Details of Drug

Drug General Information (ID: D1167)
Drug Name	Olaparib
Drug Type	Small molecule
Drug Synonymous	AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one Click to Show/Hide
Disease Class	2C73: Ovarian cancer; 2C10: Pancreatic cancer; 2C82: Prostate cancer
Therapeutic Class	Poly (Adp-Ribose) Polymerase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C24H23FN4O3
InChI	1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChIKey	FDLYAMZZIXQODN-UHFFFAOYSA-N
Canonical SMILES	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
External Link
	Pubchem ID	23725625
	CAS Number	763113-22-0
	CHEBI ID	83766
	TTD ID	D0J9HW
	INTEDE ID	DR1188
	VARIDT ID	DR00221

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Olaparib
Affected cellular transport
	Transporter inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[8], [24], [25]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [26]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[7], [8]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [8]
D0412		Dalfampridine	C5H6N2	1727	Moderate		Inter Info	[7], [8], [41]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[7], [8]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[7], [8]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[7], [8]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[7], [8], [62]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[66]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[7], [8]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[7], [8]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[79], [24], [80]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[81]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[7], [82]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[86]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[87]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[7], [8]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7], [8]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[7], [8]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[7], [8]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 95
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7], [8], [9]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[7], [8], [9]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7], [8], [9]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7], [8], [9], [10]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [9], [10]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[7], [8], [9]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8], [9], [10]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7], [8], [9], [10]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7], [8], [9], [10]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[7], [8], [9]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[7], [8], [9]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[7], [8], [9]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7], [8], [9], [10]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[7], [8], [9]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[7], [8], [9]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[7], [8], [9]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[7], [8], [9]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7], [8], [9]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[7], [8], [9]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7], [8], [9], [10]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[7], [8], [9]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7], [8], [9], [10]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[7], [8], [9]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8], [9], [10]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7], [8], [9], [10]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7], [8], [9], [10]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7], [8], [9], [10]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7], [8], [9], [10]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[7], [8], [9]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[7], [8], [9]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[7], [8], [9]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[7], [8], [9]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[7], [8], [9]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[7], [8], [9]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7], [8], [9], [10]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7], [8], [9], [10]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7], [8], [9], [10]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7], [8], [9], [10]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [9], [10]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7], [8], [9], [10]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7], [8], [9], [10]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7], [8], [9], [10]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[7], [8]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[9]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[7], [8]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[9]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[9]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[7], [8]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[9]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[7], [8]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[7], [8]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[7], [8], [9]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[7], [8]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[9]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[9]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[7], [8]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[9]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[7], [8]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[9]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[7], [8], [9]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[9]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7], [8]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[7], [8], [9]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[7], [8], [9]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [8]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[7], [8], [53], [54]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[9]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[55], [7], [8]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[56]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[7], [8], [9]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[9]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [8], [9]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[68]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[9]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[9]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[69]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[8], [9]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[70]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[7], [8]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[7], [8]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[7], [8]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[9]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[9]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[7], [8], [9]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[7], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[7], [8]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[9]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[7], [8]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7], [8]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[9]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[7], [8]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[9]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [8]
	CYP450 enzyme induction					Drug Num: 93
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0106		Armodafinil	C15H15NO2S	9690109	Major		Inter Info	[7], [8], [9]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[7], [8], [9]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[7], [8], [9]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[7], [8], [9]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[7], [8], [9]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[7], [8], [9]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[7], [8], [9]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[7], [8], [9]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[7], [8], [9]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[7], [8], [9]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[7], [8], [9]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[7], [8], [9]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[7], [8], [9]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[7], [8], [9]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[7], [8], [9]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[7], [8], [9]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[7], [8], [9]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[7], [8], [9]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[7], [8], [9]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[7], [8], [9]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[7], [8], [9]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[7], [8], [9]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[7], [8], [9]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[7], [8], [9]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[7], [8], [37]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[7], [8], [9]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[7], [8], [9]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[7], [8], [37]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[7], [8], [37]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[7], [8], [37]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[7], [8], [9]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[7], [8], [9]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[7], [8], [37]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[7], [8], [37]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[7], [8], [9]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[7], [8], [9]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[8], [44]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[7], [8], [37]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[8], [46], [9]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[8], [44]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[7], [8], [9]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[7], [8], [37]
D0702		Frovatriptan	C14H17N3O	77992	Moderate		Inter Info	[7], [8], [37]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[7], [8], [9]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[7], [8], [37]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[7], [8], [37]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[7], [8], [37]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[8], [44]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[7], [8], [37]
D0994		Melatonin	C13H16N2O2	896	Moderate		Inter Info	[7], [8], [37]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[7], [8], [37]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[7], [8], [37]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[7], [8], [9]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[7], [8], [37]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[8], [46], [9]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[8], [46], [9]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[7], [8], [37]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[8], [46], [9]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[7], [67]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[7], [8], [9]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[7], [8], [9]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[7], [8], [9]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7], [8], [9]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[7], [8], [9]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[7], [8], [9]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[8], [85]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[7], [8], [37]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[7], [8], [37]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[7], [8], [9]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[7], [8], [9]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[7], [8], [9]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[7], [8], [37]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[7], [8], [37]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[7], [8], [37]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[7], [8], [37]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[7], [8], [37]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[7], [8], [37]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[7], [8], [9]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[7], [8], [9]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[7], [8], [37]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[7], [8], [9]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[7], [8], [37]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[7], [8], [9]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[7], [8], [37]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[7], [8], [37]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[7], [8], [37]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[7], [8], [37]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[7], [8], [37]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[7], [8], [9]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[7], [8], [9]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[7], [8], [37]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[7], [8], [37]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 172
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[8], [11]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[16]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[17], [18]
D1111		Natalizumab	NA	NA	Major		Inter Info	[19]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[7], [8], [23]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[7], [27]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[31]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[17], [18]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[33]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[8], [9]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[8], [9]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[28], [34], [35]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[8], [9]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[38], [39], [40]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[8], [9]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[8], [9]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[7], [8]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[8], [9]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[8], [9]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[8], [9]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[8], [9]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[8], [9]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[8], [9]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[8], [9]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[8], [9]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[8], [9]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[8], [9]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[38], [39], [40]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[8], [9]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[8], [9]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[8], [9]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[8], [9]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[8], [9]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[8], [9]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[8], [9]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[8], [9]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[8], [9]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[8], [9]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[8], [9]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[8], [9]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[8], [9]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[8], [9]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[8], [9]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[42]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[43]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[8], [9]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[8], [9]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[8], [9]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[45]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[8], [9]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[8], [9]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[8], [9]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[8], [9]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[8], [9]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[8], [9]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[8], [9]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[8], [9]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[8], [9]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[8], [9]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[8], [9]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[8], [9]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[8], [9]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[8], [9]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[8], [9]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[8], [9]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[8], [9]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[8], [9]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[8], [9]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[8], [9]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[8], [9]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[8], [9]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[8], [9]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[8], [9]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[8], [9]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[8], [9]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[8], [9]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[8], [9]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[8], [9]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[8], [9]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[8], [9]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[8], [9]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[8], [9]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[8], [9]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[8], [9]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[8], [9]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[8], [9]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[8], [9]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[8], [9]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[8], [9]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[8], [9]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[8], [9]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[8], [9]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[8], [9]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[8], [9]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[8], [9]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[8], [9]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[8], [9]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[43]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[8], [9]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[8], [9]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[8], [9]
D0939		Lisocabtagene maraleucel	NA	NA	Moderate		Inter Info	[8], [9]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[8], [9]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[8], [9]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[43]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[8], [9]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[8], [9]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[71]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[8], [9]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[8], [9]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[8], [9]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[8], [9]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[8], [9]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[83]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[7], [8], [84]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[8], [9]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[8], [9]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[8], [9]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[8], [9]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[8], [9]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[8], [9]
D1168		Olaratumab	NA	NA	Moderate		Inter Info	[8], [9]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[88]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[8], [9]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[8], [9]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[8], [9]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[89]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[8], [9]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[8], [9]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[8], [9]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[8], [9]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[8], [9]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[8], [9]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[8], [9]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[8], [9]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[8], [9]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[8], [9]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[92]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[8], [9]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[8], [93]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[8], [9]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[8], [9]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[8], [9]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[8], [9]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[8], [9]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[8], [9]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[8], [9]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[8], [9]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[8], [9]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[8], [9]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[8], [9]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[8], [9]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[8], [9]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[8], [9]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[8], [9]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[8], [9]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[8], [9]
D1639		Trifluridine	C10H11F3N2O5	6256	Moderate		Inter Info	[8], [9]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[8], [9]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[8], [9]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[94]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[8], [9]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[8], [9]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[8], [9]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[8], [9]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[8], [9]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[8], [12], [13]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[7], [14], [15]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[32]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[36]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[7], [8], [50], [51]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[7], [8], [50], [51]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[20], [21], [22]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[20], [21], [22]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[20], [21], [22]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[20], [21], [22]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[20], [21], [22]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[28], [7], [29]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[30]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[20], [21], [22]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[20], [21], [22]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[20], [21], [22]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[52]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[28], [57], [58]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[72], [28], [7], [73], [74], [75], [57], [76], [77], [78], [58]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[28], [57], [58]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[28], [57], [58]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[59], [60], [61]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[59], [60], [61]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[63], [64], [65]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[63], [64], [65]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[47], [48], [49]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[90], [91]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[47], [48], [49]

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