Details of Drug

Details of Drug

 Drug General Information (ID: D1528)
  Drug Name
Tafamidis
  Drug Type Small molecule
  Drug Synonymous
TAFAMIDIS; 594839-88-0; FX-1006; 2-(3,5-Dichlorophenyl)-1,3-Benzoxazole-6-Carboxylic Acid; UNII-8FG9H9D31J; CHEBI:78538; 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid; 8FG9H9D31J; 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic Acid; C14H7Cl2NO3; 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid; Tafamidis [USAN:INN]; tafamidisum; 4his; Fx 1006; 3MI; Tafamidis (USAN/INN); SCHEMBL442508; GTPL8378; CHEMBL2103837; KS-00000TIG; DTXSID00208185; MolPort-027-352-897; BCP29089; 3096AH; ZINC43206271; BDBM50197883; AKOS017550076
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  Disease Class 2C30: Melanoma
  Therapeutic Class Transthyretin Stabilizers
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H7Cl2NO3
  InChI 1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
  InChIKey TXEIIPDJKFWEEC-UHFFFAOYSA-N
  Canonical SMILES C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
  External Link
Pubchem ID 11001318
CAS Number 594839-88-0
CHEBI ID 78538
TTD ID D04DFR

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM010  Transporter inhibition
BM019  UGT inhibition
  Relation Graph
 Full list of drugs interacting with Tafamidis
      Affected cellular transport
   Transporter inhibition Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[1], [2]
D0109
 
Artesunate
 
C19H28O8
 
6917864 
Moderate    Inter Info   
[3], [4], [5]
D0217
 
Bumetanide
 
C17H20N2O5S
 
2471 
Moderate    Inter Info   
[3], [4], [5]
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Moderate    Inter Info   
[3], [4], [5]
D0704
 
Furosemide
 
C12H11ClN2O5S
 
3440 
Moderate    Inter Info   
[3], [4], [5]
D0710
 
Ganciclovir
 
C9H13N5O4
 
135398740 
Moderate    Inter Info   
[3], [4], [5]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[3], [4], [5]
D0889
 
Lamivudine
 
C8H11N3O3S
 
60825 
Moderate    Inter Info   
[3], [4], [5]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[3], [4], [5]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[3], [4], [5]
D0963
 
Lusutrombopag
 
C29H32Cl2N2O5S
 
49843517 
Moderate    Inter Info   
[8]
D1407
 
Rimegepant
 
C28H28F2N6O3
 
51049968 
Moderate    Inter Info   
[9]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[3], [4], [5]
D1715
 
Zalcitabine
 
C9H13N3O3
 
24066 
Moderate    Inter Info   
[3], [4], [5]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[3], [4], [5]
      Affected intra/extra-hepatic metabolism
   UGT inhibition Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0011
 
Acetaminophen
 
C8H9NO2
 
1983 
Moderate    Inter Info   
[3], [4], [5]
D0133
 
Axitinib
 
C22H18N4OS
 
6450551 
Moderate    Inter Info   
[3], [4], [5]
D1745
 
Bazedoxifene
 
C30H34N2O3
 
154257 
Moderate    Inter Info   
[3], [4], [6]
D0153
 
Belinostat
 
C15H14N2O4S
 
6918638 
Moderate    Inter Info   
[7]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[3], [4], [5]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[3], [4], [5]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[3], [4], [5]
D0846
 
Irinotecan (liposomal)
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[3], [4], [5]
D1377
 
Raltegravir
 
C20H21FN6O5
 
54671008 
Moderate    Inter Info   
[3], [4], [5]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Vyndaqel (tafamidis). Pfizer U.S. Pharmaceuticals Group, New York, NY.
5 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
6 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
7 Product Information. Beleodaq (belinostat). Spectrum Pharmaceuticals Inc, Irvine, CA.
8 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
9 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.