Details of Drug

Drug General Information (ID: D0765)
Drug Name		Human immunoglobulin G (intravenous)
Drug Type		Protein/peptide
Drug Synonymous		145464-27-3; 7J34AKZ6YU; Immune globulin Intravenous; Immune globulin Intravenous Pentetate; Immune globulin Intravenous Pentetate [USAN]; Immunoglobulin G (human polyclonal Macroscint), disufide with human polyclonal Macroscint light chain, dimer, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycine conjugate;; Immunoglobulin G (human polyclonal Macroscint), disulfide with human polyclonal Macroscint light chain, dimer, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycine conjugate; Macroscint; RWJ 28299 Click to Show/Hide
Therapeutic Class		Immune Globulins

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM072 Increased risk of nephrotoxicity BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Human immunoglobulin G (intravenous)
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0548		Eculizumab	NA	NA	Minor		Inter Info	[5]
	Increased risk of nephrotoxicity					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0075		Amphotericin B	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0142		Bacitracin	C66H103N17O16S	10909430	Major		Inter Info	[1], [2], [3]
D0145		Balsalazide	C17H15N3O6	54585	Major		Inter Info	[1], [2], [3]
D0252		Capreomycin	C50H88N28O15	3000502	Major		Inter Info	[1], [2], [3]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1], [2], [3]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [2], [3]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1], [2], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1], [2], [3]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3]
D0623		Etidronic acid	C2H8O7P2	3305	Major		Inter Info	[1], [2], [3]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2], [3]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2], [3]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2], [3]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[1], [2], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [2], [3]
D0783		Ibandronate	C9H23NO7P2	60852	Major		Inter Info	[1], [2], [3]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2], [3]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [2], [3]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1], [2], [3]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2], [3]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [2], [3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [2], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2], [3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2], [3]
D1009		Mesalazine	C7H7NO3	4075	Major		Inter Info	[1], [2], [3]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1], [2], [3]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[1], [2], [3]
D1091		Moxetumomab Pasudotox	NA	NA	Major		Inter Info	[1], [2], [3]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2], [3]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2], [3]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3]
D1173		Olsalazine	C14H10N2O6	22419	Major		Inter Info	[1], [2], [3]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2], [3]
D1217		Pamidronic acid	C3H11NO7P2	4674	Major		Inter Info	[1], [2], [3]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1], [2], [3]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1], [2], [3]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1], [2], [3]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1], [2], [3]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1], [2], [3]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[1], [2], [3]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2], [3]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1], [2], [3]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2], [3]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1], [2], [3]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Major		Inter Info	[1], [2], [3]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0501		Dinutuximab	NA	NA	Major		Inter Info	[4]
D1876		Ravulizumab	NA	NA	Minor		Inter Info	[6], [4], [7]

References
1	Guo X, Nzerue C "How to prevent, recognize, and treat drug-induced nephrotoxicity.".
2	Centers for Disease Control and Prevention (CDC). Renal insufficiency and failure associated with immune globulin intravenous therapy--United States, 1985-1998.?MMWR Morb Mortal Wkly Rep. 1999;48(24):518-521. [PMID: 10401909]
3	Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Soliris (eculizumab). Alexion Pharmaceuticals Inc, Cheshire, CT.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Product Information. Ultomiris (ravulizumab). Alexion Pharmaceuticals Inc, Cheshire, CT.

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