Details of Drug

Drug General Information (ID: D1241)
Drug Name	Pemetrexed
Drug Type	Small molecule
Drug Synonymous	Alimta; LYA; LY 231514; LY231514; Alimta (TN); LY 231,514; LY-2315; LY-231514; Pemetrexed (INN); Pemetrexed [INN:BAN]; LY-231,514; N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid; N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-d-glutamic acid; (2R)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid; 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID Click to Show/Hide
Disease Class	2C26: Pleural mesothelioma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C20H21N5O6
InChI	1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
InChIKey	WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
Canonical SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
External Link
	Pubchem ID	135410875
	CAS Number	137281-23-3
	CHEBI ID	63616
	TTD ID	D0Y4GO
	VARIDT ID	DR00318

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM026 Increased metabolism (Unspecific) BM027 Decreased renal excretion due to nephrotoxicity BM028 Competitive inhibition of renal tubular secretion BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Pemetrexed
Affected intra/extra-hepatic metabolism
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1802		Glucarpidase	Zn4+8	21195079	Moderate		Inter Info	[7], [80]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 68
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[51]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[51]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[51]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[51]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[55], [56], [57]
D0335		Cidofovir	C8H14N3O6P	60613	Moderate		Inter Info	[51]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[51]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[51]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[55], [56], [57]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[55], [56], [57]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[51]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[55], [56], [57]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[55], [56], [57]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[51]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[51]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[55], [56], [57]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[51]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[55], [56], [57]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[51]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[51]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[51]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[51]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[51]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[55], [56], [57]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[55], [56], [57]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[51]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[51]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[55], [56], [57]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[51]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[55], [56], [57]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[55], [56], [57]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[51]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[51]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[51]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[51]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[51]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[51]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[55], [56], [57]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[51]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[55], [56], [57]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[55], [56], [57]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[55], [56], [57]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[51]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[51]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[55], [56], [57]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[51]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[51]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[51]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[55], [56], [57]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[51]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[55], [56], [57]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[55], [56], [57]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[51]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[51]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[55], [56], [57]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[55], [56], [57]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[51]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[51]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[51]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[51]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[51]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[51]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[51]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[55], [56], [57]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[55], [56], [57]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[55], [56], [57]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[55], [56], [57]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[51]
	Competitive inhibition of renal tubular secretion					Drug Num: 74
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[51]
D0065		Aminosalicylic acid	C7H7NO3	4649	Moderate		Inter Info	[51]
D0079		Ampicillin	C16H19N3O4S	6249	Moderate		Inter Info	[51]
D0140		Aztreonam	C13H17N5O8S2	5742832	Moderate		Inter Info	[51]
D0257		Carbenicillin	C17H18N2O6S	20824	Moderate		Inter Info	[51]
D0273		Cefalotin	C16H16N2O6S2	6024	Moderate		Inter Info	[51]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[51]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[51]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[51]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[51]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[51]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[51]
D1768		Creatine	C4H9N3O2	586	Moderate		Inter Info	[51]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[51]
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[60]
D0596		Ertapenem	C22H25N3O7S	150610	Moderate		Inter Info	[51]
D0635		Famciclovir	C14H19N5O4	3324	Moderate		Inter Info	[51]
D0949		Loracarbef	C16H16ClN3O4	5284585	Moderate		Inter Info	[51]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[51]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[51]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[51]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[51]
D1851		Oseltamivir	C16H28N2O4	65028	Moderate		Inter Info	[51]
D0022		Acyclovir	C8H11N5O3	135398513	Moderate		Inter Info	[51]
D0073		Amoxicillin	C16H19N3O5S	33613	Moderate		Inter Info	[51]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[51]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Moderate		Inter Info	[51]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Moderate		Inter Info	[51]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[51]
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[51]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[51]
D0275		Cefapirin	C17H17N3O6S2	30699	Moderate		Inter Info	[51]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[51]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[51]
D0283		Cefonicid	C18H18N6O8S3	43594	Moderate		Inter Info	[51]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[51]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[51]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[51]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[51]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[51]
D0294		Ceftizoxime	C13H13N5O5S2	6533629	Moderate		Inter Info	[51]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[51]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[51]
D0369		Cloxacillin	C19H18ClN3O5S	6098	Moderate		Inter Info	[51]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[51]
D0519		Doripenem	C15H24N4O6S2	73303	Moderate		Inter Info	[51]
D0544		Dyphylline	C10H14N4O4	3182	Moderate		Inter Info	[51]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[51]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[51]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[51]
D0794		Imipenem	C12H17N3O4S	104838	Moderate		Inter Info	[51]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[51]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[51]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[51]
D1044		Meticillin	C17H20N2O6S	6087	Moderate		Inter Info	[51]
D1055		Mezlocillin	C21H25N5O8S2	656511	Moderate		Inter Info	[51]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[51]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[51]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[51]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[51]
D1192		Oxacillin	C19H19N3O5S	6196	Moderate		Inter Info	[51]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[51]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[51]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[51]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[51]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[51]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[51]
D1580		Ticarcillin	C15H16N2O6S2	36921	Moderate		Inter Info	[51]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[51]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Moderate		Inter Info	[51]
D1296		Piperacillin	C23H27N5O7S	43672	Moderate		Inter Info	[51]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[51]
D1672		Valaciclovir	C13H20N6O4	135398742	Moderate		Inter Info	[51]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[51]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [8]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[11]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[15], [7], [16]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[19]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[20], [21]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [22]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[20], [21]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[44]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[45]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[7], [46], [47]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[25], [48], [49]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[52], [53], [54]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[7], [46], [47]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[7], [46], [47]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [58]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [58]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[59]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[7], [46], [47]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[7], [46], [47]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[7], [46], [47]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[7], [46], [47]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[7], [46], [47]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[7], [46], [47]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[7], [46], [47]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[65]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[15], [7]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[7], [46], [47]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[7], [46], [47]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[52], [53], [54]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[7], [46], [47]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[7], [46], [47]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[7], [46], [47]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[7], [46], [47]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[7], [46], [47]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[7], [46], [47]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[76]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[77]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[77]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[7], [46], [47]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[7], [46], [47]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[7], [46], [47]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[7], [46], [47]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[7], [46], [47]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[7], [46], [47]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[7], [46], [47]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[7], [46], [47]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[7], [46], [47]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[7], [46], [47]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[77]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[7], [46], [47]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[82]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[83]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [84]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[85]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[93]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[52], [53], [54]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [94]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[7], [46], [47]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[95]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[15], [7], [96]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[7], [46], [47]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[97]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[98]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[7], [46], [47]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[7], [46], [47]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[7], [46], [47]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [9], [10]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[15], [17], [18]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[23]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[50]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[15], [7], [78], [79]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[15], [7], [78], [79]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[81]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[12], [13], [14]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[12], [13], [14]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[25], [15], [26]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[27]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[12], [13], [14]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[12], [13], [14]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[12], [13], [14]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[64]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [68], [69]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[25], [68], [69]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[86], [25], [15], [87], [88], [89], [68], [90], [91], [92], [69]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [68], [69]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[25], [68], [69]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[25], [68], [69]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[70], [71], [72]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[70], [71], [72]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[73], [74], [75]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[73], [74], [75]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[73], [74], [75]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[66], [67]
D1884		Sapropterin	C9H15N5O3	135398654	Moderate		Inter Info	[15], [99]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[61], [62], [63]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
5	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
6	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
9	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
10	Canadian Pharmacists Association "e-CPS."
11	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
12	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
13	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
14	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
15	Cerner Multum, Inc. "Australian Product Information.".
16	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
17	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
18	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
19	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
20	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
21	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
22	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
23	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
24	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
25	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
26	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
27	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
28	Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
29	Bennett CL, Schumock GT, Desai AA, et al "Thalidomide-associated deep vein thrombosis and pulmonary embolism." Am J Med 113 (2002): 603-6. [PMID: 12459408]
30	Cavo M, Zamagni E, Cellini C, et al. "Deep-vein thrombosis in patients with multiple myeloma receiving first-line thalidomide-dexamethasone therapy." Blood 100 (2002): 2272-3. [PMID: 12229885]
31	Escudier B, Lassau N, Leborgne S, Angevin E, Laplanche A "Thalidomide and venous thrombosis." Ann Intern Med 136 (2002): 711. [PMID: 11992318]
32	Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
33	Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
34	Lee CK, Barlogie B, Munshi N, et al "DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma." J Clin Oncol 21 (2003): 2732-9. [PMID: 12860952]
35	Osman K, Comenzo R, Rajkumar SV "Deep venous thrombosis and thalidomide therapy for multiple myeloma." N Engl J Med 344 (2001): 1951-2. [PMID: 11419443]
36	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
37	Rajkumar SV, Hayman S, Gertz MA, et al. "Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma." J Clin Oncol 20 (2002): 4319-23. [PMID: 12409330]
38	Urbauer E, Kaufmann H, Nosslinger T, Raderer M, Drach J "Thromboembolic events during treatment with thalidomide." Blood 99 (2002): 4247-8. [PMID: 12043695]
39	Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R "Thalidomide alone or with dexamethasone for previously untreated multiple myeloma." J Clin Oncol 21 (2003): 16-9. [PMID: 12506164]
40	Zangari M, Anaissie E, Barlogie B, et al "Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy." Blood 98 (2001): 1614-5. [PMID: 11520815]
41	Zangari M, Barlogie B, Anaissie E, et al "Deep vein thrombosis in patients with mutiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation." Br J Haematol 126 (2004): 715-21. [PMID: 15327525]
42	Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
43	Desai AA, Vogelzang NJ, Rini BI, Ansari R, Krauss S, Stadler WM "A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma." Cancer 95 (2002): 1629-36. [PMID: 12365009]
44	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
45	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
46	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
47	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
48	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
49	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
50	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
51	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
52	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
53	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
54	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
55	Tietjen DP "Recurrence and specificity of nephrotic syndrome due to tolmetin." Am J Med 87 (1989): 354-5
56	Shand DG, Epstein C, Kinberg-Calhoun J, et al "The effect of etodolac administration on renal function in patients with arthritis." J Clin Pharmacol 26 (1986): 269-74
57	Turner GA, Walker RJ, Bailey RR, et al "Sulindac-induced acute interstitial nephritis." N Z Med J 97 (1984): 239-40
58	Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]
59	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
60	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
61	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
62	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
63	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
64	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
65	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
66	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
67	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
68	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
69	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
70	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
71	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
72	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
73	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
74	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
75	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
76	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
77	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
78	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
79	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
80	Product Information. Voraxaze (glucarpidase). BTG International Inc, West Conshohocken, PA.
81	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
82	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
83	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
84	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
85	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
86	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
87	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
88	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
89	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
90	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
91	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
92	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
93	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
94	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
95	AnazaoHealth Corporation "P32 Sodium Phosphate."
96	Multum Information Services, Inc. Expert Review Panel.
97	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
98	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
99	Product Information. Kuvan (sapropterin). BioMarin Pharmaceutical Inc, Novato, CA.

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