Details of Drug

Drug General Information (ID: D1409)
Drug Name	Ripretinib
Drug Type	Small molecule
Drug Synonymous	1442472-39-0; Ripretinib [USAN]; UNII-9XW757O13D; GTPL9175; SCHEMBL14999718; 9XW757O13D; HY-112306; CS-0044835; N-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-N'-phenylurea; 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea; Urea, N-(4-bromo-5-(1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl)-2-fluorophenyl)-N'-phenyl- Click to Show/Hide
Disease Class	2A00: Brain cancer; 2A00-2F9Z: Solid tumour/cancer; 2A21: Mastocytosis; 2B5B: Gastrointestinal stromal tumour
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C24H21BrFN5O2
InChI	1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)
InChIKey	CEFJVGZHQAGLHS-UHFFFAOYSA-N
Canonical SMILES	CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
External Link
	Pubchem ID	71584930
	CAS Number	1442472-39-0
	TTD ID	D09AAK

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Ripretinib
Affected cellular transport
	Transporter inhibition					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[1], [2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[1], [2]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[1], [2]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1], [2]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[1], [2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[1], [2]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[1], [2]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1], [2]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[1], [2]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1], [2]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[1], [2]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1], [2]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [2]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[1], [2]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[1], [2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[1], [2]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[1], [2]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[1], [2]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1], [2]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[1], [2]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[1], [2]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[1], [2]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [2]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[1], [2]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[1], [2]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1], [2]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[1], [2]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1], [2]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[1], [2]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [2]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1], [2]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [2]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[1], [2]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[28]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[1], [2]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[1], [2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1], [2]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[1], [2]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [2]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [2]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [2]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1], [2]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[1], [2]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[1], [2]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[1], [2]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 89
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[5]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1], [2]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [2]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1], [2]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1], [2]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1], [2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1], [2]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1], [2]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1], [2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1], [2]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1], [3], [2]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1], [2]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1], [2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [2]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1], [2]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1], [2]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1], [2]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1], [2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [2]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [2]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1], [2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1], [2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1], [3], [2]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[1], [2]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1], [2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1], [2]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1], [2]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1], [2]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[1], [2]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1], [2]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[1], [2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [2]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1], [2]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1], [2]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1], [2]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1], [2]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[6], [7]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1], [3], [2]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1], [2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1], [2]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[1], [2]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[1], [2]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[8], [9], [1], [10], [11], [12], [13], [14]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[8], [9], [1]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[1], [2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [2]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [2]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[24], [25], [26], [27], [23]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1], [2]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1], [2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1], [2]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[29], [30], [31], [32], [33], [21], [23]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [2]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[34]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [2]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1], [2]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[35]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[1], [2]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1], [2]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1], [2]
	CYP450 enzyme induction					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [4], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [4], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[2]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1], [2]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1], [2]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [2]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1], [2]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [2]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1], [2]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [2]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1], [2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1], [2]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1], [2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1], [2]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1], [2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1], [2]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1], [2]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1], [2]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1], [3], [2]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[1], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1], [2]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1], [3], [2]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1], [2]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1], [2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1], [2]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1], [2]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1], [2]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1], [2]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [2]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[1], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [3], [2]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [2]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1], [2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [3], [2]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [2]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [2]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1], [2]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [3], [2]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [2]

References
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