Details of Drug

Drug General Information (ID: D0883)
Drug Name	Ketorolac (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Ketoralac; Ketorolaco; Ketorolacum; Macril; Ketorolaco [Spanish]; Ketorolacum [Latin]; RS 37619; Acular (TN); Ketorolac (INN); Ketorolac [INN:BAN]; RS-37619; Toradol (TN); (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; (+-)-Ketorolac; (+-)-isomer; (+/-)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid; 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro; 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; 5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid Click to Show/Hide
Disease Class	1A00-CA43: Postoperative inflammation
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C15H13NO3
InChI	1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
InChIKey	OZWKMVRBQXNZKK-UHFFFAOYSA-N
Canonical SMILES	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
External Link
	Pubchem ID	3826
	CAS Number	74103-06-3
	CHEBI ID	76223
	TTD ID	D0D9JW
	INTEDE ID	DR0908

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM050 Increased risk of bleeding BM091 Antagonize the effect of cholinergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Ketorolac (ophthalmic)
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1], [2], [3]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [3]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[1], [2], [3]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[1], [2], [3]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1], [2], [3]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[1], [2], [3]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[1], [2], [3]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[1], [2], [3]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1], [2], [3]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1], [2], [3]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[1], [2], [3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[1], [2], [3]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[1], [2], [3]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[1], [2], [3]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [2], [3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[1], [2], [3]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [3]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[1], [2], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [2], [3]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[1], [2], [3]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[1], [2], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[1], [2], [3]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1], [2], [3]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [3]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[1], [2], [3]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [3]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1], [2], [3]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1], [2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[1], [2], [3]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[1], [2], [3]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[1], [2], [3]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1], [2], [3]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[1], [2], [3]
D1380		Ramucirumab	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[1], [2], [3]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1], [2], [3]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[1], [2], [3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [2], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1], [2], [3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1], [2], [3]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [3]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[1], [2], [3]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1], [2], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[1], [2], [3]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[1], [2], [3]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[1], [2], [3]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1], [2], [3]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1], [2], [3]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[1], [2], [3]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[1], [2], [3]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[1], [2], [3]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[1], [2], [3]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[1], [2], [3]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0015		Acetylcholine	C7H16NO2+	187	Minor		Inter Info	[2], [4]

References
1	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
2	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
3	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
4	Holmes JM, Jay WM "The effect of preoperative flurbiprofen on miosis produced by acetylcholine during cataract surgery." Am J Ophthalmol 111 (1991): 735-8

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