Details of Drug

Drug General Information (ID: D1033)
Drug Name	Methyl aminolevulinate (topical)
Drug Type	Small molecule
Drug Synonymous	Metvix; Aminolevulinic acid methyl ester; Methyl 5-aminolevulinate; Methyl delta-aminolevulinate; Methyl5-amino-4-oxopentanoate; Levulinic acid, 5-amino-, methyl ester; Pentanoic acid, 5-amino-4-oxo-, methyl ester; 5-Aminolevulinic acid methyl ester Click to Show/Hide
Disease Class	ED80: Acne vulgaris
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C6H11NO3
InChI	1S/C6H11NO3/c1-10-6(9)3-2-5(8)4-7/h2-4,7H2,1H3
InChIKey	YUUAYBAIHCDHHD-UHFFFAOYSA-N
Canonical SMILES	COC(=O)CCC(=O)CN
External Link
	Pubchem ID	157922
	CAS Number	33320-16-0
	CHEBI ID	724125
	TTD ID	D0OL6O

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Methyl aminolevulinate (topical)
Pharmacodynamic additive effects
	Increased risk of photosensitivity reactions					Drug Num: 118
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[3], [4], [5]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [4], [5]
D0018		Acitretin	C21H26O3	5284513	Moderate		Inter Info	[3], [4], [5]
D0024		Adapalene (topical)	C28H28O3	60164	Moderate		Inter Info	[3], [4], [5]
D0039		Alitretinoin (topical)	C20H28O2	449171	Moderate		Inter Info	[3], [4], [5]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[3], [4], [5]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[3], [4], [5]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [4], [5]
D0179		Bexarotene (topical)	C24H28O2	82146	Moderate		Inter Info	[3], [4], [5]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[3], [4], [5]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[3], [4], [5]
D0306		Cetuximab	NA	NA	Moderate		Inter Info	[3], [4], [5]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[3], [4], [5]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[3], [4], [5]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [4], [5]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[3], [4], [5]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[3], [4], [5]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [4], [5]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[3], [4], [5]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[3], [4], [5]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[3], [4], [5]
D0531		Doxycycline (topical)	C22H24N2O8	54671203	Moderate		Inter Info	[3], [4], [5]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[3], [4], [5]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[3], [4], [5]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[3], [4], [5]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[3], [4], [5]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[3], [4], [5]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[3], [4], [5]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[3], [4], [5]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[3], [4], [5]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [4], [5]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[3], [4], [5]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[3], [4], [5]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[3], [4], [5]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[3], [4], [5]
D0796		Imiquimod (topical)	C14H16N4	57469	Moderate		Inter Info	[3], [4], [5]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[3], [4], [5]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[3], [4], [5]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[3], [4], [5]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[3], [4], [5]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[3], [4], [5]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [4], [5]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[3], [6], [7]
D1029		Methoxsalen (topical)	C12H8O4	4114	Moderate		Inter Info	[3], [4], [5]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[3], [4], [5]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[3], [4], [5]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[3], [4], [5]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[3], [4], [5]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[3], [4], [5]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [4], [5]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[3], [4], [5]
D0374		Coal tar (topical)	NA	NA	Moderate		Inter Info	[3], [4], [5]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[3], [4], [5]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [4], [5]
D0589		Eravacycline	C27H31FN4O8	54726192	Moderate		Inter Info	[3], [4], [5]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[3], [4], [5]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[3], [4], [5]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [4], [5]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [4], [5]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[3], [4], [5]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[3], [4], [5]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[3], [4], [5]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[3], [4], [5]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[3], [4], [5]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[3], [4], [5]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[3], [4], [5]
D1071		Minocycline (topical)	C23H27N3O7	54675783	Moderate		Inter Info	[3], [4], [5]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[3], [4], [5]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[3], [4], [5]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[3], [4], [5]
D1220		Panitumumab	NA	NA	Moderate		Inter Info	[3], [4], [5]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[3], [4], [5]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[3], [4], [5]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[3], [4], [5]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[3], [4], [5]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[3], [4], [5]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[3], [4], [5]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3], [4], [5]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[3], [4], [5]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[3], [4], [5]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [4], [5]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[3], [4], [5]
D1636		Trifarotene (topical)	C29H33NO4	11518241	Moderate		Inter Info	[3], [4], [5]
D1648		Trioxsalen	C14H12O3	5585	Moderate		Inter Info	[3], [4], [5]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[3], [4], [5]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[3], [4], [5]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[3], [4], [5]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[3], [4], [5]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[3], [4], [5]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[3], [4], [5]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[3], [4], [5]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[3], [4], [5]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[8], [4], [9]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[3], [4], [5]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[3], [4], [5]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[3], [4], [5]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[3], [4], [5]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[3], [4], [5]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[3], [4], [5]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[3], [4], [5]
D1537		Tazarotene (topical)	C21H21NO2S	5381	Moderate		Inter Info	[3], [4], [5]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[3], [4], [5]
D1565		Tetracycline (topical)	C22H24N2O8	54675776	Moderate		Inter Info	[3], [4], [5]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[3], [4], [5]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[3], [4], [5]
D1582		Tigecycline	C29H39N5O8	54686904	Moderate		Inter Info	[3], [4], [5]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[3], [4], [5]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [4], [5]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[3], [4], [5]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[3], [4], [5]
D1627		Tretinoin (topical)	C20H28O2	444795	Moderate		Inter Info	[3], [4], [5]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[3], [4], [5]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[3], [4], [5]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[3], [4], [5]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3], [4], [5]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[3], [4], [5]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [4], [5]

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
6	Multum Information Services, Inc. Expert Review Panel.
7	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
8	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
9	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.

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