Details of Drug

Details of Drug

 Drug General Information (ID: D1462)
  Drug Name
Sevelamer
  Drug Type Small molecule
  Drug Synonymous
Sevelamer; 52757-95-6; 2-(chloromethyl)oxirane;prop-2-en-1-amine; Sevelamer anhydrous; Sevelamer (INN); SCHEMBL726092; 3-(Trifluoromethoxy)cinnamicacid; CHEMBL1201798; DB00658; NCGC00522026-01; D08512; 2-Propen-1-amine - 2-(chloromethyl)oxirane (1:1); 2-Propen-1-amine Hydrochloride polymer with 2-(Chloromethyl)oxirane
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  Therapeutic Class Phosphate Binders
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C6H12ClNO
  InChI InChI=1S/C3H5ClO.C3H7N/c4-1-3-2-5-3;1-2-3-4/h3H,1-2H2;2H,1,3-4H2
  InChIKey ZNSIZMQNQCNRBW-UHFFFAOYSA-N
  Canonical SMILES C=CCN.C1C(O1)CCl
  External Link
Pubchem ID 3085017

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM007  Pharmacodynamic antagonistic effects
BM003  Complex formation
BM008  Altered Fat-soluble drugs absorption
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Sevelamer
      Affected gastrointestinal absorption
   Complex formation Drug Num:  23
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[8]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[2], [3], [9], [10]
D0573
 
Enoxacin
 
C15H17FN4O3
 
3229 
Moderate    Inter Info   
[8]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[8]
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[3], [11]
D0934
 
Liothyronine
 
C15H12I3NO4
 
5920 
Moderate    Inter Info   
[3], [11]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Moderate    Inter Info   
[8]
D0340
 
Cinoxacin
 
C12H10N2O5
 
2762 
Moderate    Inter Info   
[8]
D0438
 
Delafloxacin
 
C18H12ClF3N4O4
 
487101 
Moderate    Inter Info   
[8]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Moderate    Inter Info   
[8]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[8]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[8]
D0935
 
Liotrix
 
C30H21I7N2Na2O8
 
71371 
Moderate    Inter Info   
[3], [11]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Moderate    Inter Info   
[8]
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[2], [3], [9], [10]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[2], [3], [9], [10]
D1102
 
Nalidixic acid
 
C12H12N2O3
 
4421 
Moderate    Inter Info   
[8]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Moderate    Inter Info   
[8]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[8]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Moderate    Inter Info   
[8]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[2], [3], [9], [10]
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[3], [11], [12]
D1657
 
Trovafloxacin
 
C20H15F3N4O3
 
62959 
Moderate    Inter Info   
[8]
   Altered Fat-soluble drugs absorption Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0233
 
Calcifediol
 
C27H44O2
 
5283731 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D0234
 
Calcitriol
 
C27H44O3
 
5280453 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D0328
 
Cholecalciferol
 
C27H44O
 
5280795 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D0591
 
Ergocalciferol
 
C28H44O
 
5280793 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D0495
 
Dihydrotachysterol
 
C28H46O
 
5311071 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D0527
 
Doxercalciferol
 
C28H44O2
 
5281107 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D1226
 
Paricalcitol
 
C27H44O3
 
5281104 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D1284
 
Phylloquinone
 
C31H46O2
 
5284607 
Moderate    Inter Info   
[2], [3], [7]
D1702
 
Vitamin A
 
C20H30O
 
445354 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Moderate    Inter Info   
[2], [3], [4], [5], [6], [7]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Major    Inter Info   
[1]
References
1 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
2 Cerner Multum, Inc. "Australian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
5 Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
6 Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
7 Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
8 Kays MB, Overholser BR, Mueller BA, Moe SM, Sowinski KM "Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin." Am J Kidney Dis 42 (2003): 1253-9. [PMID: 14655198]
9 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
10 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
11 Product Information. Renagel (sevelamer). Genzyme Corporation, Cambridge, MA.
12 Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]