Details of Drug

Details of Drug

 Drug General Information (ID: D1467)
  Drug Name
Siltuximab
  Drug Type Monoclonal antibody
  Disease Class 3A00-3A9Z: Anemia; 2A83: Multiple myeloma
  Therapeutic Class Interleukin Inhibitors
  External Link
TTD ID D07NJN

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM016  Altered formation of CYP450 enzymes
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
BM106  Diminish the response to diagnostic skin test antigens
BM110  Antagonize the effects of immunosuppressants
  Relation Graph
 Full list of drugs interacting with Siltuximab
      Affected intra/extra-hepatic metabolism
   Altered formation of CYP450 enzymes Drug Num:  60
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0064
 
Aminophylline
 
C16H24N10O4
 
9433 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0069
 
Amlodipine
 
C20H25ClN2O5
 
2162 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0450
 
Desogestrel
 
C22H30O
 
40973 
Moderate    Inter Info   
[32], [34], [37]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[32], [34], [37]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[32], [34], [37]
D0620
 
Ethosuximide
 
C7H11NO2
 
3291 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0640
 
Felodipine
 
C18H19Cl2NO4
 
3333 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0865
 
Isradipine
 
C19H21N3O5
 
3784 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0927
 
Lidocaine
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Moderate    Inter Info   
[32], [34], [37]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[32], [34], [37]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[32], [34], [37]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[32], [34], [37]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1130
 
Nicardipine
 
C26H29N3O6
 
4474 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1138
 
Nimodipine
 
C21H26N2O7
 
4497 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1141
 
Nisoldipine
 
C20H24N2O6
 
4499 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[32], [34], [37]
D1156
 
Norgestimate
 
C23H31NO3
 
6540478 
Moderate    Inter Info   
[32], [34], [37]
D1201
 
Oxtriphylline
 
C12H21N5O3
 
656652 
Moderate    Inter Info   
[32], [34], [37]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[32], [34], [37]
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Moderate    Inter Info   
[32], [34], [37]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[32], [34], [37]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[32], [34], [37]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1570
 
Theophylline
 
C7H8N4O2
 
2153 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [33], [34], [35], [36], [4], [5], [37], [38], [39], [40]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  40
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0023
 
Adalimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0304
 
Certolizumab pegol
 
NA
 
NA
Major    Inter Info   
[1], [5], [6]
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Major    Inter Info   
[7], [8]
D0614
 
Etanercept
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[12]
D0736
 
Golimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0802
 
Infliximab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[13], [14]
D1111
 
Natalizumab
 
NA
 
NA
Major    Inter Info   
[15]
D0146
 
Baricitinib
 
C16H17N7O2S
 
44205240 
Major    Inter Info   
[9], [7], [19]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[7], [20]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[9], [21]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Major    Inter Info   
[25]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[13], [14]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Major    Inter Info   
[26]
D0032
 
Alefacept
 
NA
 
NA
Moderate    Inter Info   
[22], [27], [28]
D0033
 
Alemtuzumab
 
NA
 
NA
Moderate    Inter Info   
[29]
D0085
 
Anakinra
 
C20H23N5O7S2
 
146171046 
Moderate    Inter Info   
[31], [34], [41]
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Moderate    Inter Info   
[9], [7]
D0246
 
Canakinumab
 
NA
 
NA
Moderate    Inter Info   
[31], [34], [41]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D0443
 
Denosumab
 
NA
 
NA
Moderate    Inter Info   
[42]
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[43]
D0553
 
Efalizumab
 
NA
 
NA
Moderate    Inter Info   
[44]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[46]
D1403
 
Rilonacept
 
NA
 
NA
Moderate    Inter Info   
[31], [34], [41]
D1422
 
Roflumilast
 
C17H14Cl2F2N2O3
 
449193 
Moderate    Inter Info   
[7], [47]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[43]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[43]
D1162
 
Ocrelizumab
 
NA
 
NA
Moderate    Inter Info   
[56]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1671
 
Ustekinumab
 
NA
 
NA
Moderate    Inter Info   
[38]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[7], [31], [39]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[7], [30], [27], [31], [32], [34], [38], [39], [40]
   Additive myelosuppressive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0433
 
Deferiprone
 
C7H9NO2
 
2972 
Major    Inter Info   
[9], [10], [11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  23
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1849
 
Mumps virus strain B level jeryl lynn live antigen
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1881
 
Rotavirus vaccine
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1882
 
Rubella virus vaccine
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[22], [9], [23]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Major    Inter Info   
[24]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1922
 
Yellow Fever Vaccine
 
NA
 
NA
Major    Inter Info   
[16], [17], [18]
D1838
 
Lyme disease vaccine (recombinant OspA)
 
NA
 
NA
Moderate    Inter Info   
[45]
D0089
 
Anthrax vaccine
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0366
 
Clostridium tetani toxoid antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0755
 
Hepatitis A Vaccine
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0756
 
Hepatitis B Vaccine (Recombinant)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0767
 
Human papillomavirus type 11 L1 capsid protein antigen
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0803
 
Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0804
 
Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D0999
 
Meningococcal polysaccharide vaccine group C
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D1259
 
Pfizer-BioNTech Covid-19 Vaccine
 
NA
 
NA
Moderate    Inter Info   
[57], [22], [9], [58], [59], [60], [48], [61], [62], [63], [49]
D1307
 
Poliovirus type 1 antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D1662
 
Typhoid vaccine (inactivated)
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
D1692
 
Vibrio cholerae CVD 103-HgR strain live antigen
 
NA
 
NA
Moderate    Inter Info   
[22], [48], [49]
   Antagonize the effect of probiotics Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[53], [54], [55]
   Diminish the response to diagnostic skin test antigens Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1755
 
Candida albicans
 
C29H27N2O12P
 
118855431 
Moderate    Inter Info   
[50], [51], [52]
D1765
 
Coccidioides immitis spherule
 
NA
 
NA
Moderate    Inter Info   
[50], [51], [52]
D1912
 
Trichophyton mentagrophytes
 
NA
 
NA
Moderate    Inter Info   
[50], [51], [52]
D1913
 
Tuberculin purified protein derivative
 
NA
 
NA
Moderate    Inter Info   
[50], [51], [52]
   Antagonize the effects of immunosuppressants Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0545
 
Echinacea
 
NA
 
NA
Minor    Inter Info   
[64], [65], [66]
D1722
 
Zinc acetate
 
C4H6O4Zn
 
11192 
Minor    Inter Info   
[64], [65], [66]
D1723
 
Zinc chloride
 
Cl2Zn
 
5727 
Minor    Inter Info   
[64], [65], [66]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Minor    Inter Info   
[64], [65], [66]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Minor    Inter Info   
[64], [65], [66]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Minor    Inter Info   
[64], [65], [66]
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