Details of Drug

Drug General Information (ID: D1472)
Drug Name	Simethicone
Drug Type	Small molecule
Drug Synonymous	Phazyme; Antifoam A; DC antifoam A; Sentry Simethicone; Mylanta Gas Relief; Gas-X; Rioplus; Mylicon Infant's Drops; Simeco; Asidopan Plus; Wydrate Plus; Riopan Plus; Sentry Simethicone Emulsion; 8050-81-5; HSDB 3906; Silicone antifoam agent S 184; Silicone antifoam emulsions SE 6 and SE 9; alpha-(Trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide; Disflatyl; Sab Simplex; Simethicone [USAN]; Simethicone [USAN:USP]; SIMETICONE; AC1O5GCS; SCHEMBL339371; LS-145411; FT-0674588; 24135-EP2305254A1 Click to Show/Hide
Disease Class	MD92: Dyspepsia
Therapeutic Class	Gi Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H18O4Si3
InChI	1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;
InChIKey	AMTWCFIAVKBGOD-UHFFFAOYSA-N
Canonical SMILES	CO[Si](C)(C)O[Si](C)(C)C.O=[Si]=O
External Link
	Pubchem ID	6433516
	CAS Number	8050-81-5
	TTD ID	D01XRP

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption BM003 Complex formation
Relation Graph

Full list of drugs interacting with Simethicone
Affected gastrointestinal absorption
	Complex formation					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[7], [8], [9]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[7], [8], [9]

References
1	Campbell NR, Hasinoff BB, Stalts H, Rao B, Wong NC "Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism." Ann Intern Med 117 (1992): 1010-3. [PMID: 1443969]
2	Canadian Pharmacists Association.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Csako G, McGriff NJ, Rotman-Pikielny P, Sarlis NJ, Pucino F "Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders." Ann Pharmacother 35 (2001): 1578-83. [PMID: 11793625]
6	Liel Y, Sperber AD, Shany S "Nonspecific intestinal adsorption of levothyroxine by aluminum hydroxide." Am J Med 97 (1994): 363-5. [PMID: 7942938]
7	Neafsey PJ "Levothyroxine and calcium interaction: timing is everything." Home Healthc Nurse 22 (2004): 338-9. [PMID: 15131426]
8	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
9	Schneyer CR "Calcium carbonate and reduction of levothyroxine efficacy." JAMA 279 (1998): 750. [PMID: 9508149]
10	Singh N, Singh PN, Hershman JM "Effect of calcium carbonate on the absorption of levothyroxine." JAMA 283 (2000): 2822-5. [PMID: 10838651]
11	Sperber AD, Liel Y "Evidence for interference with the intestinal absorption of levothyroxine sodium by aluminum hydroxide." Arch Intern Med 152 (1992): 183-4. [PMID: 1728914]