Details of Drug

Drug General Information (ID: D1143)
Drug Name	Nitisinone
Drug Type	Small molecule
Drug Synonymous	Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione Click to Show/Hide
Disease Class	5C50: Metabolism inborn error
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C14H10F3NO5
InChI	1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChIKey	OUBCNLGXQFSTLU-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
External Link
	Pubchem ID	115355
	CAS Number	104206-65-7
	CHEBI ID	50378
	TTD ID	D0V1UW

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme
Relation Graph

Full list of drugs interacting with Nitisinone
Affected cellular transport
	Transporter inhibition					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[7]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[7]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[7]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[7]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[7]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[7]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[7]
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[38], [39], [7]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[7]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 131
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[1], [2]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[3], [1], [4]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[3], [1], [4]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3], [1], [4]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[3], [1], [7]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[3], [1], [4]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[3], [1], [4]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[3], [1], [4]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[3], [1], [4]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [1], [7]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[3], [1], [4]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[3], [1], [7]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[3], [1], [7]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[3], [1], [4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[8]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3], [1], [4]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [1], [7]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[3], [1], [4]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[3], [1], [4]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[3], [1], [4]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[9], [10]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[3], [1], [4]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[3], [1], [7]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[3], [1], [4]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [1], [4]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[3], [1], [4]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[11]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[3], [1], [4]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[3], [1], [7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[3], [1], [4]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[3], [1], [4]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [1], [7]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[3], [1], [4]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [1], [4]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[3], [1], [4]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[13]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[14]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[3], [1], [7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[3], [1], [4]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[3], [1], [4]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[3], [1], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[3], [1], [4]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[16], [17]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[3], [1], [4]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[3], [1], [7]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[3], [1], [7]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[3], [1], [7]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[3], [1], [4]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[3], [1], [4]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[19]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[3], [1], [4]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[3], [1], [4]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[3], [1], [4]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[3], [1], [7]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1], [4], [20], [21]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[9], [10]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[3], [1], [7]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[3], [1], [4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [1], [7]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[3], [1], [4]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[3], [1], [4]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[24]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[25]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[3], [1], [7]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [1], [4]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[3], [1], [4]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[3], [1], [7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[3], [1], [4]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[3], [1], [4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[3], [1], [4]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[26]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [1], [4]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[27]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[3], [1], [4]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[28]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[3], [1], [4]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[3], [1], [4]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[3], [1], [4]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[29]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[3], [1], [7]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[3], [1], [7]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[3], [1], [7]
D1056		Micafungin	C56H71N9O23S	477468	Moderate		Inter Info	[3], [1], [4]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [4], [30], [31]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[32], [33]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[3], [1], [7]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[3], [1], [7]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[3], [1], [4]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[3], [1], [4]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[34]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[3], [1], [4]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [1], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[3], [1], [4]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[3], [1], [4]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[3], [1], [4]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3], [1], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[3], [1], [7]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[4], [35], [36]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[3], [1], [7]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3], [1], [4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[3], [1], [7]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[3], [1], [7]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[3], [1], [4]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[3], [1], [4]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[3], [1], [4]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[3], [1], [4]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[3], [1], [4]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[3], [1], [4]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[3], [1], [7]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[3], [1], [7]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[3], [1], [4]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[3], [1], [7]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[3], [1], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[3], [1], [4]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[3], [1], [4]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [1], [7]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [1], [7]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[3], [1], [4]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[3], [1], [4]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[3], [1], [4]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3], [1], [7]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[41], [42]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[3], [1], [4]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [1], [7]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[3], [1], [4]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[3], [1], [7]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[3], [1], [7]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[3], [1], [7]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[3], [1], [4]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[3], [1], [4]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[43], [44], [45]
	CYP450 enzyme induction					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4], [5], [6]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[3], [1], [4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[3], [1], [4]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3], [1], [4]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[3], [1], [4]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[3], [1], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3], [1], [4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[12]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[3], [1], [4]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3], [1], [4]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4], [15]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3], [1], [4]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [18]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3], [1], [4]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3], [1], [4]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3], [1], [4]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[3], [1], [4]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[3], [1], [4]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[3], [1], [4]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[3], [1], [4]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[3], [1], [4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [1], [4]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[3], [1], [4]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[3], [1], [4]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3], [1], [4]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[3], [1], [4]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[3], [1], [4]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[3], [1], [4]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[3], [1], [4]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[4], [37]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[3], [1], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3], [1], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[3], [1], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[3], [1], [4]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3], [1], [4]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3], [1], [4]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [1], [4]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [1], [4]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3], [1], [4]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[3], [1], [4]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[3], [1], [4]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[4], [40]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[3], [1], [4]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[3], [1], [4]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [1], [4]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [52]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[53], [54], [55], [56], [57]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[53], [54], [55], [56], [57]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1], [22], [23]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1], [22], [23]

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