Details of Drug

Drug General Information (ID: D1188)
Drug Name	Orphenadrine
Drug Type	Small molecule
Drug Synonymous	Antiflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Lysantin; Mefenamine; Mephenamine; Methyldiphenylhydramine; Myolin; Myotrol; ORP; Orfenadrina; Orfro; Orphenadine; Orphenadinum; Orphenadrin; Orphenadrinum; Orphenate; Orphenedrine; Norflex Orphenadrine Citrate; Sodium Mefenamine; WS 2434; Banflex (TN); Biorphen (TN); Brocasipal (TN); Disipal (TN); Flexon (TN); Mephenamin (TN); Mialgin (TN); Norflex (TN); O-Methyldiphenhydramine; O-Monomethyldiphenhydramine; Orfenadrina [INN-Spanish]; Orphenadrine(INN); Orphenadrine [INN:BAN]; Orphenadrinum [INN-Latin]; Beta-Dimethylaminoethyl 2-methylbenzhydryl ether; Phenyl-o-tolylmethyl dimethyaminoethyl ether; Beta-Dimethylaminoethyl-2-methylbenzhydryl ether; N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin; N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine; N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine; N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine; N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine; N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine; N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine; 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine; 2-Methyldiphenhydramine Click to Show/Hide
Disease Class	8A00: Parkinsonism
Therapeutic Class	Antiparkinson Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H23NO
InChI	1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3
InChIKey	QVYRGXJJSLMXQH-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
External Link
	Pubchem ID	4601
	CAS Number	83-98-7
	CHEBI ID	7789
	TTD ID	D0D9FV
	VARIDT ID	DR00835

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM033 Additive anticholinergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM054 Increased risk of GI mucosal injury/bleeding risk BM061 Increased risk of hyperpyrexia BM091 Antagonize the effect of cholinergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Orphenadrine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[67], [68], [36], [69], [70], [71], [72], [73], [74], [75], [76], [77]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 83
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[43], [44]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[50], [52], [58]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[50], [52], [58]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[50], [52], [58]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[90], [91], [92]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[93], [90], [94], [91], [92], [95], [96], [97]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[93], [90], [94], [91], [92], [95], [96], [97]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[50], [52], [58]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[50], [52], [58]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[93], [90], [94], [91], [92], [95], [96], [97]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[93], [90], [94], [91], [92], [95], [96], [97]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[93], [90], [94], [91], [92], [95], [96], [97]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[87], [111], [89]
	Additive antimotility effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[98]
	Additive CNS depression effects					Drug Num: 148
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [1], [10], [11], [12], [13], [14], [15], [16]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[1]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[17]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[17]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[17]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[17]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[30], [31]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[32]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[33]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[40], [41], [42]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[60], [61]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[62], [36], [63]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[40], [41], [42]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[40], [41], [42]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[62], [36], [63]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[62], [36], [63]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[40], [41], [42]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[40], [41], [42]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[40], [41], [42]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[40], [41], [42]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[40], [41], [42]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[40], [41], [42]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[40], [41], [42]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[40], [41], [42]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[40], [41], [42]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[40], [41], [42]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[40], [41], [42]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[40], [41], [42]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[40], [41], [42]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[40], [41], [42]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[40], [41], [42]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[40], [41], [42]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[40], [41], [42]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[86], [87], [88], [36], [89]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[40], [41], [42]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[40], [41], [42]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[40], [41], [42]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[40], [41], [42]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[40], [41], [42]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[40], [41], [42]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[40], [41], [42]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[40], [41], [42]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[40], [41], [42]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[40], [41], [42]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[40], [41], [42]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[40], [41], [42]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[40], [41], [42]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[40], [41], [42]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[40], [41], [42]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[40], [41], [42]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[40], [41], [42]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[40], [41], [42]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[99]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[40], [41], [42]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[40], [41], [42]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[40], [41], [42]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[40], [41], [42]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[40], [41], [42]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[40], [41], [42]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[40], [41], [42]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[40], [41], [42]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[40], [41], [42]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[40], [41], [42]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[40], [41], [42]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[68], [101]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[40], [41], [42]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[40], [41], [42]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[40], [41], [42]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[102]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[40], [41], [42]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[40], [41], [42]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[40], [41], [42]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[40], [41], [42]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[103]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[40], [41], [42]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[40], [41], [42]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[104], [105]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[40], [41], [42]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[40], [41], [42]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[40], [41], [42]
D1183		Opium	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[40], [41], [42]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[40], [41], [42]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[40], [41], [42]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[40], [41], [42]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[40], [41], [42]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[40], [41], [42]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[40], [41], [42]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[40], [41], [42]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[40], [41], [42]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[40], [41], [42]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[40], [41], [42]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[40], [41], [42]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[40], [41], [42]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[40], [41], [42]
D1675		Valerian	NA	NA	Moderate		Inter Info	[40], [41], [42]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[40], [41], [42]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[40], [41], [42]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[40], [41], [42]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[40], [41], [42]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[40], [41], [42]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[40], [41], [42]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[40], [41], [42]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[40], [41], [42]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[40], [41], [42]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[40], [41], [42]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[40], [41], [42]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[40], [41], [42]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[40], [41], [42]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[40], [41], [42]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[40], [41], [42]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[40], [41], [42]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[109]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[40], [41], [42]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[40], [41], [42]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[110]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[40], [41], [42]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[40], [41], [42]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[40], [41], [42]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[40], [41], [42]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[40], [41], [42]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[40], [41], [42]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[40], [41], [42]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[40], [41], [42]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[40], [41], [42]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[40], [41], [42]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[40], [41], [42]
	Additive hypertensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[106], [107], [108]
	Additive hypotensive effects					Drug Num: 62
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[37], [38], [39]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[37], [38], [39]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[37], [38], [39]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[37], [38], [39]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[37], [38], [39]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[37], [38], [39]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[37], [38], [39]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[37], [38], [39]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[37], [38], [39]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[37], [38], [39]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[37], [38], [39]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[37], [38], [39]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[37], [38], [39]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[37], [38], [39]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[37], [38], [39]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[37], [38], [39]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[37], [38], [39]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[37], [38], [39]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[37], [38], [39]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[37], [38], [39]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[37], [38], [39]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[37], [38], [39]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[37], [38], [39]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[37], [38], [39]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[37], [38], [39]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[37], [38], [39]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[37], [38], [39]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[37], [38], [39]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[37], [38], [39]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[37], [38], [39]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[37], [38], [39]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[37], [38], [39]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[37], [38], [39]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[37], [38], [39]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[37], [38], [39]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[37], [38], [39]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[37], [38], [39]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[37], [38], [39]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[37], [38], [39]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[37], [38], [39]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[37], [38], [39]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[37], [38], [39]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[37], [38], [39]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[37], [38], [39]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[37], [38], [39]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[37], [38], [39]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[37], [38], [39]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[37], [38], [39]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[37], [38], [39]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[37], [38], [39]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[37], [38], [39]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[37], [38], [39]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[37], [38], [39]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[37], [38], [39]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[37], [38], [39]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[37], [38], [39]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[37], [38], [39]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[37], [38], [39]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[37], [38], [39]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[37], [38], [39]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[37], [38], [39]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[37], [38], [39]
	Additive neuromuscular blocking effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[64], [65], [66]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[18], [19], [20], [21], [22], [23], [24], [25], [26], [28], [29]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[36], [100]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[78], [79]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[78], [79]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[80], [81], [82], [83], [84], [85]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[78], [79]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[80], [81], [82], [83], [84], [85]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[78], [79]
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[78], [79]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[80], [81], [82], [83], [84], [85]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[78], [79]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[78], [79]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[80], [81], [82], [83], [84], [85]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[80], [81], [82], [83], [84], [85]

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