Details of Drug

Drug General Information (ID: D0921)
Drug Name	Levonordefrin
Drug Type	Small molecule
Drug Synonymous	levonordefrin; Corbadrine; Neo-Cobefrin; Nordefrin; 829-74-3; Corbadrinum; Corbadrina; alpha-Methylnoradrenaline; Corbadrinum [INN-Latin]; Corbadrina [INN-Spanish]; L-alpha-Methylnoradrenaline; Levonordefrin [USP]; Nordefrin, (-)-; UNII-V008L6478D; CHEBI:10304; 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol; Corbadrine (INN); Corbadrine [INN]; Levonordefrin (USP); V008L6478D; CAS-829-74-3; DSSTox_RID_81553; DSSTox_CID_26349 Click to Show/Hide
Therapeutic Class	Local Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C9H13NO3
InChI	1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
InChIKey	GEFQWZLICWMTKF-CDUCUWFYSA-N
Canonical SMILES	CC(C(C1=CC(=C(C=C1)O)O)O)N
External Link
	Pubchem ID	164739
	CAS Number	829-74-3
	CHEBI ID	10304
	TTD ID	D0E9VU

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM041 Additive hypertensive effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Levonordefrin
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[4], [5], [6]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[4], [5], [6]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[7], [8], [9]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[7], [9], [10]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[7], [9], [10]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[7], [9], [10]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[7], [9], [10]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[17], [18], [19]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[20], [21], [22]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[17], [18], [19]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[17], [18], [19]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[26], [27], [28]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[17], [18], [19]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[17], [18], [19]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[17], [18], [19]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[17], [18], [19]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[32]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[26], [27], [28]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[20], [21], [22]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[20], [21], [22]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[33], [34], [35]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[20], [21], [22]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[20], [21], [22]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[26], [27], [28]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[20], [21], [22]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[33], [34], [35]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[20], [21], [22]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[33], [34], [35]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[20], [21], [22]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[36]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[17], [18], [19]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[17], [18], [19]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[17], [18], [19]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[17], [18], [19]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[4], [10]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[26], [27], [28]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[20], [21], [22]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[4], [40], [41]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[17], [18], [19]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[33], [34], [35]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[17], [18], [19]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[17], [18], [19]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[20], [21], [22]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[33], [34], [35]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[33], [34], [35]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[20], [21], [22]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[20], [21], [22]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[20], [21], [22]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[33], [34], [35]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[40], [42], [43]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[26], [27], [28]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[20], [21], [22]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[33], [34], [35]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[26], [27], [28]
	Increased risk of hyperpyrexia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[11], [12], [13]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[29], [30], [31]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[23], [24], [25]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[23], [24], [25]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[23], [24], [25]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[37], [38], [39]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[37], [38], [39]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[37], [38], [39]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[23], [24], [25]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[14], [15], [16]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[14], [15], [16]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[14], [15], [16]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[14], [15], [16]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[14], [15], [16]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[14], [15], [16]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[14], [15], [16]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[14], [15], [16]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[14], [15], [16]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[14], [15], [16]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14], [15], [16]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[14], [15], [16]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[14], [15], [16]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[14], [15], [16]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[14], [15], [16]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[14], [15], [16]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[14], [15], [16]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[14], [15], [16]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[14], [15], [16]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[14], [15], [16]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[14], [15], [16]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[14], [15], [16]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[14], [15], [16]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[14], [15], [16]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[14], [15], [16]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[14], [15], [16]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[14], [15], [16]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[14], [15], [16]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[14], [15], [16]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[14], [15], [16]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[14], [15], [16]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[14], [15], [16]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[14], [15], [16]

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