Details of Drug

Drug General Information (ID: D1375)
Drug Name		Radium Ra 223 dichloride
Drug Type		Small molecule
Drug Synonymous		DB08913; Radium chloride Ra-223; Radium Ra 223 dichloride; Radium Ra-223 dichloride; Radium-223 chloride; Radium-223 dichloride Click to Show/Hide
Therapeutic Class		Diagnostic Radiopharmaceuticals

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Radium Ra 223 dichloride
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 157
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[6]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[6]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[6]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[6]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[6]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[6]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[6]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[6]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[6]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[6]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[6]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[6]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[6]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[6]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[6]
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[6]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[6]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[6]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[6]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[6]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[6]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[6]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[6]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[6]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[6]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[6]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[6]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[6]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[6]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[6]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[6]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[6]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[6]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[6]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[6]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[6]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[6]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[6]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[6]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[6]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[6]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[6]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[6]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[6]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[6]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[6]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[6]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[6]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[6]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[6]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[6]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[6]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[6]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[6]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[6]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[6]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[6]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[6]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[6]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[6]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[6]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[6]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[6]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[6]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[6]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[6]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[6]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[6]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[6]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[6]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[6]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[6]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[6]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[6]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[6]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[6]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[6]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[6]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[6]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[6]
D1168		Olaratumab	NA	NA	Moderate		Inter Info	[6]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[6]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[6]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[6]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[6]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[6]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[6]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[6]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[6]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[6]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[6]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[6]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[6]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[6]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[6]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[6]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[6]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[6]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[6]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[6]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[6]
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[6]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[6]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[6]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[6]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[6]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[6]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[6]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[6]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[6]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[6]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[6]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[6]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[6]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[6]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[6]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[6]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[6]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[6]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[6]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[6]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[6]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[6]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[6]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[6]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[6]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[6]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[1], [2], [8]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[6]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[6]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[6]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[6]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[6]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[6]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[6]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[6]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[6]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[6]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[6]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[6]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[6]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[6]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[6]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[6]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[6]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[6]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[6]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[6]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[6]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[6]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[6]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[6]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[6]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[6]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[6]
	Additive myelosuppressive effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2], [4], [5]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[1], [2], [7]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[1], [2], [7]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Bayer HealthCare Pharmaceuticals, Inc "Important Drug Warning: Xofigo."
4	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
5	Canadian Pharmacists Association "e-CPS."
6	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
7	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
8	Multum Information Services, Inc. Expert Review Panel.

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