Details of Drug

Drug General Information (ID: D1387)
Drug Name	Regorafenib
Drug Type	Small molecule
Drug Synonymous	Regorafenib; 755037-03-7; BAY 73-4506; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY73-4506; Regorafenib (BAY 73-4506); UNII-24T2A1DOYB; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY-73-4506; 24T2A1DOYB; CHEMBL1946170; CHEBI:68647; Stivarga (TN); BAY73-4506 hydrochloride; Regorafenib [USAN:INN] Click to Show/Hide
Disease Class	2B91: Colorectal cancer
Therapeutic Class	Vegf/Vegfr Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C21H15ClF4N4O3
InChI	1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey	FNHKPVJBJVTLMP-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
External Link
	Pubchem ID	11167602
	CAS Number	755037-03-7
	CHEBI ID	68647
	TTD ID	D09GDD
	INTEDE ID	DR1401
	VARIDT ID	DR00136

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Regorafenib
Affected cellular transport
	Transporter inhibition					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[18]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[15], [20]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[15], [1], [24]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[115]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[119]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[124]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[125]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[126]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[132]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[21]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[15], [26], [3]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[15], [26], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[15], [26], [3]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[15], [26], [3]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[15], [26], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[15], [26], [3]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[15], [26], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[15], [26], [3]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[15], [26], [3]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[9], [15], [1], [92], [93], [94], [95]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[15], [1], [92]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[15], [26], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[15], [26], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[15], [26], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[15], [26], [3]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[15], [26], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[15], [26], [3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[101]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[15], [1], [103]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[15], [26], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[15], [26], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[106]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[107]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[15], [1], [109]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[110], [111], [112]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[121], [112]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[15], [26], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[15], [26], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[15], [26], [3]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[15], [26], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[15], [26], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[15], [26], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[15], [26], [3]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[131]
	UGT inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[22], [23]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[38]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[96]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[3]
D0418		Dapagliflozin	C21H25ClO6	9887712	Minor		Inter Info	[130]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[3]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[3]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[3]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[3]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [105]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[113]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[114], [3]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[15], [1], [122]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[15], [1], [123], [122]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[114], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[3]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[15], [1], [122]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 114
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1], [4], [3]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1], [2], [3]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2], [3]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2], [3]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [2], [3]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2], [3]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[5]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[6], [7]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [2], [3]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2], [3]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1], [4], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2], [3]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[8]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1], [2], [3]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2], [3]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2], [3]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [4], [3]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2], [3]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1], [2], [3]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2], [3]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2], [3]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [4], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2], [3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2], [3]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2], [3]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2], [3]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[6], [14]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2], [3]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[15], [1], [16]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1], [2], [3]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2], [3]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2], [3]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2], [3]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[17]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1], [2], [3]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1], [4], [3]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2], [3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2], [3]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2], [3]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2], [3]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2], [3]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2], [3]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1], [2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [6], [19]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1], [2], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1], [2], [3]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[1], [2], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1], [2], [3]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2], [3]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2], [3]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1], [2], [3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1], [2], [3]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2], [3]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1], [2], [3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1], [2], [3]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2], [3]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[25]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2], [3]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2], [3]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[1], [4], [3]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1], [4], [3]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1], [2], [3]
D1669		Urokinase	NA	NA	Major		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[42], [43], [44]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[6], [84]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[42], [43], [44]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[42], [43], [44]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[42], [43], [44]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[87]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[42], [43], [44]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[42], [43], [44]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[6], [100]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[42], [43], [44]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[46], [47], [48], [49], [15], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[9], [10], [11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[12]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[13]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[9], [10], [11]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[27], [28], [29], [15], [1], [30], [31], [32], [33], [34], [35], [36], [37]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[27], [28], [29], [15], [1], [30], [31], [32], [33], [34], [35], [36], [37]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[45]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[85], [86]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[88], [89], [90], [91]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[88], [89], [90], [91]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[15], [97], [1], [98], [3]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[99]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[27], [28], [29], [15], [1], [30], [31], [32], [33], [34], [35], [36], [37]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[102]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[27], [28], [29], [15], [1], [30], [31], [32], [33], [34], [35], [36], [37]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [104]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[108]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[88], [89], [90], [91]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[15], [1], [116], [117], [118]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[127], [128]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [129]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[120]

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120	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
121	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
122	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
123	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
124	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
125	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
126	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
127	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
128	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
129	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
130	Product Information. Farxiga (dapagliflozin). Bristol-Myers Squibb, Princeton, NJ.
131	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
132	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.

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