Details of Drug

Drug General Information (ID: D0792)
Drug Name	Iloprost
Drug Type	Small molecule
Drug Synonymous	Ciloprost; Endoprost; Ilomedin; Ilomedine; Iloprostum; Ventavis; Iloprostum [Latin]; ZK 36374; E-1030; Iloprost (INN); Iloprost [BAN:INN]; SH-401; Ventavis (TN); ZK-36374; ZK-363775; [3H]-Iloprost; (16R,S)-Methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I(sub 2); (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid; (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric acid; (E)-5-(3aS,4R,5R,6aS)-5-Hydroxy-4((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-inyl)perhydropentalen-2-yliden)valeriansaeure Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H32O4
InChI	1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1
InChIKey	HIFJCPQKFCZDDL-ACWOEMLNSA-N
Canonical SMILES	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
External Link
	Pubchem ID	5311181
	CAS Number	78919-13-8
	CHEBI ID	63916
	TTD ID	D05ZTH
	VARIDT ID	DR00099

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM042 Additive hypotensive effects BM050 Increased risk of bleeding BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Iloprost
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[11], [155], [156]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 133
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[33]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[11], [36], [37]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[39]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[11], [36], [37]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[11], [36], [37]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[11], [36], [37]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[11], [36], [37]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[48], [49], [50]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[51], [52], [53]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[11], [36], [37]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[11], [36], [37]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[11], [36], [37]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[11], [36], [37]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[11], [36], [37]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[11], [36], [37]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[51], [52], [53]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[51], [52], [53]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[11], [36], [37]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[11], [36], [37]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[11], [36], [37]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[11], [36], [37]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[11], [36], [37]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[11], [36], [37]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[11], [36], [37]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[97], [36], [37]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[11], [36], [37]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[11], [36], [37]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[11], [36], [37]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[11], [36], [37]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[11], [36], [37]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[11], [36], [37]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[11], [36], [37]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[11], [36], [37]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[11], [36], [37]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[11], [36], [37]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[11], [36], [37]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[11], [36], [37]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[11], [36], [37]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[11], [36], [37]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[48], [100], [101]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[11], [36], [37]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[102], [103], [104]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[11], [36], [37]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[11], [36], [37]
D0213		Bromotheophylline	C7H7BrN4O2	11808	Moderate		Inter Info	[11], [36], [37]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[25], [11], [105]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[11], [36], [37]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[11], [36], [37]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[11], [36], [37]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[11], [36], [37]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[25], [11], [105]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[11], [36], [37]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[11], [36], [37]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[11], [36], [37]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[25], [11], [105]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[97], [36], [37]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[97], [36], [37]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[11], [36], [37]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[11], [36], [37]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[11], [36], [37]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[11], [36], [37]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[11], [36], [37]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[11], [36], [37]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[142]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[11], [36], [37]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[11], [36], [37]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[143], [144], [145]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[11], [36], [37]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[11], [36], [37]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[147], [148], [149]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[11], [36], [37]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[11], [36], [37]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[11], [36], [37]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[150]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[11], [36], [37]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[11], [36], [37]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[11], [36], [37]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[11], [36], [37]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[11], [36], [37]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[11], [36], [37]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[11], [36], [37]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[11], [36], [37]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[11], [36], [37]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[11], [36], [37]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[11], [36], [37]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[11], [36], [37]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[11], [36], [37]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[11], [36], [37]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[11], [36], [37]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[11], [36], [37]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[11], [36], [37]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[157], [158]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[11], [36], [37]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[11], [36], [37]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[11], [36], [37]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[11], [36], [37]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[11], [36], [37]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[11], [36], [37]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[11], [36], [37]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[11], [36], [37]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[11], [36], [37]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[11], [36], [37]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[97], [36], [37]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[97], [36], [37]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[11], [36], [37]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[11], [36], [37]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[11], [36], [37]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[97], [36], [37]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[11], [36], [37]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[102], [103], [104]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[11], [36], [37]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[11], [36], [37]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[11], [36], [37]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[11], [36], [37]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[11], [36], [37]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[11], [36], [37]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[11], [36], [37]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[11], [36], [37]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [100], [137], [138]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[11], [36], [37]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[11], [36], [37]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[11], [36], [37]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[102], [103], [104]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[11], [36], [37]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[177], [178]
	Increased risk of bleeding					Drug Num: 126
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[8]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[9]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[10]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[11], [12]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[11], [13]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[14]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[15]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[16]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[17], [18]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[19]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[20], [21], [11], [22]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[11], [17], [23]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[17], [24]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[25], [11], [26]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[27]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[28]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[11], [29], [30]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[31]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[17]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[32]
D1613		Tositumomab	NA	NA	Major		Inter Info	[34], [35]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[34], [35]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[36], [37], [38]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[36], [37], [38]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[36], [37], [38]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[36], [37], [38]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[36], [37], [38]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[36], [37], [38]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[54], [55], [56]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[57]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[36], [37], [38]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[96]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[36], [37], [38]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[54], [55], [56]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[54], [55], [56]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[36], [37], [38]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[36], [37], [38]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[36], [37], [38]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[36], [37], [38]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[36], [37], [38]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[36], [37], [38]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[36], [37], [38]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[54], [55], [56]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[36], [37], [38]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[11], [98], [99]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[36], [37], [38]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[36], [37], [38]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[36], [37], [38]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[36], [37], [38]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[36], [37], [38]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[36], [37], [38]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[36], [37], [38]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[36], [37], [38]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[36], [37], [38]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[17], [106]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[36], [37], [38]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[36], [37], [38]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[126]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[36], [37], [38]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[54], [55], [56]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[11], [146]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[11], [98], [99]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[36], [37], [38]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[36], [37], [38]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[36], [37], [38]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[36], [37], [38]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[151], [152], [153]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[36], [37], [38]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[11], [154]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[36], [37], [38]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[36], [37], [38]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[36], [37], [38]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[36], [37], [38]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[54], [55], [56]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[36], [37], [38]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[36], [37], [38]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[36], [37], [38]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[36], [37], [38]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[36], [37], [38]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[36], [37], [38]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[36], [37], [38]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[17], [159]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[36], [37], [38]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[36], [37], [38]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[36], [37], [38]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[57]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[36], [37], [38]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[36], [37], [38]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[54], [55], [56]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[36], [37], [38]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[36], [37], [38]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[36], [37], [38]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[57]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[58], [59], [60], [61], [25], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[151], [161], [11], [162], [163], [164], [165], [115], [166], [167], [168], [169], [170], [171], [172], [152], [173], [174], [153], [175]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[36], [37], [38]
D0253		Capsicum	NA	NA	Minor		Inter Info	[115]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[115], [176], [120]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[139], [140], [141]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[160], [100]

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