Details of Drug

Drug General Information (ID: D0759)
Drug Name	Homatropine
Drug Type	Small molecule
Drug Synonymous	HOMATROPINE; 87-00-3; Homatropin; DL-HOMATROPINE; Homoatropine; Mandelyltropeine; Homotropine; Mandelytropeine; CHEBI:5747; Benzeneacetic acid, a-hydroxy-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; 1aH,3aH-Tropan-3a-ol mandelate (ester) hydrobromide; Mandelic acid, 3d-tropanyl ester; Omatropina; Methylhomatropinum; Omatropina [DCIT]; 3alpha-Tropylmandelat; Tropinmandelsaeureester; NCGC00179630-03; Homatropine [INN:BAN]; DL-Mandelsaeure-tropylester; Tropine, mandelate (ester); s ethyl; EINECS 201-716-8; (+-)-Homatropine; BRN 0087959; Prestwick0_000062; Prestwick1_000062; Prestwick2_000062; Prestwick3_000062; (RS)-3alpha(1alphaH,5alphaH)-Tropanylmandelat; DSSTox_CID_24014; DSSTox_RID_80098; DSSTox_GSID_44014; SCHEMBL23969; BSPBio_000243; 5-21-01-00234 (Beilstein Handbook Reference); SPBio_002164; BPBio1_000269; MEGxp0_001876; CHEMBL1618018; DTXSID6044014; SCHEMBL15275620; ACon1_000253; CHEBI:91858; DTXSID00858826; Tox21_113104; 6348AF; AC-1301; DB11181; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate; CAS-87-00-3; NCGC00179630-01; NCGC00179630-02; C07814; AB00694561_08; 087H003; Q1038115; BRD-A74975734-004-02-4; BRD-A74975734-004-10-7; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, mandelate (ester); (3-exo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl hydroxy(phenyl)acetate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate; alpha-Hydroxybenzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3alpha-yl ester; 16175-57-8 Click to Show/Hide
Therapeutic Class	Mydriatics
Structure
Structure	3D Structure		2D Structure
Formula	C16H21NO3
InChI	InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14?,15?
InChIKey	ZTVIKZXZYLEVOL-DGKWVBSXSA-N
Canonical SMILES	CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(C3=CC=CC=C3)O
External Link
External Link	Pubchem ID	5282593

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM033 Additive anticholinergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM054 Increased risk of GI mucosal injury/bleeding risk BM061 Increased risk of hyperpyrexia BM091 Antagonize the effect of cholinergic agents
Relation Graph

Full list of drugs interacting with Homatropine
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[18], [19], [20]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[18], [19], [20]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[18], [19], [20]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[18], [19], [20]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[18], [19], [20]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[18], [19], [20]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[24], [25], [26]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[18], [19], [20]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[18], [19], [20]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[18], [19], [20]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[18], [19], [20]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[18], [19], [20]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[18], [19], [20]
	Additive CNS depression effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[7], [8], [9]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[10], [11], [12]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[21], [22], [23]
D1183		Opium	NA	NA	Moderate		Inter Info	[21], [22], [23]
	Additive hypertensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[27], [28], [29]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[1], [2], [3]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[4], [5], [6]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[13], [14]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[15]
D0175		Bethanechol	C7H17N2O2+	2370	Moderate		Inter Info	[16], [17]
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[13], [14]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[13], [14]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[13], [14]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[15]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[15]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[13], [14]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[15]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[30], [31], [32]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[13], [14]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[15]

References
1	Leijonmarck CE, Raf L "Ulceration of the small intestine due to slow-release potassium chloride tablets." Acta Chir Scand 151 (1985): 273-8. [PMID: 4013604]
2	Lofgren RP, Rothe PR, Carlson GJ "Jejunal perforation associated with slow-release potassium chloride therapy." South Med J 75 (1982): 1154-5. [PMID: 7123349]
3	Weiss SM, Rutenberg HL, Paskin DL, Zaren HA "Gut lesions due to slow-release KCI tablets." N Engl J Med 296 (1977): 111-2. [PMID: 830293]
4	McMahon FG, Ryan JR, Akdamar K, Ertan A "Upper gastrointestinal lesions after potassium chloride supplements: a controlled clinical trial." Lancet 2 (1982): 1059-61. [PMID: 6127542]
5	Product Information. K-Dur (potassium chloride). Schering Laboratories, Kenilworth, NJ.
6	Wynn V "Potassium chloride and bowel ulceration." Br Med J 5477 (1965): 1546. [PMID: 5850476]
7	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
8	Product Information. Topamax (topiramate). Ortho Pharmaceutical Corporation, Raritan, NJ.
9	Product Information. Ionamin (phentermine). Rhone-Poulenc Rorer, Collegeville, PA.
10	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
11	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
12	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
13	Multum Information Services, Inc. Expert Review Panel.
14	Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
15	Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
16	Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
17	Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
18	Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
19	Mann SC, Boger WP "Psychotropic drugs, summer heat and humidity, and hyperplexia: a danger restated." Am J Psychiatry 135 (1978): 1097-100. [PMID: 29501]
20	Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]
21	Product Information. Exalgo (hydromorphone). Covidien, Mansfield, MA.
22	Product Information. Apadaz (acetaminophen-benzhydrocodone). KemPharm, Inc, Coralville, IA.
23	Product Information. Lortab (acetaminophen-hydrocodone). Akorn Inc, Buffalo Grove, IL.
24	Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
25	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
26	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
27	Levine MA, Leenen FH "Role of vagal activity in the cardiovascular responses to phenylephrine in man." Br J Clin Pharmacol 33 (1992): 333-6
28	Daelman F, Andrejak M, Rajaonarivony D, Bryselbout E, Jezraoui P, Ossart M "Phenylephrine eyedrops, systemic atropine and cardiovascular adverse events." Therapie 49 (1994): 467
29	Lai YK "Adverse effect of intraoperative phenylephrine 10%: case report." Br J Ophthalmol 73 (1989): 468-9
30	Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
31	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
32	Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42. [PMID: 12028169]

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