Details of Drug

Drug General Information (ID: D0978)
Drug Name	Mannitol
Drug Type	Small molecule
Drug Synonymous	Diosmol; Hexahydroxyhexane; Invenex; Isotol; MTL; Manita; Mannazucker; Mannidex; Mannigen; Mannistol; Mannit; Mannite; Osmitrol; Osmofundin; Osmosal; Resectisol; Cordycepic acid; Cpd without stereochemical designation; Manna sugar; Mannitol [USAN]; Marine Crystal; Resectisol In Plastic Container; M0044; Mannidex 16700; Mannogem 2080; D-mannite; D-mannitol; DL-Mannitol; MANNITOL 25%; Maniton-S; Mannitol (USP); Mannitol (VAN); Mannitol 10%; Mannitol 10% In Plastic Container; Mannitol 15%; Mannitol 15% In Plastic Container; Mannitol 20%; Mannitol 20% In Plastic Container; Mannitol 5%; Mannitol 5% In Plastic Container; OSMITROL 10% IN WATER IN PLASTIC CONTAINER; OSMITROL 15% IN WATER IN PLASTIC CONTAINER; OSMITROL 20% IN WATER IN PLASTIC CONTAINER; OSMITROL 5% IN WATER IN PLASTIC CONTAINER; Osmitrol (TN); Osmitrol 10% In Water; Osmitrol 15% In Water; Osmitrol 20% In Water; Osmitrol 5% In Water; SDM No. 35; SORBITOL-MANNITOL IN PLASTIC CONTAINER; Sorbitol-Mannitol; D-Mannitol (JP15); MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER; D-(-)-Mannitol; ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D; MANNITOL 15% DEXTROSE 5% IN SODIUM CHLORIDE 0.45%; MANNITOL 5% DEXTROSE 5% IN SODIUM CHLORIDE 0.12%; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol; (L)-Mannitol Click to Show/Hide
Disease Class	CA24: Bronchiectasis; GB60-GB6Z: Kidney failure
Therapeutic Class	Sweetening Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H14O6
InChI	1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChIKey	FBPFZTCFMRRESA-KVTDHHQDSA-N
Canonical SMILES	C(C(C(C(C(CO)O)O)O)O)O
External Link
	Pubchem ID	6251
	CAS Number	69-65-8
	CHEBI ID	16899
	TTD ID	D0P7EK
	INTEDE ID	DR2323
	VARIDT ID	DR00859

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM073 Increased risk of ototoxicity BM076 Increased risk of prolong QT interval BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Mannitol
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[122], [123], [124]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[21], [22], [125]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[21], [22], [125]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[21], [22], [125]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[22], [126], [127]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[123], [129]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[21], [22], [130]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[22], [126], [127]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[134]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[135], [136], [137]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[138], [139], [140]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[141]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[145]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[22], [126], [127]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[26], [21], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[22], [126], [127]
D0711		Garlic	NA	NA	Minor		Inter Info	[149], [150]
	Additive neuromuscular blocking effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[48], [49], [50]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[48], [49], [50]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[48], [49], [50]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[48], [49], [50]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[48], [49], [50]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[48], [49], [50]
	Increased risk of hypokalemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[108], [109], [6], [110], [111], [112], [113], [18], [114], [115]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[116], [117], [118]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[116], [117], [118]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[108], [109], [6], [110], [111], [112], [113], [18], [114], [115]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[116], [117], [118]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[116], [117], [118]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[116], [117], [118]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[116], [117], [118]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[116], [117], [118]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[116], [117], [118]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[116], [117], [118]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[116], [117], [118]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[116], [117], [118]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[116], [117], [118]
	Increased risk of hyponatremia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[128]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
	Increased risk of nephrotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[2], [14], [19]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0472		Diatrizoate	C11H9I3N2O4	2140	Moderate		Inter Info	[105], [106], [107]
D0831		Iodipamide	C20H14I6N2O6	3739	Moderate		Inter Info	[105], [106], [107]
D0832		Iodixanol	C35H44I6N6O15	3724	Moderate		Inter Info	[105], [106], [107]
D0833		Iohexol	C19H26I3N3O9	3730	Moderate		Inter Info	[105], [106], [107]
D0834		Iopamidol	C17H22I3N3O8	65492	Moderate		Inter Info	[105], [106], [107]
D0836		Iopromide	C18H24I3N3O8	3736	Moderate		Inter Info	[105], [106], [107]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Moderate		Inter Info	[105], [106], [107]
D0838		Ioversol	C18H24I3N3O9	3741	Moderate		Inter Info	[105], [106], [107]
D0839		Ioxilan	C18H24I3N3O8	3743	Moderate		Inter Info	[105], [106], [107]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[146], [147], [148]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[146], [147], [148]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[146], [147], [148]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[146], [147], [148]
D1209		Oxytetracycline	C22H24N2O9	54675779	Minor		Inter Info	[146], [147], [148]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[20], [21], [22], [23], [24], [25]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[119], [120], [121]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[119], [120], [121]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[119], [120], [121]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[119], [120], [121]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[119], [120], [121]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[119], [120], [121]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[119], [120], [121]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[119], [120], [121]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[119], [120], [121]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[142], [143], [144]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[142], [143], [144]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[119], [120], [121]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[142], [143], [144]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[131], [132], [133]

References
1	Athlin L, Domellof L, Holm S "Gentamicin treatment in severe surgical infections: serum levels, interactions, toxicity and efficacy." Acta Chir Scand 147 (1981): 225-30. [PMID: 7034430]
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