Details of Drug

Details of Drug

 Drug General Information (ID: D1173)
  Drug Name
Olsalazine
  Drug Type Small molecule
  Drug Synonymous
Azodisal; Dipentum; Olsalazine sodium; Di-mesalazine
    Click to Show/Hide
  Disease Class DD71: Ulcerative colitis
  Therapeutic Class Immunosuppressive Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H10N2O6
  InChI 1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)
  InChIKey QQBDLJCYGRGAKP-UHFFFAOYSA-N
  Canonical SMILES C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)O
  External Link
Pubchem ID 22419
CAS Number 15722-48-2
CHEBI ID 7770
TTD ID D00KRE
INTEDE ID DR2394

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
BM018  Non-CYP450 enzyme inhibition
BM027  Decreased renal excretion due to nephrotoxicity
BM050  Increased risk of bleeding
BM064  Increased risk of hypoglycemia
BM072  Increased risk of nephrotoxicity
  Relation Graph
 Full list of drugs interacting with Olsalazine
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Moderate    Inter Info   
[124], [125], [126], [127], [128], [129], [130], [131]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Moderate    Inter Info   
[124], [125], [126], [127], [128], [129], [130], [131]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[155], [128], [129]
      Affected excretion pathways
   Decreased renal excretion due to nephrotoxicity Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[133]
D0668
 
Flucytosine
 
C4H4FN3O
 
3366 
Moderate    Inter Info   
[137]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[148], [14], [149], [150], [151]
D1543
 
Telbivudine
 
C10H14N2O5
 
159269 
Moderate    Inter Info   
[152]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[153]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[154]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Minor    Inter Info   
[156], [157], [158]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Minor    Inter Info   
[156], [157], [158]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Minor    Inter Info   
[156], [157], [158]
   Increased risk of hypoglycemia Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
   Increased risk of nephrotoxicity Drug Num:  80
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Major    Inter Info   
[1]
D0472
 
Diatrizoate
 
C11H9I3N2O4
 
2140 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0765
 
Human immunoglobulin G (intravenous)
 
NA
 
NA
Major    Inter Info   
[9], [10], [11]
D0832
 
Iodixanol
 
C35H44I6N6O15
 
3724 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Major    Inter Info   
[12], [13]
D0761
 
Human botulinum neurotoxin A/B immune globulin
 
NA
 
NA
Major    Inter Info   
[9], [10], [11]
D0763
 
Human cytomegalovirus immune globulin
 
NA
 
NA
Major    Inter Info   
[9], [10], [11]
D0768
 
Human Rho(D) immune globulin
 
NA
 
NA
Major    Inter Info   
[9], [10], [11]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Major    Inter Info   
[14], [15]
D0831
 
Iodipamide
 
C20H14I6N2O6
 
3739 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0836
 
Iopromide
 
C18H24I3N3O8
 
3736 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0837
 
Iothalamic acid
 
C11H9I3N2O4
 
3737 
Major    Inter Info   
[4], [5], [6]
D0838
 
Ioversol
 
C18H24I3N3O9
 
3741 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D0839
 
Ioxilan
 
C18H24I3N3O8
 
3743 
Major    Inter Info   
[2], [3], [4], [5], [6], [7], [8]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Major    Inter Info   
[16], [17], [18]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[16], [17], [18]
D0022
 
Acyclovir
 
C8H11N5O3
 
135398513 
Moderate    Inter Info   
[120], [121], [122], [123]
D0056
 
Amikacin
 
C22H43N5O13
 
37768 
Moderate    Inter Info   
[120], [121], [122], [123]
D0057
 
Amikacin (liposome)
 
C22H43N5O13
 
37768 
Moderate    Inter Info   
[121], [122], [123]
D0075
 
Amphotericin B
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[120], [121], [122], [123]
D0076
 
Amphotericin B (cholesteryl sulfate)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[121], [122], [123]
D0077
 
Amphotericin B (lipid complex)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[121], [122], [123]
D0078
 
Amphotericin B (liposomal)
 
C47H73NO17
 
5280965 
Moderate    Inter Info   
[121], [122], [123]
D0142
 
Bacitracin
 
C66H103N17O16S
 
10909430 
Moderate    Inter Info   
[120], [121], [122], [123]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Moderate    Inter Info   
[120], [121], [122], [123]
D0252
 
Capreomycin
 
C50H88N28O15
 
3000502 
Moderate    Inter Info   
[120], [121], [122], [123]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[120], [121], [122], [123]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[120], [121], [122], [123]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[132]
D0383
 
Colistimethate
 
C58H105N16O28S5-5
 
70789202 
Moderate    Inter Info   
[120], [121], [122], [123]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[120], [121], [122], [123]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[120], [121], [122], [123]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Moderate    Inter Info   
[120], [121], [122], [123]
D0623
 
Etidronic acid
 
C2H8O7P2
 
3305 
Moderate    Inter Info   
[134], [135], [136]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Moderate    Inter Info   
[120], [121], [122], [123]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Moderate    Inter Info   
[120], [121], [122], [123]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Moderate    Inter Info   
[120], [121], [122], [123]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Moderate    Inter Info   
[120], [121], [122], [123]
D0718
 
Gentamicin
 
C21H43N5O7
 
3467 
Moderate    Inter Info   
[120], [121], [122], [123]
D0783
 
Ibandronate
 
C9H23NO7P2
 
60852 
Moderate    Inter Info   
[138], [139], [140], [135], [141], [142], [143], [144], [145], [146], [136], [147]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Moderate    Inter Info   
[120], [121], [122], [123]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Moderate    Inter Info   
[120], [121], [122], [123]
D0876
 
Kanamycin
 
C18H36N4O11
 
6032 
Moderate    Inter Info   
[120], [121], [122], [123]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Moderate    Inter Info   
[120], [121], [122], [123]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Moderate    Inter Info   
[120], [121], [122], [123]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Moderate    Inter Info   
[121], [122], [123]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Moderate    Inter Info   
[120], [121], [122], [123]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[120], [121], [122], [123]
D1030
 
Methoxyflurane
 
C3H4Cl2F2O
 
4116 
Moderate    Inter Info   
[120], [121], [122], [123]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Moderate    Inter Info   
[120], [121], [122], [123]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Moderate    Inter Info   
[120], [121], [122], [123]
D1120
 
Neomycin
 
C23H46N6O13
 
8378 
Moderate    Inter Info   
[120], [121], [122], [123]
D1126
 
Netilmicin
 
C21H41N5O7
 
441306 
Moderate    Inter Info   
[120], [121], [122], [123]
D0709
 
Gallium nitrate
 
GaN3O9
 
61635 
Moderate    Inter Info   
[120], [121], [122], [123]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Moderate    Inter Info   
[120], [121], [122], [123]
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[121], [122], [123]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Moderate    Inter Info   
[121], [122], [123]
D0964
 
Lutetium Lu 177 dotatate
 
C65H87LuN14O19S2
 
76966897 
Moderate    Inter Info   
[120], [121], [122], [123]
D1091
 
Moxetumomab Pasudotox
 
NA
 
NA
Moderate    Inter Info   
[120], [121], [122], [123]
D1304
 
Plazomicin
 
C25H48N6O10
 
42613186 
Moderate    Inter Info   
[120], [121], [122], [123]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Moderate    Inter Info   
[120], [121], [122], [123]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Moderate    Inter Info   
[120], [121], [122], [123]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[120], [121], [122], [123]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Moderate    Inter Info   
[120], [121], [122], [123]
D1217
 
Pamidronic acid
 
C3H11NO7P2
 
4674 
Moderate    Inter Info   
[134], [135], [136]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Moderate    Inter Info   
[120], [121], [122], [123]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[120], [121], [122], [123]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Moderate    Inter Info   
[120], [121], [122], [123]
D1310
 
Polymyxin B
 
C56H98N16O13
 
49800004 
Moderate    Inter Info   
[120], [121], [122], [123]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Moderate    Inter Info   
[120], [121], [122], [123]
D1507
 
Streptomycin
 
C21H39N7O12
 
19649 
Moderate    Inter Info   
[120], [121], [122], [123]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Moderate    Inter Info   
[120], [121], [122], [123]
D1597
 
Tobramycin
 
C18H37N5O9
 
36294 
Moderate    Inter Info   
[120], [121], [122], [123]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Moderate    Inter Info   
[120], [121], [122], [123]
D1672
 
Valaciclovir
 
C13H20N6O4
 
135398742 
Moderate    Inter Info   
[121], [122], [123]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[120], [121], [122], [123]
D1680
 
Vancomycin
 
C66H75Cl2N9O24
 
14969 
Moderate    Inter Info   
[120], [121], [122], [123]
D1727
 
Zoledronic acid
 
C5H10N2O7P2
 
68740 
Moderate    Inter Info   
[138], [139], [140], [135], [141], [142], [143], [144], [145], [146], [136], [147]
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137 Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
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154 Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
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158 Product Information. Dipentum (olsalazine). Meda Pharmaceuticals, Somerset, NJ.