Details of Drug

Drug General Information (ID: D0953)
Drug Name	Lorlatinib
Drug Type	Small molecule
Drug Synonymous	Loratinib; UNII-OSP71S83EU; Lorlatinib,PF-06463922; OSP71S83EU; lorlantinib; 4clj; 4cli; Lorlatinib [USAN:INN]; Lorlatinib (JAN/USAN/INN); PF06463922(Lorlatinib); GTPL7476; SCHEMBL15261807; EX-A828; MolPort-035-789-724; KS-00000T6C; 2641AH; ZINC98208524; s7536; MFCD28144520; BDBM50018830; AKOS027250753; DB12130; CS-39 Click to Show/Hide
Disease Class	2C25: Lung cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C21H19FN6O2
InChI	1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
InChIKey	IIXWYSCJSQVBQM-LLVKDONJSA-N
Canonical SMILES	CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
External Link
	Pubchem ID	71731823
	CAS Number	1454846-35-5
	CHEBI ID	143117
	TTD ID	D04DYC
	INTEDE ID	DR0980

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction
Relation Graph

Full list of drugs interacting with Lorlatinib
Affected cellular transport
	Transporter induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[25], [29]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Major		Inter Info	[6], [2], [64], [65], [66]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[71]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[2], [1]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[2], [1]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[2], [1]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[2], [1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[213], [214]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[2], [1]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[37]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2], [1]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2], [1]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[1]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 358
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[2], [3]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[4]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[5], [6], [2], [7], [8], [9], [10], [11], [12], [13]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[14]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[6], [2], [15]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[2], [16]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[2]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[17]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[18]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[5], [6], [2], [7], [8], [9], [10], [11], [12], [13]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[19]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[20], [21], [22]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[2], [23], [24]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[5], [6], [2], [7], [8], [9], [10], [11], [12], [13]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[25], [26]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[27]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [28]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[10], [11], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[6], [2], [30]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[31]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[2], [32], [33]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[34]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [35]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[36]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[5], [6], [2], [7], [8], [9], [10], [11], [12], [13]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[2], [38]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[39]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[2], [40]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[6], [41]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[42]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[43]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[44]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [1]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[45]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[6], [58]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[59]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[6], [2], [60]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[5], [6], [2], [7], [8], [9], [10], [11], [12], [13]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[61]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[62]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[63]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[67]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[2], [1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[68]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[69]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[70]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[6], [2], [1]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[1]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[1]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[6], [2], [1]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[72]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[1]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[73], [74], [75], [5], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[89]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[90]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[91], [92]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[93]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[94], [95]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[6], [2], [96]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[97], [98], [99], [100], [101]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[102]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[6], [2], [1]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[6], [2], [1]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[2], [1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[1]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[103]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[2]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[104], [105], [106]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[107]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[108], [109]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[110]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[6], [2], [1]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[111]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[6], [2], [1]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[1]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[6], [2], [1]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[1]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[1]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[1]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[2], [1]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[112], [6], [113], [2], [114], [115], [116]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[1]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[113], [2], [164]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[1]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[165]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[6], [2], [166]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[6], [2], [1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[6], [2], [1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[112], [6], [2]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[1]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[1]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[167], [168], [169], [170], [171]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[6], [2], [1]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[172], [173], [174]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[6], [2], [1]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[175]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[176]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[177]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[6], [2], [178]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[1]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[6], [2], [179]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[1]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[180], [181]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[1]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[121], [131], [156]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[121], [131], [156]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[182]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[121], [131], [156]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[1]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[6], [2], [183]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[184]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[185]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[186]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[6], [2], [1]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[6], [2], [1]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[6], [2], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[73], [74], [75], [5], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[91], [92]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[187]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[180], [188]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[6], [2], [1]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[6], [2], [1]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[6], [2], [1]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[189]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[6], [2], [1]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[190]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[6], [2], [1]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[6], [2], [1]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[192], [193], [198]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[206]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[1]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[207]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[2], [208]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[1]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[209]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[210]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[6], [2], [1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[211]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[6], [2], [1]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[1]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[212]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[1]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[215]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[216]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[217]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[6], [2], [218]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[219]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[220]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[6], [221]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[6], [2], [222]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[223]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[224]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[6], [2], [1]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[6], [2], [225]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[226], [227]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[6], [228]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[229], [230], [163]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[6], [2], [1]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[231]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[121], [131], [156]
D0994		Melatonin	C13H16N2O2	896	Moderate		Inter Info	[6], [2], [1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[6], [2], [1]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[6], [2], [1]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[6], [2], [1]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[6], [2], [179]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[1]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[6], [2], [179]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[232], [233]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[234], [235], [236], [237]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[238]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [239]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[240]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[6], [2], [1]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[6], [2], [1]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[241]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[1]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[121], [131], [156]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[242]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[243]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[244], [245], [246], [247]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[244], [245], [246]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[6], [2], [248]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[249]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[6], [2], [1]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[250]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[2], [251]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[252]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[6], [2], [1]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[6], [2], [1]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[6], [2], [253]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[254], [6], [255], [256]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[1]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[1]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[121], [131], [156]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[2]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[6], [257], [258], [259], [260]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[261], [262], [12], [263], [264], [265]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[266]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[1]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[267], [268], [269]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[6], [2], [270]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[271]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[272]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[273]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[1]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[6], [2], [1]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[274]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[275]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[2]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[6], [2], [1]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[1]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[276], [277], [278], [279]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[6], [2], [280]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[281]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[6], [2], [222]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[6], [2], [282], [222]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[283]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2], [284], [285]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[1]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[6], [2], [1]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[6], [2], [286]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[6], [2], [1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[287]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[2], [288], [289]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[290], [291], [292], [293]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[1]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[294]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[6], [2], [295]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[1]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[6], [2], [1]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[1]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[2], [1]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [2], [296], [297], [298]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[73], [74], [75], [5], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[6], [2], [1]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[6], [2], [1]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[2], [299]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[6], [2], [1]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[300], [6], [2], [291], [301]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [302], [303]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[1]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[1]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[1]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[6], [2], [1]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[304]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[305]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[2], [1]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[306]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[2], [307], [308], [309]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[310], [311]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[293]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[312]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[313], [314], [315]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[316]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[317]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[318]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[319], [320], [321], [322]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[323]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[324], [325]
	UGT induction					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[6], [2], [1]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[6], [2], [1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[6], [2], [1]
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[6], [2], [1]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[6], [2], [1]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[6], [2], [1]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[6], [2], [1]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[6], [2], [1]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[6], [2], [1]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Moderate		Inter Info	[6], [2], [1]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[6], [2], [1]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[6], [2], [1]
D1377		Raltegravir	C20H21FN6O5	54671008	Moderate		Inter Info	[6], [2], [1]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[6], [2], [1]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[6], [2], [1]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[6], [2], [1]

References
1	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
4	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
5	Canadian Pharmacists Association.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
8	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
9	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
10	Product Information. Mycobutin (rifabutin). Pharmacia and Upjohn, Kalamazoo, MI.
11	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
12	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
13	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
14	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
15	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
16	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
17	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
18	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
19	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
20	Mir F, Pearce RE, Baig-Ansari N, et al. Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin.?Arch Dis Child. 2020;105(12):1208-1214. [PMID: 32404437]
21	Neu HC "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis 129 (1974): s123-31. [PMID: 4601187]
22	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
23	Kiechel JR, Lavene D, Guerret M, Comoy E, Godin M, Fillastre JP "Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 463-6. [PMID: 6360692]
24	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
25	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
26	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
27	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
28	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
29	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
30	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
31	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
32	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
33	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
34	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
35	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
36	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
37	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
38	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
39	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
40	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
41	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
42	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
43	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
44	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
45	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
46	Altice FL, Friedland GH, Cooney EL "Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone." AIDS 13 (1999): 957-62. [PMID: 10371177]
47	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
48	Bending MR, Skacel PO "Rifampicin and methadone withdrawal." Lancet 1 (1977): 1211. [PMID: 68314]
49	Finelli PF "Phenytoin and methadone tolerance." N Engl J Med 294 (1976): 227. [PMID: 1244546]
50	Holmes VF "Rifampin-induced methadone withdrawal in AIDS." J Clin Psychopharmacol 10 (1991): 443-4. [PMID: 2286719]
51	Kreek MJ, Garfield JW, Gutjahr CL, Giusti LM "Rifampin-induced methadone withdrawal." N Engl J Med 294 (1976): 1104-6. [PMID: 1256526]
52	Liu S-J, Wang RI "Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome." Am J Psychiatry 141 (1984): 1287-8. [PMID: 6486271]
53	Otero MJ, Fuertes A, Sanchez R, Luna G "Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert." AIDS 13 (1999): 1004-5. [PMID: 10371190]
54	Pinzani V, Faucherre V, Peyriere H, Blayac JP "Methadone withdrawal symptoms with nevirapine and efavirenz." Ann Pharmacother 34 (2000): 405-7. [PMID: 10917395]
55	Product Information. Diskets (methadone). Cebert Pharmaceuticals Inc, Birmingham, AL.
56	Raistrick D, Hay A, Wolff K "Methadone maintenance and tuberculosis treatment." BMJ 313 (1996): 925-6. [PMID: 8876100]
57	Tong TG, Pond SM, Kreek MJ, et al "Phenytoin-induced methadone withdrawal." Ann Intern Med 94 (1981): 349-51. [PMID: 7224382]
58	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
59	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
60	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
61	Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY.
62	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
63	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
64	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
65	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
66	Product Information. Sovaldi (sofosbuvir). Gilead Sciences, Foster City, CA.
67	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
68	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
69	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
70	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
71	Product Information. Gilotrif (afatinib). Boehringer Ingelheim, Ridgefield, CT.
72	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
73	Acosta EP, Henry K, Baken L, Page LM, Fletcher CV "Indinavir concentrations and antiviral effect." Pharmacotherapy 19 (1999): 708-12. [PMID: 10391416]
74	Barry M, Gibbons S, Back D, Mulcahy F "Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations." Clin Pharmacokinet 32 (1997): 194-209. [PMID: 9084959]
75	Brooks J, Daily J, Schwamm L "Protease inhibitors and anticonvulsants." AIDS Clin Care 9 (1997): 87,90. [PMID: 11364776]
76	Hugen PWH, Burger DM, Brinkman K, terHofstede HJM, Schuurman R, Koopmans PP, Hekster YA "Carbamazepine-indinavir interaction causes antiretroviral therapy failure." Ann Pharmacother 34 (2000): 465-70. [PMID: 10772431]
77	Liedtke MD, Lockhart SM, Rathbun RC "Anticonvulsant and antiretroviral interactions." Ann Pharmacother 38 (2004): 482-9. [PMID: 14970370]
78	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
79	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
80	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
81	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
82	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
83	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
84	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
85	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
86	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
87	Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40. [PMID: 10546783]
88	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9. [PMID: 10930147]
89	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
90	Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
91	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
92	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
93	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
94	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
95	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
96	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
97	Bullman J, Nicholls A, Van Landingham K, et al. "Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers." Epilepsia 52 (2011): 1351-8. [PMID: 21635243]
98	Gerber JG, Rosenkranz SL, Fichtenbaum CJ, et al. "Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study." J Acquir Immune Defic Syndr 39 (2005): 307-12. [PMID: 15980690]
99	Khandwala HM "Lipid lowering inefficacy of high-dose statin therapy due to concurrent use of phenytoin." South Med J 99 (2006): 1385-7. [PMID: 17233196]
100	Murphy MJ, Dominiczak MH "Efficacy of statin therapy: possible effect of phenytoin." Postgrad Med J 75 (1999): 359-60. [PMID: 10435174]
101	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
102	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
103	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
104	Kivisto KT, Lamberg TS, Neuvonen PJ "Interactions of buspirone with itraconazole and rifampicin: Effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone." Pharmacol Toxicol 84 (1999): 94-7. [PMID: 10068153]
105	Lamberg TS, Kivisto KT, Neuvonen PJ "Concentrations and effects of buspirone are considerably reduced by rifampicin." Br J Clin Pharmacol 45 (1998): 381-5. [PMID: 9578186]
106	Product Information. Buspar (buspirone). Bristol-Myers Squibb, Princeton, NJ.
107	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
108	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
109	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
110	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
111	Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA.
112	Caraco Y, Sheller J, Wood AJ "Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects." J Pharmacol Exp Ther 281 (1997): 330-6. [PMID: 9103514]
113	Cerner Multum, Inc. "Canadian Product Information.".
114	Product Information. Acetaminophen-Codeine Phosphate (acetaminophen-codeine). Qualitest Pharmaceuticals Inc, Huntsville, ON.
115	Product Information. Codeine Sulfate (codeine). Lannett Company Inc, Philadelphia, PA.
116	Product Information. Tuzistra XR (chlorpheniramine-codeine). Vernalis Pharmaceuticals Inc, Morristown, NJ.
117	Baciewicz AM "Oral contraceptive drug interactions." Ther Drug Monit 7 (1985): 26-35. [PMID: 2859674]
118	Baciewicz AM, Self TH "Rifampin drug interactions." Arch Intern Med 144 (1984): 1667-71. [PMID: 6380442]
119	Back DJ, Bates M, Bowden A, et al "The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy." Contraception 22 (1980): 495-503. [PMID: 7471739]
120	Back DJ, Breckenridge AM, Crawford FE, et al. "The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women." Contraception 21 (1980): 135-43. [PMID: 7189454]
121	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
122	Back DJ, Orme ML "Pharmacokinetic drug interactions with oral contraceptives." Clin Pharmacokinet 18 (1990): 472-84. [PMID: 2191822]
123	Barditch-Crovo P, Trapnell CB, Ette E, et al "The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive." Clin Pharmacol Ther 65 (1999): 428-38. [PMID: 10223781]
124	Bolt HM, Bolt M, Kappus H "Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man." Acta Endocrinol (Copenh) 85 (1977): 189-97. [PMID: 577076]
125	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
126	Cote J "Interaction of griseofulvin and oral contraceptives." J Am Acad Dermatol 22 (1990): 124-5. [PMID: 2298948]
127	Coulam CB, Annegers JF "Do anticonvulsants reduce the efficacy of oral contraceptives?" Epilepsia 20 (1979): 519-26. [PMID: 477641]
128	Crawford P, Chadwick DJ, Martin C, et al "The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids." Br J Clin Pharmacol 30 (1990): 892-6. [PMID: 2126946]
129	Curran MA "Drug interactions with the pill." Med J Aust 144 (1986): 670-1. [PMID: 3086681]
130	D'Arcy PF "Drug interactions with oral contraceptives." Drug Intell Clin Pharm 20 (1986): 353-62. [PMID: 3519141]
131	Dickinson BD, Altman RD, Nielsen NH, Sterling ML "Drug interactions between oral contraceptives and antibiotics." Obstet Gynecol 98(5 Pt 1) (2001): 853-60. [PMID: 11704183]
132	D'Arcy PF. Drug interactions with oral contraceptives. Drug Intell Clin Pharm. 1986;20(5):353-362. [PMID: 3519141]
133	Durr D, Stieger B, KullakUblick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K "St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4." Clin Pharmacol Ther 68 (2000): 598-604. [PMID: 11180019]
134	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
135	Furlan AJ, Rothner AD "Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113. [PMID: 4135275]
136	Gorski JC, Hamman MA, Wang Z, Vasvada N, Huang S, Hall SD "The effect of St. John's wort on the efficacy of oral contraception." Clin Pharmacol Ther 71 (2002): P25. [PMID: 14663455]
137	Hall SD, Wang Z, Huang SM, et al. "The interaction between St John's wort and an oral contraceptive." Clin Pharmacol Ther 74 (2003): 525-35. [PMID: 14663455]
138	Halpenny O, Bye A, Cranny A, Feely J, Daly PA "Influence of aminoglutethimide on plasma levels of medroxyprogesterone acetate." Med Oncol Tumor Pharmacother 7 (1990): 241-7. [PMID: 2149401]
139	Janz D, Schmidt D "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 1 (1974): 1113. [PMID: 4135275]
140	Klosterskov Jensen P, Saano V, Haring P, Svenstrup B, Menge GP "Possible interaction between oxcarbazepine and an oral contraceptive." Epilepsia 33 (1992): 1149-52. [PMID: 1464278]
141	Laengner H, Detering K "Letter: Anti-epileptic drugs and failure of oral contraceptives." Lancet 2 (1974): 600. [PMID: 4140317]
142	LeBel M, Masson E, Guilbert E, Colborn D, Paquet F, Allard S, Vallee F, Narang PK "Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone." J Clin Pharmacol 38 (1998): 1042-50. [PMID: 9824786]
143	Mattson RH, Cramer JA, Darney PD, Naftolin F "Use of oral contraceptives by women with epilepsy." JAMA 256 (1986): 238-40. [PMID: 3723710]
144	McDaniel PA, Caldroney RD "Oral contraceptives and griseofulvin interaction." Drug Intell Clin Pharm 20 (1986): 384. [PMID: 3709350]
145	Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112. [PMID: 9469685]
146	Mumford JP "Letter: Drugs affecting oral contraceptives." Br Med J 2 (1974): 333-4. [PMID: 4827122]
147	Nocke-finck L "Effects of rifampicin on menstral cycle and on estrogen excretion in patients taking oral contraceptives." JAMA 226 (1973): 378. [PMID: 4580141]
148	Notelovitz M, Tjapkes J, Ware M "Interaction between estrogen and dilantin in a menopausal woman." N Engl J Med 304 (1981): 788-9. [PMID: 6258075]
149	Pfrunder A, Schiesser M, Gerber S, Haschke M, Bitzer J, Drewe J "Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial." Br J Clin Pharmacol 56 (2003): 683-90. [PMID: 14616430]
150	Product Information. Premarin (conjugated estrogens). Wyeth-Ayerst Laboratories, Philadelphia, PA.
151	Murphy PA. St. John's wort and oral contraceptives: reasons for concern?.?J Midwifery Womens Health. 2002;47(6):447-450. doi:10.1016/s1526-9523(02)00321-5. [PMID: 12484666]
152	Skolnick JL, Stoler BS, Katz DB, Anderson WH "Rifampin, oral contraceptives, and pregnancy." JAMA 236 (1976): 1382. [PMID: 989097]
153	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
154	Szoka PR, Edgren RA "Drug interactions with oral contraceptives: compilation and analysis of an adverse experience report database." Fertil Steril 49 (1988): s31-8. [PMID: 3282933]
155	Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Br J Clin Pharmacol 55 (2003): 112-113. [PMID: 12534648]
156	van Dijke CP, Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J (Clin Res Ed) 288 (1984): 1125-6. [PMID: 2143563]
157	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]
158	Weaver K, Glasier A "Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill: a literature review." Contraception 59 (1999): 71-8. [PMID: 10361620]
159	Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J 288 (1984): 1125-6. [PMID: 6424759]
160	Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
161	Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65. [PMID: 10803456]
162	Zachariassen RD "Loss of oral contraceptive efficacy by concurrent antibiotic administration." Women Health 22 (1994): 17-26. [PMID: 7900401]
163	Lundgren S, Lonning PE, Aakvaag A, Kvinnsland S, Lnning PE "Influence of aminoglutethimide on the metabolism of medroxyprogesterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer." Cancer Chemother Pharmacol 27 (1990): 101-5. [PMID: 2249324]
164	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
165	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
166	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
167	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
168	Baker SD "Drug interactions with the taxanes." Pharmacotherapy 17(5 Pt 2) (1997): s126-32. [PMID: 9322879]
169	Komoroski BJ, Parise RA, Egorin MJ, Strom SC, Venkataramanan R "Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures." Clin Cancer Res 11(19 Pt 1) (2005): 6972-9. [PMID: 16203790]
170	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
171	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
172	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
173	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
174	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
175	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
176	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
177	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
178	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
179	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
180	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
181	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
182	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
183	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
184	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
185	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
186	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
187	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
188	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
189	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
190	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
191	Crews KR, Stewart CF, Jones-Wallace D, et al "Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy." Clin Cancer Res 8 (2002): 2202-9. [PMID: 12114421]
192	Di YM, Li CG, Xue CC, Zhou SF "Clinical drugs that interact with St. John's wort and implication in drug development." Curr Pharm Des 14 (2008): 1723-42. [PMID: 18673195]
193	Friedman HS, Petros WP, Friedman AH, et al "Irinotecan therapy in adults with recurrent or progressive malignant glioma." J Clin Oncol 17 (1999): 1516-25. [PMID: 10334539]
194	Innocenti F, Undevia SD, Ramirez J, et al. "A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital." Clin Pharmacol Ther 76 (2004): 490-502. [PMID: 15536463]
195	Kuhn JG "Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report." Oncology (Williston Park 16(8 Suppl 7) (2002): 33-40. [PMID: 12199631]
196	Hu ZP, Yang XX, Chen X, et al. A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.?Curr Drug Metab. 2007;8(2):157-171. [PMID: 17305494]
197	Mathijssen RH, Verweij J, De Bruijn P, Loos WJ, Sparreboom A "Effects of St. John's Wort on Irinotecan Metabolism." J Natl Cancer Inst 94 (2002): 1247-9. [PMID: 12189228]
198	Minami H, Lad TE, Nicholas MK, Vokes EE, Ratain MJ "Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies." Clin Cancer Res 5 (1999): 1325-30. [PMID: 10389915]
199	Murry DJ, Cherrick I, Salama V, et al. "Influence of phenytoin on the disposition of irinotecan: a case report." J Pediatr Hematol Oncol 24 (2002): 130-3. [PMID: 11990699]
200	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
201	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
202	Hofland KF, Hansen S, Sorensen M, et al. Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.?Acta Oncol. 2014;53(7):939-944. [PMID: 24456504]
203	Santos A, Zanetta S, Cresteil T, et al "Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans." Clin Cancer Res 6 (2000): 2012-20. [PMID: 10815927]
204	Yonemori K, Takeda Y, Toyota E, Kobayashi N, Kudo K "Potential interactions between irinotecan and rifampin in a patient with small-cell lung cancer." Int J Clin Oncol 9 (2004): 206-9. [PMID: 15221608]
205	Zamboni WC, Gajjar AJ, Heideman RL, et al "Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma." Clin Cancer Res 4 (1998): 783-9. [PMID: 9533548]
206	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
207	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
208	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
209	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
210	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
211	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
212	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
213	Gelosa P, Castiglioni L, Tenconi M, et.al "Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)" Pharmacol Res 135 (2018): 60-79. [PMID: 30040996]
214	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
215	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
216	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
217	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
218	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
219	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
220	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
221	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
222	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
223	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
224	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
225	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
226	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
227	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
228	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
229	Kobayashi K, Mimura N, Fujii H, et al "Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate." Clin Cancer Res 6 (2000): 3297-303. [PMID: 10955816]
230	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
231	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
232	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
233	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
234	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
235	Sitsen JM, Maris FA, Timmer CJ "Drug-drug interaction studies with mirtazapine and carbamazepine in healthy male subjects." Eur J Drug Metab Pharmacokinet 26 (2001): 109-21. [PMID: 11554425]
236	Spaans E, Van Den Heuvel MW, Schnabel PG, et al. "Concomitant use of mirtazapine and phenytoin: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 58 (2002): 423-9. [PMID: 12242602]
237	Timmer CJ, Sitsen JMA, Delbressine LP "Clinical pharmacokinetics of mirtazapine." Clin Pharmacokinet 38 (2000): 461-74. [PMID: 10885584]
238	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
239	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
240	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
241	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
242	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
243	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
244	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
245	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
246	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
247	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
248	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
249	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
250	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
251	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
252	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
253	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
254	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
255	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
256	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
257	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
258	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
259	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
260	Wong YWJ, Yeh C, Thyrum PT "The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine." J Clin Psychopharmacol 21 (2001): 89-93. [PMID: 11199955]
261	Fabre C, Criddle J, Nolder D, Klein JL "Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin." Trans R Soc Trop Med Hyg 99 (2005): 871-3. [PMID: 16099004]
262	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
263	Pukrittayakamee S, Prakongpan S, Wanwimolruk S, Clemens R, Looareesuwan S, White NJ "Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria." Antimicrob Agents Chemother 47 (2003): 1509-1513. [PMID: 12709315]
264	Twum-Barima Y, Carruthers SG "Quinidine-rifampin interaction." N Engl J Med 304 (1981): 1466-9. [PMID: 7231477]
265	Wanwimolruk S, Kang W, Coville PF, Viriyayudhakorn S, Thitiarchakul S "Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man." Br J Clin Pharmacol 40 (1995): 87-91. [PMID: 8527275]
266	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
267	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
268	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT "Rifampin decreases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 68 (2000): 495-500. [PMID: 11103752]
269	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
270	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
271	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
272	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
273	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
274	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
275	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
276	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
277	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
278	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
279	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
280	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
281	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
282	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
283	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
284	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
285	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
286	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
287	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
288	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
289	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
290	Biochem Pharmacol "Variable contribution of cytochromes P450 2D6, 2C9, and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes." Biochem Pharmacol 53 (1997): 171-8. [PMID: 9037249]
291	Kivisto KT, Villikka K, Nyman L, Anttila M, Neuvonen PJ "Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin." Clin Pharmacol Ther 64 (1998): 648-54. [PMID: 9871429]
292	Lien EA, Anker G, Lonning PE, et al "Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide." Cancer Res 50 (1990): 5851-7. [PMID: 2393854]
293	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
294	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
295	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
296	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
297	Teng R, Mitchell P, Butler K "Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects." Eur J Clin Pharmacol 69 (2013): 877-83. [PMID: 23093043]
298	Weeks P, Sieg A, Vahdat K, Raissi F, Nathan S "Improved ticagrelor antiplatelet effect on discontinuation of phenytoin." Ann Pharmacother 48 (2014): 644-7. [PMID: 24477376]
299	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
300	Berthou F, Dreano Y, Belloc C, Kangas L, Gautier JC, Beaune P "Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes." Biochem Pharmacol 47 (1994): 1883-95. [PMID: 8204106]
301	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
302	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
303	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
304	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
305	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
306	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
307	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
308	Villikka K, Kivisto KT, Luurila H, Neuvonen PJ "Rifampin reduces plasma concentrations and effects of zolpidem." Clin Pharmacol Ther 62 (1997): 629-34. [PMID: 9433391]
309	Vlase L, Popa A, Neag M, Muntean D, Baldea I, Leucuta SE "Pharmacokinetic Interaction Between Zolpidem and Carbamazepine in Healthy Volunteers." J Clin Pharmacol (2010):. [PMID: 21098143]
310	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
311	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
312	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
313	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
314	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
315	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
316	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
317	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
318	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
319	Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95. [PMID: 5428253]
320	Perucca E, Richens A "Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients." Br J Clin Pharmacol 8 (1979): 21-31. [PMID: 552293]
321	Perucca E, Ruprah M, Richens A, Park BK, Betteridge DJ, Hedges AM "Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects." Br J Clin Pharmacol 12 (1981): 592-6. [PMID: 6117310]
322	Reichel C, Skodra T, Nacke A, Spengler U, Sauerbruch T "The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans." Br J Clin Pharmacol 46 (1998): 535-9. [PMID: 9862241]
323	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
324	Miceli JJ, Anziano RJ, Robarge L, Hansen RA, Laurent A "The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s65-70. [PMID: 10771457]
325	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.

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