Details of Drug

Drug General Information (ID: D1359)
Drug Name	Propylthiouracil
Drug Type	Small molecule
Drug Synonymous	propylthiouracil; 51-52-5; 6-Propyl-2-thiouracil; Propacil; Prothyran; Prothiurone; Procasil; Propycil; Thiuragyl; Protiural; Prothiucil; Prothycil; Propyl-Thiorist; Propyl-Thyracil; 2-Mercapto-6-propylpyrimidin-4-ol; 6-N-Propylthiouracil; Propythiouracil; Propilthiouracil; Propyl-Thiorit; Propylthiorit; 6-Propylthiouracil; Propylthiouracile; Thyreostat II; 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; Propiltiouracilo; 6-N-Propyl-2-thiouracil; 6-Thio-4-propyluracil; PTU (thyreostatic); Propylthiouracilum; 4-Propyl-2-thiouracil; Procasil; Propiltiouracile; PROPYL THIOURACIL; Propiltiouracile [DCIT]; Thyreos tat ii; HC210060; Propiltiouracilo [INN-Spanish]; Propylthiouracil (TN); Propylthiouracile [INN-French]; Propylthiouracilum [INN-Latin]; Ptu(thyreostatic); T0517-6237; Thyreostat propyl-thyracil; Propylthiouracil [INN:BAN:JAN]; Propylthiouracil (JP15/USP/INN); 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; 2-Mercapto-4-hydroxy-6-n-propylpyrimidine; 2-Mercapto-6-propyl-4-pyrimidone; 2-Mercapto-6-propylpyrimid-4-one; 2-Thio-4-oxo-6-propyl-1,3-pyrimidine; 2-Thio-6-propyl-1,3-pyrimidin-4-one; 4-Hydroxy-2-mercapto-6-propylpyrimidine; 6 Propyl 2 Thiouracil; 6-(n-Propyl)-2-thiouracil; 6-Prop yl-2-thiouracil; 6-Propil-tiouracile; 6-Propil-tiouracile [Italian]; 6-Propyl-2-thio-2,4(1H,3H)-pyrimidinedione; 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione; 6-n-PROPYL-2-MERCAPTO-4-HYDROXYPYRIMIDINE; 6-propyl-2 thiouracil; 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one; 6-propyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one; 6-propyl-2-thiopyrimidine-2,4(1H,3H)-dione; Propyl thiouracile Click to Show/Hide
Disease Class	5A02: Thyrotoxicosis
Therapeutic Class	Antithyroid Agents
Structure
Structure	3D Structure		2D Structure
Formula	C7H10N2OS
InChI	1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
InChIKey	KNAHARQHSZJURB-UHFFFAOYSA-N
Canonical SMILES	CCCC1=CC(=O)NC(=S)N1
External Link
	Pubchem ID	657298
	CAS Number	51-52-5
	CHEBI ID	8502
	TTD ID	D00MIN

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM032 Decreased renal excretion (Unspecific) BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Propylthiouracil
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[40], [41], [42]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[22], [23], [24]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[22], [23], [24]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[1], [2], [3]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[4], [5], [6]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[7]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[8]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[9]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[4], [5], [6]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[10], [11], [12], [1], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [13], [25]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[26], [27], [28], [29]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[26], [27], [28], [29]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[10], [11], [12], [1], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[10], [11], [12], [1], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[33]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[34]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[10], [11], [12], [1], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[13], [35]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[36]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[37], [38]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[39]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[13], [43]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[44]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[26], [27], [28], [29]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [13], [45], [46], [47]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[13], [48]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[49], [50]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[30], [31], [32]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[30], [31], [32]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
3	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
4	Canadian Pharmacists Association.
5	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
6	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
7	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
8	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
9	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
10	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
11	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
12	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
13	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
15	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
16	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
17	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
18	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
19	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
20	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
21	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
22	Product Information. Tapazole (methimazole). King Pharmaceuticals Inc, Bristol, TN.
23	Product Information. Propylthiouracil (propylthiouracil). Lederle Laboratories, Wayne, NJ.
24	Doherty JE, Perkins WH "Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease." Ann Intern Med 64 (1966): 489-507
25	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
26	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
27	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
28	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
29	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
30	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
31	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
32	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
33	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
34	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
35	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
36	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
37	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
38	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
39	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
40	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
41	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
42	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
43	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
44	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
45	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
46	Gilead Sciences, Inc "About Remdesivir.".
47	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
48	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
49	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
50	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

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