Details of Drug

Drug General Information (ID: D0742)
Drug Name	Guanabenz
Drug Type	Small molecule
Drug Synonymous	GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine Click to Show/Hide
Disease Class	BA00: Essential hypertension
Therapeutic Class	Sympatholytics
Structure
Structure	3D Structure		2D Structure
Formula	C8H8Cl2N4
InChI	1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
InChIKey	WDZVGELJXXEGPV-YIXHJXPBSA-N
Canonical SMILES	C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
External Link
	Pubchem ID	5702063
	CAS Number	60329-03-5
	CHEBI ID	5553
	TTD ID	D0L4HY
	INTEDE ID	DR0794
	VARIDT ID	DR01410

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Guanabenz
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[33]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[53]
	Additive hypotensive effects					Drug Num: 133
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[2]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[3], [4], [5]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[3], [4], [5]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[3], [4], [5]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[6], [7], [8]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[6], [7], [8]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[11], [12], [13]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[3], [4], [5]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[3], [4], [5]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[3], [4], [5]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[3], [4], [5]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[6], [7], [8]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[3], [4], [5]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[3], [4], [5]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[3], [4], [5]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[3], [4], [5]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[3], [4], [5]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[18], [20], [22]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[26], [8], [27]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[26], [28], [29]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[11], [12], [13]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[30], [31], [32]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[3], [4], [5]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[3], [4], [5]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[34], [9], [35]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[3], [4], [5]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[3], [4], [5]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[6], [7], [8]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[3], [4], [5]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[3], [4], [5]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[3], [4], [5]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[34], [9], [35]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[3], [4], [5]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[34], [36], [37]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[3], [4], [5]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[3], [4], [5]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[3], [4], [5]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[3], [4], [5]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[3], [4], [5]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[3], [4], [5]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[34], [9], [35]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[9], [38], [39]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[3], [4], [5]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[8], [40]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[3], [4], [5]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[3], [4], [5]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[3], [4], [5]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[6], [7], [8]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[9], [38], [39]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[6], [7], [8]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[26], [28], [54]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[9], [58], [59]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[3], [4], [5]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[60]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[3], [4], [5]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[18], [20], [22]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[18], [20], [22]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[18], [20], [22]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[3], [4], [5]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[61], [62], [59]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [8], [63]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[64], [65], [66]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[3], [4], [5]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[3], [4], [5]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[3], [4], [5]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[3], [4], [5]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[67]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[6], [7], [8]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[18], [20], [22]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[3], [4], [5]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[3], [4], [5]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[68]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[9], [38], [39]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[3], [4], [5]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[18], [20], [22]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[47], [51], [52]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[3], [4], [5]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[3], [4], [5]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[6], [7], [8]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[3], [4], [5]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[30], [31], [32]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[70], [71], [72]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[3], [4], [5]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[3], [4], [5]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [8], [51], [52]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[3], [4], [5]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[3], [4], [5]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[3], [4], [5]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[6], [7], [8]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[3], [4], [5]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[3], [4], [5]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[73], [74], [75]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[3], [4], [5]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[18], [20], [22]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[3], [4], [5]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[30], [31], [32]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[3], [4], [5]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[18], [20], [22]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[9], [38], [39]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[18], [20], [22]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[3], [4], [5]
D0711		Garlic	NA	NA	Minor		Inter Info	[77], [78]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[79], [80]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[25]
	Increased risk of bradycardia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[34], [69]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[9], [10]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[9], [10]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[9], [10]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[9], [10]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[9], [10]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[9], [10]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[9], [10]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[55], [56], [57]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[9], [10]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[9], [10]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[9], [10]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[9], [10]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[76], [8]

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