Details of Drug

Drug General Information (ID: D0841)
Drug Name	Ipilimumab
Drug Type	Monoclonal antibody
Drug Synonymous	BMS-734016; MDX-010; MDX-101; Yervoy (TN) Click to Show/Hide
Disease Class	2C30: Melanoma
Therapeutic Class	Antineoplastics
External Link
External Link	TTD ID	D07BVI

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM043 Additive immunosuppressive effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy
Relation Graph

Full list of drugs interacting with Ipilimumab
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[55]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[25], [26], [15], [16], [27], [2], [28], [29], [30], [31]
	Increased risk of bleeding					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2], [3]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1], [2], [3]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2], [3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2], [3]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2], [3]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2], [3]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2], [3]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3]
	Increased risk of hepatotoxicity					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[4]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[5]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[6], [7], [8]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[6], [7], [8]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[9]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[35]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[36], [37]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[16], [2], [38]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[39], [40], [41], [42]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[39], [40], [41], [42]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[43]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[44], [45]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[13], [14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[2], [46]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[47]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[39], [40], [41], [42]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [2], [48], [49], [50]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[51], [52]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [53]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[54]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[13], [14], [15], [16], [2], [17], [18], [19], [20], [21], [22], [23], [24]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[56], [57]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [58]
	Increased risk of peripheral neuropathy					Drug Num: 75
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[10], [11], [12]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[10], [11], [12]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[10], [11], [12]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[32], [33], [34]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[10], [11], [12]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [12]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[10], [11], [12]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[10], [11], [12]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[10], [11], [12]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[10], [11], [12]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[10], [11], [12]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[10], [11], [12]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[10], [11], [12]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[10], [11], [12]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[10], [11], [12]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[10], [11], [12]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[10], [11], [12]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[10], [11], [12]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[10], [11], [12]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[10], [11], [12]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[10], [11], [12]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[10], [11], [12]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[10], [11], [12]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[10], [11], [12]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[10], [11], [12]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[10], [11], [12]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[10], [11], [12]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[10], [11], [12]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[10], [11], [12]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[10], [11], [12]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[10], [11], [12]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[10], [11], [12]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[10], [11], [12]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[10], [11], [12]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[10], [11], [12]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[10], [11], [12]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[10], [11], [12]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[10], [11], [12]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[10], [11], [12]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[10], [11], [12]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[10], [11], [12]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[10], [11], [12]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[10], [11], [12]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[10], [11], [12]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[10], [11], [12]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[10], [11], [12]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[10], [11], [12]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[10], [11], [12]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[10], [11], [12]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[10], [11], [12]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[10], [11], [12]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[10], [11], [12]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[10], [11], [12]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[10], [11], [12]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[10], [11], [12]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[10], [11], [12]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[10], [11], [12]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[10], [11], [12]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[32], [59]

References
1	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
4	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
5	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
6	Canadian Pharmacists Association.
7	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
8	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
9	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
10	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
11	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
12	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
13	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
14	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
15	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
16	Cerner Multum, Inc. "Australian Product Information.".
17	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
18	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
19	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
20	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
21	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
22	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
23	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
24	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
25	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
26	Arbour KC, Mezquita L, Long N, et al. "Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer." J Clin Oncol 36 (2018): 2872-2878. [PMID: 30125216]
27	Cerner Multum, Inc. "Canadian Product Information.".
28	Jove M, Vilarino N, Nadal E "Impact of baseline steroids on efficacy of programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade in patients with advanced non-small cell lung cancer." Transl Lung Cancer Res 8 (2019): S364-8. [PMID: 32038916]
29	Scott SC, Pennell NA "Early use of systemic corticosteroids in patients with advanced NSCLC treated with nivolumab." J Thorac Oncol 13 (2018): 1771-5. [PMID: 29935305]
30	Fuca G, Galli G, Poggi M, et.al "Modulation of peripheral blood immune cells by early use of steroids and its association with clinical outcomes in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors." ESMO Open 4 (2019): e000457. [PMID: 30964126]
31	Horvat TZ, Adel NG, Dand TO, et.al "Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center." J Clin Oncol 33 (2015): 3193-8. [PMID: 26282644]
32	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
33	Cavaletti G, Jakubowiak AJ "Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies." Leuk Lymphoma 51 (2010): 1178-87. [PMID: 20497001]
34	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
35	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
36	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
37	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
38	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
39	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
40	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
41	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
42	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
43	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
44	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
45	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
46	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
47	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
48	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
49	Gilead Sciences, Inc "About Remdesivir.".
50	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
51	Product Information. Yervoy (ipilimumab). Bristol-Myers Squibb, Princeton, NJ.
52	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
53	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
54	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
55	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
56	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
57	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
58	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
59	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence