Details of Drug

Details of Drug

 Drug General Information (ID: D0842)
  Drug Name
Ipratropium
  Drug Type Small molecule
  Drug Synonymous
Aerodose; Atrovent; Atrovent Hfa; Ipatropium Bromide; Ipratropium bromide; X8M; Apo-Ipravent; Apovent (TN); Atrovent (TN); Kendral-Ipratropium; [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] (2R)-3-hydroxy-2-phenylpropanoate; (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane; (8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate; 3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azoniabicyclo[3.2.1]octane
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  Disease Class CA22: Chronic obstructive pulmonary disease
  Therapeutic Class Bronchodilators
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C20H30NO3+
  InChI 1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1/t16-,17+,18?,19?,21?
  InChIKey OEXHQOGQTVQTAT-BZQJJPTISA-N
  Canonical SMILES CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C
  External Link
Pubchem ID 657309
CAS Number 60205-81-4
CHEBI ID 5956
TTD ID D0S0AS
VARIDT ID DR00277

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM033  Additive anticholinergic effects
BM091  Antagonize the effect of cholinergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ipratropium
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[11], [12], [13]
      Pharmacodynamic additive effects
   Additive anticholinergic effects Drug Num:  83
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0160
 
Benzatropine
 
C21H25NO
 
1201549 
Moderate    Inter Info   
[2], [4], [5]
D0351
 
Clemastine
 
C21H26ClNO
 
26987 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0019
 
Aclidinium
 
C26H30NO4S2+
 
11434515 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0020
 
Acrivastine
 
C22H24N2O2
 
5284514 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[2], [4], [5]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0135
 
Azatadine
 
C20H22N2
 
19861 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0154
 
Belladonna
 
C34H42N2O4
 
265028 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0183
 
Biperiden
 
C21H29NO
 
2381 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0259
 
Carbinoxamine
 
C16H19ClN2O
 
2564 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0316
 
Chlorcyclizine
 
C18H21ClN2
 
2710 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0323
 
Chlorpheniramine
 
C16H19ClN2
 
2725 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0353
 
Clidinium
 
C22H26NO3+
 
2784 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0397
 
Cyclizine
 
C18H22N2
 
6726 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0398
 
Cyclobenzaprine
 
C20H21N
 
2895 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0456
 
Dexbrompheniramine
 
C16H19BrN2
 
16960 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0482
 
Dicyclomine
 
C19H35NO2
 
3042 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[2], [4], [5]
D0532
 
Doxylamine
 
C17H22N2O
 
3162 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0655
 
Fesoterodine
 
C26H37NO3
 
6918558 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0662
 
Flavoxate
 
C24H25NO4
 
3354 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0733
 
Glycopyrronium
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[2], [4], [5]
D0734
 
Glycopyrronium (topical)
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[2], [4], [5]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0759
 
Homatropine
 
C16H21NO3
 
5282593 
Moderate    Inter Info   
[2], [4], [5]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0782
 
Hyoscyamine
 
C17H23NO3
 
154417 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D0987
 
Meclizine
 
C25H27ClN2
 
4034 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1000
 
Mepenzolate
 
C21H26NO3+
 
4057 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1006
 
Mepyramine
 
C17H23N3O
 
4992 
Moderate    Inter Info   
[2], [4], [5]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1031
 
Methscopolamine
 
C18H24NO4+
 
71183 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1188
 
Orphenadrine
 
C18H23NO
 
4601 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1202
 
Oxybutynin
 
C22H31NO3
 
4634 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1264
 
Phenindamine
 
C19H19N
 
11291 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1282
 
Phenyltoloxamine
 
C17H21NO
 
7077 
Moderate    Inter Info   
[2], [4], [5]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1347
 
Procyclidine
 
C19H29NO
 
4919 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1354
 
Propantheline
 
C23H30NO3+
 
4934 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1450
 
Scopolamine
 
C17H21NO4
 
3000322 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1590
 
Tiotropium
 
C19H22NO4S2+
 
5487427 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1641
 
Trihexyphenidyl
 
C20H31NO
 
5572 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1649
 
Tripelennamine
 
C16H21N3
 
5587 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1650
 
Triprolidine
 
C19H22N2
 
5282443 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1665
 
Umeclidinium
 
C29H34NO2+
 
11519070 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
D1656
 
Trospium
 
C25H30NO3+
 
5284632 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0562
 
Eluxadoline
 
C32H35N5O5
 
11250029 
Moderate    Inter Info   
[11], [16]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0308
 
Cevimeline
 
C10H17NOS
 
83898 
Moderate    Inter Info   
[9], [10]
D0015
 
Acetylcholine
 
C7H16NO2+
 
187 
Moderate    Inter Info   
[14], [15]
D0175
 
Bethanechol
 
C7H17N2O2+
 
2370 
Moderate    Inter Info   
[9], [10]
D0256
 
Carbamoylcholine (ophthalmic)
 
C6H15N2O2+
 
2551 
Moderate    Inter Info   
[14], [15]
D0440
 
Demecarium (ophthalmic)
 
C32H52N4O4+2
 
5966 
Moderate    Inter Info   
[14], [15]
D0546
 
Echothiophate (ophthalmic)
 
C9H23NO3PS+
 
10548 
Moderate    Inter Info   
[14], [15]
D0856
 
Isoflurophate (ophthalmic)
 
C6H14FO3P
 
5936 
Moderate    Inter Info   
[14], [15]
D1286
 
Physostigmine (ophthalmic)
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[14], [15]
D1288
 
Pilocarpine
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[9], [10]
D1289
 
Pilocarpine (ophthalmic)
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[14], [15]
D1362
 
Prucalopride
 
C18H26ClN3O3
 
3052762 
Moderate    Inter Info   
[17], [18]
References
1 Cole JM, Sheehan AH, Jordan JK "Concomitant use of ipratropium and tiotropium in chronic obstructive plmonary disease." Ann Pharmacother 46 (2012): 1717-21. [PMID: 23170031]
2 Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
3 Product Information. Atrovent (ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
4 Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
5 Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
6 Product Information. Spiriva (tiotropium). Boehringer Ingelheim, Ridgefield, CT.
7 Product Information. Tudorza Pressair (aclidinium). Forest Pharmaceuticals, St. Louis, MO.
8 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
9 Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
10 Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
11 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
12 Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
13 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
14 Multum Information Services, Inc. Expert Review Panel.
15 Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
16 Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
17 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
18 Product Information. Resotran (prucalopride). Janssen Pharmaceuticals, Titusville, NJ.