Details of Drug

Drug General Information (ID: D1160)
Drug Name	Obeticholic acid
Drug Type	Small molecule
Drug Synonymous	INT747; INT-747; 6-ethylchenodeoxycholic acid; 6-ECDCA; OCA; 6-Et CDCA Click to Show/Hide
Disease Class	DB96: Autoimmune liver disease; 7A00-7A0Z: Insomnia
Therapeutic Class	Gi Agents
Structure
Structure	3D Structure		2D Structure
Formula	C26H44O4
InChI	1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
InChIKey	ZXERDUOLZKYMJM-ZWECCWDJSA-N
Canonical SMILES	CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O
External Link
	Pubchem ID	447715
	CAS Number	459789-99-2
	CHEBI ID	43602
	TTD ID	D0M4WA
	INTEDE ID	DR1183

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM085 Antagonize the effect of antithrombotic agents
Relation Graph

Full list of drugs interacting with Obeticholic acid
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[13]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[13]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[13]
Affected cellular transport
	Transporter inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[1], [2], [3]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[24], [2], [25]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[29]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[12]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[13]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[14]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[13]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[13]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[13]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[13]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[17], [18], [19], [20]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[13]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[13]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[1], [21]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[13]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[13]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[13]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[22]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[23]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[13]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [26], [27]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[28]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[30], [31], [17], [32], [1], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[13]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[46], [47]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[13]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[1], [48]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[13]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[49]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[50], [1], [51]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[13]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1], [52], [53]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[54], [55]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[13]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[13]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[13]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[13]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[13]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[1], [56]
D0994		Melatonin	C13H16N2O2	896	Minor		Inter Info	[50]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[15], [16], [13]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[15], [16], [13]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[15], [16], [13]

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