Details of Drug | MecDDI

Drug General Information (ID: D1068)
Drug Name		Miltefosine
Drug Type		Small molecule
Drug Synonymous		HDPC; HePC; Hexadecylphosphocholine; Hexadecylphosphorylcholine; Impavido; Miltefosina; Miltefosinum; Miltex; Baxter Oncology brand of miltefosine; Baxter brand of miltefosine; Miltefosin C; Prasfarma brand of miltefosine; D 18506; IN1227; D-18506; H-1850; M-7200; Miltefosina [INN-Spanish]; Miltefosine (INN); Miltefosine[INN:BAN]; Miltefosinum [INN-Latin]; N-Hexadecylphosphorylcholine; TF-002; Choline hydroxide, hexadecyl hydrogen phosphate, inner salt; Choline, hexadecyl hydrogen phosphate, inner salt; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; Choline phosphate, hexadecyl ester, hydroxide, inner salt; Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI); Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt; 1-Hexadecylphosphorylcholine; 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt; 3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide Click to Show/Hide
Disease Class		1F54: Leishmaniasis
Therapeutic Class		Antifungal Agents
Structure
Structure		3D Structure				2D Structure
Formula		C21H46NO4P
InChI		1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
InChIKey		PQLXHQMOHUQAKB-UHFFFAOYSA-N
Canonical SMILES		CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C
External Link
		Pubchem ID		3599
		CAS Number		58066-85-6
		CHEBI ID		75283
		TTD ID		D00FGR
		INTEDE ID		DR1092

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM009 Altered absorption (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Miltefosine
Affected gastrointestinal absorption
					Altered absorption (Unspecific)																																																																Drug Num: 8
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0450															Desogestrel															C22H30O															40973															Moderate															Inter Info													[1], [2], [3]
D0536															Drospirenone															C24H30O3															68873															Moderate															Inter Info													[3]
D0619															Ethinylestradiol															C20H24O2															5991															Moderate															Inter Info													[1], [2], [3]
D0922															Levonorgestrel															C21H28O2															13109															Moderate															Inter Info													[3]
D0485															Dienogest															C20H25NO2															68861															Moderate															Inter Info													[1], [2], [3]
D1157															Norgestrel															C21H28O2															13109															Moderate															Inter Info													[3]
D1154															Norethisterone															C20H26O2															6230															Moderate															Inter Info													[1], [2], [3]
D1156															Norgestimate															C23H31NO3															6540478															Moderate															Inter Info													[1], [2], [3]
Pharmacodynamic additive effects
					Increased risk of other adverse reactions (Unspecific)																																																																Drug Num: 1
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0789															Idelalisib															C22H18FN7O															11625818															Moderate															Inter Info													[4]

References
1	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
2	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
3	Product Information. Impavido (miltefosine). Paladin Therapeutics Inc, Wilmington, DE.
4	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.