Details of Drug

Details of Drug

 Drug General Information (ID: D1539)
  Drug Name
Tedizolid
  Drug Type Small molecule
  Drug Synonymous
Tedizolid; Torezolid; 856866-72-3; TR-700; Da 7157; UNII-97HLQ82NGL; DA-7157; TR 700; 97HLQ82NGL; CHEBI:82717; (5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)-3-pyridyl]phenyl]-5-(hydroxymethyl)oxazolidin-2-one; Tedizolid [USAN:INN]; Tedizolid (USAN/INN); SCHEMBL440398; CHEMBL1257051; DTXSID10234975; XFALPSLJIHVRKE-GFCCVEGCSA-N; MolPort-042-624-220; AI025; BCP02830; ZINC43100956; AKOS025401974; CS-0687; NCGC00379072-02; AN-27109; AK322133; AC-27738; BC600578; HY-14855
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  Disease Class 1F28-1G0Z: Skin and skin-structure infection
  Therapeutic Class Oxazolidinone Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C17H15FN6O3
  InChI 1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
  InChIKey XFALPSLJIHVRKE-GFCCVEGCSA-N
  Canonical SMILES CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)CO)F
  External Link
Pubchem ID 11234049
CAS Number 856866-72-3
CHEBI ID 82717
TTD ID D08KBK

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM010  Transporter inhibition
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Tedizolid
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[15], [16]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[15], [16]
      Affected cellular transport
   Transporter inhibition Drug Num:  32
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[1], [2]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[3]
D0026
 
Afatinib
 
C24H25ClFN5O3
 
10184653 
Moderate    Inter Info   
[4], [8]
D0109
 
Artesunate
 
C19H28O8
 
6917864 
Moderate    Inter Info   
[4], [8]
D0181
 
Bictegravir
 
C21H18F3N3O5
 
90311989 
Moderate    Inter Info   
[4], [8], [9]
D0182
 
Binimetinib
 
C17H15BrF2N4O3
 
10288191 
Moderate    Inter Info   
[1], [4], [10]
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Moderate    Inter Info   
[4], [8]
D0438
 
Delafloxacin
 
C18H12ClF3N4O4
 
487101 
Moderate    Inter Info   
[4], [8]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[4], [8]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[4], [8]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[4], [8]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[4], [8]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Moderate    Inter Info   
[4], [8], [9]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[4], [8]
D0963
 
Lusutrombopag
 
C29H32Cl2N2O5S
 
49843517 
Moderate    Inter Info   
[14]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[4], [8]
D1140
 
Niraparib
 
C19H20N4O
 
24958200 
Moderate    Inter Info   
[4], [8]
D1177
 
Ombitasvir
 
C50H67N7O8
 
54767916 
Moderate    Inter Info   
[4], [8], [9]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[4], [8]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[4], [8]
D1407
 
Rimegepant
 
C28H28F2N6O3
 
51049968 
Moderate    Inter Info   
[20]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Moderate    Inter Info   
[4], [8]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[4], [8]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[4], [8]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[4], [8]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[4], [8]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Moderate    Inter Info   
[4], [8]
D1532
 
Talazoparib
 
C19H14F2N6O
 
135565082 
Moderate    Inter Info   
[21]
D1663
 
Ubrogepant
 
C29H26F3N5O3
 
68748835 
Moderate    Inter Info   
[22]
D1610
 
Topotecan
 
C23H23N3O5
 
60700 
Moderate    Inter Info   
[4], [8]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[4], [8]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Moderate    Inter Info   
[4], [8]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[4], [5], [6]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[7]
   Attenuated pharmacological effects (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0606
 
Estradiol
 
C18H24O2
 
5757 
Moderate    Inter Info   
[11], [12], [13]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[11], [12], [13]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[11], [12], [13]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[17], [18], [19]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
3 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 UK government "Typhoid.".
6 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
7 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
8 Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
9 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
10 Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
11 Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
12 Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
13 King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
14 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
15 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
16 Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
17 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
18 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
19 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
20 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
21 Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
22 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.