Details of Drug

Details of Drug

 Drug General Information (ID: D1436)
  Drug Name
Sacubitril
  Drug Type Small molecule
  Drug Synonymous
Sacubitril; 149709-62-6; AHU-377; AHU377; AHU 377; 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; UNII-17ERJ0MKGI; 17ERJ0MKGI; 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; MFCD00920862; AHU-377(Sacubitril); 3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid; alpha-ethyl (alphaR,gammaS)-gamma-<(3-carboxy-1-oxopropyl)amino>-alpha-methyl<1,1'-biphenyl>-4-pentanoate; Sacubitril [USAN:INN]; Neparvis; Sacubitril (JAN/USAN/INN); AMBZ0404; GTPL7857; SCHEMBL2707112; CHEMBL3137301; AOB2046; DTXSID20164370; CHEBI:134714; 4-(((2S,4R)-1-([1,1-biphenyl]-4-yl)-5-ethoxy-4-Methyl-5-oxopentan-2-yl)aMino)-4-oxobutanoic acid; ZINC3792417; AKOS027321509; AM85599; CM14438; DB09292; NCGC00387800-02; AC-28899; AS-16703; HY-15407; D10225; J-008612; Q17811448; (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester; (2R,4S)-5-Biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid ethyl ester; (2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl) amino)-2-methylpentanoic acid ethyl ester; (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-4-biphenylpentanoic acid alpha-ethyl ester; [1,1'-Biphenyl]-4-pentanoic acid, -[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-, alpha-ethyl ester, (alphaR,S)-; [1,1'-Biphenyl]-4-pentanoic acid, gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-, alpha-ethyl ester, (alphaR,gammaS)-; AHU-377, (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester
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  Therapeutic Class Neprilysin Inhibitors
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H29NO5
  InChI InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
  InChIKey PYNXFZCZUAOOQC-UTKZUKDTSA-N
  Canonical SMILES CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
  External Link
Pubchem ID 9811834

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM048  Increased risk of angioedema/anaphylactoid reactions
  Relation Graph
 Full list of drugs interacting with Sacubitril
      Affected cellular transport
   Transporter inhibition Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[4], [5], [6]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[4], [5], [6]
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Moderate    Inter Info   
[7], [8], [9]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Moderate    Inter Info   
[7], [8], [9]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[4], [5], [6]
D1143
 
Nitisinone
 
C14H10F3NO5
 
115355 
Moderate    Inter Info   
[10], [11], [12]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Moderate    Inter Info   
[4], [5], [6]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Moderate    Inter Info   
[4], [5], [6]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[4], [5], [6]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[5], [13], [14]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[8], [9], [15]
D1471
 
Simeprevir
 
C38H47N5O7S2
 
24873435 
Moderate    Inter Info   
[7], [8], [9]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[4], [5], [6]
      Pharmacodynamic additive effects
   Increased risk of angioedema/anaphylactoid reactions Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Major    Inter Info   
[1], [2], [3]
References
1 Product Information. Micardis (telmisartan). Boehringer-Ingelheim, Ridgefield, CT.
2 ONTARGET Investigators, Yusuf S, Teo KK, et al "Telmisartan, ramipril, or both in patients at high risk for vascular events." N Engl J Med 358 (2008): 1547-59. [PMID: 18700309]
3 Product Information. Entresto (sacubitril-valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
4 Canadian Pharmacists Association.
5 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6 Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
9 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
10 Jung D, Griffy K, Dorr A "Effect of food on high-dose oral ganciclovir disposition in HIV-positive subjects." J Clin Pharmacol 39 (1999): 161-5. [PMID: 11563408]
11 Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
12 Product Information. Orfadin (nitisinone). Orphan Pharmaceuticals USA, Inc, Nashville, TN.
13 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
14 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
15 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.