], [10]
D0745
 
Guanfacine
 
C9H9Cl2N3O
 
3519 
Moderate    Inter Info   
[39], [26], [44]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[25], [20], [10]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[5], [6], [7]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[25], [20], [10]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[5], [6], [7]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[5], [6], [7]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[26], [45], [46]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[5], [6], [7]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[25], [20], [10]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D0938
 
Lisinopril
 
C21H31N3O5
 
5362119 
Moderate    Inter Info   
[24], [10]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[5], [6], [7]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[5], [6], [7]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[5], [6], [7]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[5], [6], [7]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1023
 
Methocarbamol
 
C11H15NO5
 
4107 
Moderate    Inter Info   
[5], [6], [7]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[25], [20], [10]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[5], [6], [7]
D1848
 
Minoxidil (topical)
 
C9H15N5O
 
4201 
Moderate    Inter Info   
[60], [61]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Moderate    Inter Info   
[5], [6], [7]
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Moderate    Inter Info   
[24], [10]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[5], [6], [7]
D1090
 
Morphine (liposomal)
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[5], [6], [7]
D1096
 
Nabilone
 
C24H36O3
 
5284592 
Moderate    Inter Info   
[5], [6], [7]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[5], [6], [7]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[62], [63], [64]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[20], [10], [65]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[5], [6], [7]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[5], [6], [7]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[5], [6], [7]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[5], [6], [7]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[67]
D1256
 
Perindopril
 
C19H32N2O5
 
107807 
Moderate    Inter Info   
[24], [10]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[24], [10]
D1379
 
Ramipril
 
C23H32N2O5
 
5362129 
Moderate    Inter Info   
[24], [10]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[5], [6], [7]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Moderate    Inter Info   
[69], [70], [71]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Moderate    Inter Info   
[26], [72], [69]
D1534
 
Tamsulosin
 
C20H28N2O5S
 
129211 
Moderate    Inter Info   
[73], [69]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[5], [6], [7]
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[32], [34], [36]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0128
 
Avanafil
 
C23H26ClN7O3
 
9869929 
Moderate    Inter Info   
[74], [75]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[5], [6], [7]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[39], [26], [77]
D0254
 
Captopril
 
C9H15NO3S
 
44093 
Moderate    Inter Info   
[24], [10]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0311
 
Chloral hydrate
 
C2H3Cl3O2
 
2707 
Moderate    Inter Info   
[5], [6], [7]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[5], [6], [7]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[39], [26], [77]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[5], [6], [7]
D0471
 
Diamorphine
 
C21H23NO5
 
5462328 
Moderate    Inter Info   
[5], [6], [7]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[5], [6], [7]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[39], [26], [77]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[26], [45], [46]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Moderate    Inter Info   
[17], [19], [10]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Moderate    Inter Info   
[17], [19], [10]
D0918
 
Levodopa
 
C9H11NO4
 
6047 
Moderate    Inter Info   
[9], [12], [79]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Moderate    Inter Info   
[5], [6], [7]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[26], [83], [64]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[84]
D1006
 
Mepyramine
 
C17H23N3O
 
4992 
Moderate    Inter Info   
[5], [6], [7]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Moderate    Inter Info   
[17], [19], [10]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1148
 
Nitrous acid
 
HNO2
 
24529 
Moderate    Inter Info   
[85], [86], [87]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[5], [6], [7]
D1183
 
Opium
 
NA
 
NA
Moderate    Inter Info   
[5], [6], [7]
D1188
 
Orphenadrine
 
C18H23NO
 
4601 
Moderate    Inter Info   
[5], [6], [7]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[5], [6], [7]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1224
 
Paraldehyde
 
C6H12O3
 
31264 
Moderate    Inter Info   
[5], [6], [7]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[5], [6], [7]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[25], [20], [10]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[5], [6], [7]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[5], [6], [7]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Moderate    Inter Info   
[88]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[26], [45], [46]
D1466
 
Silodosin
 
C25H32F3N3O4
 
5312125 
Moderate    Inter Info   
[73], [69]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[5], [6], [7]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[17], [18], [19], [20], [10], [21], [22], [23]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[17], [19], [10]
D1618
 
Trandolapril
 
C24H34N2O5
 
5484727 
Moderate    Inter Info   
[24], [10]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [10], [57], [58]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Moderate    Inter Info   
[5], [6], [7]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[26], [45], [46]
D1633
 
Trichlormethiazide
 
C8H8Cl3N3O4S2
 
5560 
Moderate    Inter Info   
[25], [20], [10]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[5], [6], [7]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[85], [86], [90]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[91], [92], [93]
D1716
 
Zaleplon
 
C17H15N5O
 
5719 
Moderate    Inter Info   
[5], [6], [7]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Moderate    Inter Info   
[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Moderate    Inter Info   
[5], [6], [7]
D0711
 
Garlic
 
NA
 
NA
Minor    Inter Info   
[95], [96]
   Increased risk of ventricular arrhythmias Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[39], [26], [89]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  15
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Moderate    Inter Info   
[26], [27]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Moderate    Inter Info   
[26], [27]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Moderate    Inter Info   
[26], [27]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Moderate    Inter Info   
[26], [27]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[26], [59], [10]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[26], [27]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[26], [27]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Moderate    Inter Info   
[39], [26], [68]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[26], [27]
D0392
 
Corticotropin
 
C207H308N56O58S
 
16132265 
Moderate    Inter Info   
[26], [27]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Moderate    Inter Info   
[26], [27]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[26], [27]
D0926
 
Licorice
 
C42H62O16Zn
 
163463 
Moderate    Inter Info   
[80], [81], [82]
D1563
 
Tetracosactide
 
C136H210N40O31S
 
16133802 
Moderate    Inter Info   
[26], [27]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[26], [27]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[94], [10]
References
1 Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
2 Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
3 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
4 Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
5 Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6. [PMID: 2211552]
6 Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139. [PMID: 2005082]
7 Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1. [PMID: 1770159]
8 Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
9 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
10 Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
11 Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
12 Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
13 Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
14 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
15 Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
16 Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
17 Chrysant SG "Experience with terazosin administered in combination with other antihypertensive agents." Am J Med 80 (1986): 55-61. [PMID: 2872808]
18 Elliott HL, McLean K, Sumner DJ, Meredith PA, Reid JL "Immediate cardiovascular responses to oral prazosin: effects of concurrent beta-blockers." Clin Pharmacol Ther 29 (1981): 303-9. [PMID: 6110503]
19 Holtzman JL, Kaihlanen PM, Rider JA, Lewin AJ, Spindler JS, Oberlin JA "Concomitant administration of terazosin and atenolol for the treatment of essential hypertension." Arch Intern Med 148 (1988): 539-43. [PMID: 3277569]
20 Pool JL "Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials." Am Heart J 122 (1991): 926-31. [PMID: 1678924]
21 Rubin P, Jackson G, Blaschke T "Studies on the clinical pharmacology of prazosin II: the influence of indomethacin and of propranolol on the action and disposition of prazosin." Br J Clin Pharmacol 10 (1980): 33-9. [PMID: 7397054]
22 Seideman P, Grahnen A, Haglund K, Lindstrom B, Von Bahr C "Prazosin first dose phenomenon during combined treatment with a B-adrenoceptor blocker in hypertensive patients." Br J Clin Pharmacol 13 (1982): 865-70. [PMID: 7093116]
23 Stokes GS, Mennie BA, Gellatly R, Hill A "On the combination of alpha- and beta-adrenoceptor blockade in hypertension." Clin Pharmacol Ther 34 (1983): 576-82. [PMID: 6627819]
24 Baba T, Tomiyama T, Takebe K "Enhancement by an ACE inhibitor of first-dose hypotension caused by an alpha-blocker." N Engl J Med 322 (1990): 1237. [PMID: 1970122]
25 Cohen J "Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents." Am Heart J 122 (1991): 919-25. [PMID: 1678923]
26 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
27 Multum Information Services, Inc. Expert Review Panel.
28 Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
29 Fruncillo R, Gibbons W, Vlasses P, Ferguson R "Severe hypotension associated with concurrent clonidine and antipsychotic medication." Am J Psychiatry 142 (1985): 274. [PMID: 2857531]
30 Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
31 Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
32 Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
33 Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
34 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
35 Product Information. Risperdal (risperidone). Janssen Pharmaceutica, Titusville, NJ.
36 Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
37 Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
38 White WB "Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril." Arch Intern Med 146 (1986): 1833-4. [PMID: 3530167]
39 Cerner Multum, Inc. "Australian Product Information.".
40 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
41 Product Information. Precedex (dexmedetomidine) Abbott Pharmaceutical, Abbott Park, IL.
42 Kawano Y, Abe H, Kojima S, Takishita S, Omae T "Interaction of alcohol and an a1-blocker on ambulatory blood pressure in patients with essential hypertension." Am J Hypertens 13 (2000): 307-12
43 Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA.
44 Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
45 Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
46 Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
47 Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
48 De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
49 Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
50 Golwyn DH, Sevlie CP "Monoamine oxidase inhibitor hypertensive crisis headache and orthostatic hypotension." J Clin Psychopharmacol 13 (1993): 77-8. [PMID: 8486823]
51 Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
52 Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
53 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
54 Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
55 Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
56 Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
57 Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
58 Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
59 Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
60 Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5. [PMID: 3191000]
61 Product Information. Rogaine (minoxidil topical). Johnson and Johnson/McNeil Consumer, Fort Washington, PA.
62 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
63 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
64 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
65 Jee LD, Opie LH "Acute hypotensive response to nifedipine added to prazosin in treatment of hypertension." Br Med J 287 (1983): 1514
66 Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
67 Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
68 Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
69 Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
70 Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
71 Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
72 Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
73 Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
74 Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
75 Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
76 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
77 Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
78 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
79 Product Information. Stalevo 150 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
80 Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
81 Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
82 Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90
83 Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
84 Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
85 Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
86 Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
87 Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
88 Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
89 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
90 Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
91 McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76. [PMID: 2670511]
92 Pasanisi F, Elliot HL, Meredith PA, McSharry DR, Reid JL "Combined alpha adrenoceptor antagonism and calcium channel blockage in normal subjects." Clin Pharmacol Ther 36 (1984): 716-23
93 Kiss I, Farsang C "Nifedipine-prazosin interaction in patients with essential hypertension." Cardiovasc Drugs Ther 3 (1989): 413-5
94 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
95 Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
96 Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20