Details of Drug

Drug General Information (ID: D1532)
Drug Name	Talazoparib
Drug Type	Small molecule
Drug Synonymous	Talazoparib (BMN 673); UNII-9QHX048FRV; 9QHX048FRV; Talazoparib [USAN:INN]; Talzenna; 4pjt; 2YQ Click to Show/Hide
Disease Class	2C60-2C6Y: Breast cancer; FA21: Psoriatic arthritis
Therapeutic Class	Poly (Adp-Ribose) Polymerase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C19H14F2N6O
InChI	1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChIKey	HWGQMRYQVZSGDQ-HZPDHXFCSA-N
Canonical SMILES	CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
External Link
	Pubchem ID	135565082
	CAS Number	1207456-01-6
	TTD ID	D0GV8J
	VARIDT ID	DR00366

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Talazoparib
Affected cellular transport
	Transporter inhibition					Drug Num: 87
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[7], [8]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[7], [8]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[7], [8]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[8]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[8]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[8]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[39], [7], [8]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[8]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[8]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[8]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[7], [8]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[8]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[8]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[8]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7], [8]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[8]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[8]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[8]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[8]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[8]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7], [8]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[8]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[15], [47], [7], [48]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[8]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[8]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[8]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[7], [8]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[8]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[8]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[7], [8]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[7], [8]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[8]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[8]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[8]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[8]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[8]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[8]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[8]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[8]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[8]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[8]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[8]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[8]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[8]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[7], [8]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7], [8]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[8]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[7], [8]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[8]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[8]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[8]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[7], [8]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[61]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[8]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[7], [8]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[8]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[8]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[8]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[8]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[8]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[8]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[8]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[8]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[8]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[8]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[8]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[15], [67], [68]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[8]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[8]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[8]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[8]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[8]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[8]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[8]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[8]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[8]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[39], [7], [8]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[8]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[7], [8]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[8]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[8]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[8]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[8]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[8]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[8]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [12]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[18]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[19], [20]
D1111		Natalizumab	NA	NA	Major		Inter Info	[21]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[15], [7], [23]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [24]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [25]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[29]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[19], [20]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[30]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[26], [31], [32]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[34], [35], [36]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[15], [7]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [43]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [43]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[44]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[45]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[46]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [56]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[57]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[58]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[59]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [60]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[62]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[15], [7], [63]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[45]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[45]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[69]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[70]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[78]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[79]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[15], [7], [80]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [13], [14]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[15], [16], [17]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[22]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[33]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[15], [7], [52], [53]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[15], [7], [52], [53]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[54]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[9], [10], [11]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[9], [10], [11]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[9], [10], [11]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[9], [10], [11]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[9], [10], [11]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[26], [15], [27]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[28]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[9], [10], [11]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[9], [10], [11]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[9], [10], [11]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[26], [37], [38]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[55]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[26], [37], [38]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[71], [26], [15], [72], [73], [74], [37], [75], [76], [77], [38]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[26], [37], [38]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[26], [37], [38]
	Antagonize the effect of probiotics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[64], [65], [66]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[40], [41], [42]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[40], [41], [42]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[49], [50], [51]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[49], [50], [51]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
5	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
6	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
9	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
10	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
11	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
12	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
13	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
14	Canadian Pharmacists Association "e-CPS."
15	Cerner Multum, Inc. "Australian Product Information.".
16	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
17	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
18	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
19	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
20	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
21	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
22	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
23	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
24	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
25	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
26	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
27	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
28	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
29	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
30	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
31	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
32	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
33	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
34	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
35	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
36	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
37	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
38	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
39	Canadian Pharmacists Association.
40	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
41	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
42	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
43	Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]
44	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
45	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
46	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
47	Cerner Multum, Inc. "Canadian Product Information.".
48	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
49	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
50	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
51	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
52	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
53	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
54	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
55	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
56	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
57	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
58	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
59	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
60	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
61	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
62	AnazaoHealth Corporation "P32 Sodium Phosphate."
63	Multum Information Services, Inc. Expert Review Panel.
64	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
65	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
66	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
67	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
68	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
69	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
70	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
71	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
72	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
73	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
74	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
75	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
76	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
77	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
78	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
79	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
80	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.

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