Details of Drug

Details of Drug

 Drug General Information (ID: D1038)
  Drug Name
Methylnaltrexone
  Drug Type Small molecule
  Drug Synonymous
Methylnaltrexone; Methylnaltrexonium; Relistor; Mrz-2663; 83387-25-1; MNTX; Naltrexone MB; Methylnaltrexone ion; CHEMBL470617; Methylnaltrexone cation; N-Methylnaltrexone; Quaternary ammonium naltrexone; Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, (5alpha)-; MRZ 2663; 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinanium-6-one; SCHEMBL49356; GTPL7563; CHEMBL1186579; DTXSID20873339; CHEBI:136007; ZINC5764759; BDBM50278337; 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium; NCGC00378877-01; Q411515; (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one
    Click to Show/Hide
  Therapeutic Class Peripheral Opioid Receptor Antagonists
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H26NO4+
  InChI InChI=1S/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22?/m1/s1
  InChIKey JVLBPIPGETUEET-GAAHOAFPSA-O
  Canonical SMILES C[N+]1(CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)CC6CC6
  External Link
Pubchem ID 5361918

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
BM010  Transporter inhibition
  Relation Graph
 Full list of drugs interacting with Methylnaltrexone
      Affected cellular transport
   Transporter inhibition Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[1]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[2]
D1411
 
Risdiplam
 
C22H23N7O
 
118513932 
Moderate    Inter Info   
[3], [4], [5]
References
1 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Cerner Multum, Inc. "Australian Product Information.".
4 Product Information. Evrysdi (risdiplam). Genentech, South San Francisco, CA.
5 Yonezawa A, Inui K "Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics." Br J Pharmacol 164 (2011): 1817-25. [PMID: 21457222]