Details of Drug

Details of Drug

 Drug General Information (ID: D1428)
  Drug Name
Ropivacaine
  Drug Type Small molecule
  Drug Synonymous
Naropin; ROPIVACAINE HCl; Ropivacaine hydrochloride; Ropivacaine monohydrochloride; Naropin (TN); Ropivacaine monohydrochloride, (S)-isomer; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
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  Disease Class 9A76-9A78: Corneal disease
  Therapeutic Class Anesthetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C17H26N2O
  InChI 1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1
  InChIKey ZKMNUMMKYBVTFN-HNNXBMFYSA-N
  Canonical SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
  External Link
Pubchem ID 175805
CAS Number 84057-95-4
CHEBI ID 8890
TTD ID D09RHQ

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM049  Increased risk of atrioventricular block
BM051  Increased risk of bradycardia
BM071  Increased risk of methemoglobinemia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ropivacaine
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  82
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[4], [5], [10]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[23]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[24]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[25]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[26]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[27]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[28]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Moderate    Inter Info   
[29]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[30]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0960
 
Lumefantrine
 
C30H32Cl3NO
 
6437380 
Moderate    Inter Info   
[4], [5], [32]
D1160
 
Obeticholic acid
 
C26H44O4
 
447715 
Moderate    Inter Info   
[33]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[35]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[34]
D1553
 
Terbinafine
 
C21H25N
 
1549008 
Moderate    Inter Info   
[39], [40], [41], [42]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[45]
D0367
 
Clotrimazole
 
C22H17ClN2
 
2812 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Minor    Inter Info   
[46], [47], [48]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Minor    Inter Info   
[49]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Minor    Inter Info   
[13], [15], [18]
D0416
 
Danazol
 
C22H27NO2
 
28417 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Minor    Inter Info   
[13], [15], [18]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Minor    Inter Info   
[13], [15], [18]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Minor    Inter Info   
[13], [14], [15], [16], [17], [12], [18]
   CYP450 enzyme induction Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[4], [5], [21], [22]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[31]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[4], [5], [34]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[36]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[4], [5], [37]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[4], [5], [38], [37]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[4], [5], [43]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[4], [5], [37]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Minor    Inter Info   
[52]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Minor    Inter Info   
[52]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Minor    Inter Info   
[52]
   Competitive inhibition of metabolic enzyme Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0231
 
Caffeine
 
C8H10N4O2
 
2519 
Minor    Inter Info   
[12]
D1427
 
Ropinirole
 
C16H24N2O
 
5095 
Minor    Inter Info   
[12]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Minor    Inter Info   
[5], [6], [50], [51], [9]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Minor    Inter Info   
[12]
D0994
 
Melatonin
 
C13H16N2O2
 
896 
Minor    Inter Info   
[12]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Minor    Inter Info   
[5], [12]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Minor    Inter Info   
[12]
D1405
 
Riluzole
 
C8H5F3N2OS
 
5070 
Minor    Inter Info   
[12]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Minor    Inter Info   
[12]
D1570
 
Theophylline
 
C7H8N4O2
 
2153 
Minor    Inter Info   
[5], [12]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[4], [5], [20]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[4], [5], [20]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[4], [5], [20]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[4], [5], [20]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[4], [5], [20]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[4], [5], [20]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[4], [5], [20]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Moderate    Inter Info   
[4], [5], [20]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[4], [5], [20]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[4], [5], [20]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[4], [5], [20]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[4], [5], [20]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[4], [5], [20]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[4], [5], [20]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[4], [5], [20]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[4], [5], [20]
   Additive hypotensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1752
 
Bupivacaine (liposome)
 
C18H28N2O
 
2474 
Major    Inter Info   
[1], [2]
   Increased risk of bradycardia Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[11], [12]
D0927
 
Lidocaine
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[12]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[11], [12]
D0110
 
Articaine
 
C13H20N2O3S
 
32170 
Moderate    Inter Info   
[12]
D0200
 
Bretylium
 
C11H17BrN+
 
2431 
Moderate    Inter Info   
[11], [12]
D0218
 
Bupivacaine
 
C18H28N2O
 
2474 
Moderate    Inter Info   
[12]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Moderate    Inter Info   
[11], [12]
D0916
 
Levobupivacaine
 
C18H28N2O
 
92253 
Moderate    Inter Info   
[12]
D1004
 
Mepivacaine
 
C15H22N2O
 
4062 
Moderate    Inter Info   
[12]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[11], [12]
   Increased risk of methemoglobinemia Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1337
 
Prilocaine
 
C13H20N2O
 
4906 
Major    Inter Info   
[3], [4], [5], [6], [7], [8], [9]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[5], [6], [19]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[5], [6], [19]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[5], [6], [19]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[5], [6], [19]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[5], [6], [19]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[5], [6], [19]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[5], [6], [19]
D1870
 
Proparacaine (ophthalmic)
 
C16H26N2O3
 
4935 
Moderate    Inter Info   
[5], [6], [19]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[5], [6], [19]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[5], [6], [19]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1909
 
Tilmanocept
 
NA
 
NA
Moderate    Inter Info   
[44]
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