Details of Drug

Drug General Information (ID: D0738)
Drug Name	Granisetron
Drug Type	Small molecule
Drug Synonymous	BRL-43694; Kytril (TN); Granisetron (USAN/INN); 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide Click to Show/Hide
Disease Class	MD90: Nausea/vomiting
Therapeutic Class	Antiemetics
Structure
Structure	3D Structure		2D Structure
Formula	C18H24N4O
InChI	1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+
InChIKey	MFWNKCLOYSRHCJ-AGUYFDCRSA-N
Canonical SMILES	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
External Link
	Pubchem ID	5284566
	CAS Number	109889-09-0
	CHEBI ID	5537
	TTD ID	D0J5KF
	VARIDT ID	DR00439

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM049 Increased risk of atrioventricular block BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Granisetron
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [111], [112], [113], [37]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[212]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[213], [214], [215], [216], [217]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[221], [222], [223], [224], [225], [226], [227], [228], [229], [28], [230], [231], [232], [233], [234], [235], [236], [237]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[238]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[276]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[280]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[284]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[285]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[286]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[287], [288]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[290]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[3], [297]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[298], [299], [300]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[302]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[306]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [307]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[308]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[309]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [3], [310]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[311]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[320]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[151]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[338]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[339], [340]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[346]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[347]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[351]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[368], [369], [343]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[2], [3], [377]
	CYP450 enzyme induction					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [168], [169]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[170]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[281]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[282]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [283]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [291]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[295]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[3], [325]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[330], [331]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3], [332]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [3], [334]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[2], [3], [335], [334]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[337]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [341]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[2], [3], [352], [353]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2], [3], [334]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[370], [371], [372], [373], [374], [375], [376]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[378], [379], [380], [381], [382]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[383]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[378], [379], [380], [381], [382]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2], [4], [301]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2], [4], [301]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[342], [343]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[342], [343]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[342], [343]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[383]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[171], [172], [173]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[289]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[171], [172], [173]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[171], [172], [173]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [2], [3], [319], [37]
	Additive serotonergic effects					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[2], [3], [4]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[2], [3], [4]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1658		Tryptophan	C11H12N2O2	6305	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3], [87], [350]
	Increased risk of prolong QT interval					Drug Num: 149
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [8]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[9], [3], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [28], [29], [30]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [36], [37]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [47]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [6]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [48], [49], [37]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[50]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[51]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[3], [54]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [55]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[56]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [57]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[60], [61], [62], [1], [2], [3], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[83], [1], [2], [3], [84], [85], [86], [87], [88]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[9], [3], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [89], [37]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[92]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[93]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [94], [37]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[2], [6], [7]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [95]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[96]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [97], [37]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [98]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[99]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [109]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [48], [110], [37]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[114], [115], [1], [2], [3], [116], [117]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[61], [1], [2], [3], [118], [119], [65], [67], [69], [120], [70], [71], [121], [73], [74], [75], [76], [122], [80], [123], [124]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2], [3], [125]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [126]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[61], [1], [2], [3], [127], [128], [123]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [129], [130], [131], [132], [133], [134], [37]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [135]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [37]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [146]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[60], [61], [62], [1], [2], [3], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3], [31], [32], [33], [4], [5], [6], [34], [7], [35]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [38], [39], [40], [41], [42], [43], [44], [45], [46], [37]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [147], [48], [148], [149], [150], [37]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [151]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [152], [4], [5], [6], [7]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [48], [153], [37]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1], [2], [3], [112], [37]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[211]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[67], [167], [37]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[67], [167], [37]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [269], [270], [271], [272], [273], [274]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [2], [3], [275], [37]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [113]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[292]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[2], [3], [293]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [2], [3], [294]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [296]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[61], [69], [70], [75], [303]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[304]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[305]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[61], [1], [2], [3], [65], [66], [67], [312], [313], [70], [71], [314], [72], [315], [73], [74], [75], [76], [316], [317], [318], [80], [123]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[3]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[61], [1], [2], [3], [65], [66], [67], [312], [313], [70], [71], [314], [72], [315], [73], [74], [75], [76], [316], [317], [318], [80], [123]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[61], [1], [2], [3], [65], [66], [67], [312], [313], [70], [71], [314], [72], [315], [73], [74], [75], [76], [316], [317], [318], [80], [123]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [321]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[324]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [2], [3], [48], [326], [327], [328], [329], [37]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1], [2], [3], [333]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [2], [3], [336]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1], [2], [3], [344], [37]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[348], [349]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[3], [154], [155], [156], [157], [158], [159], [160]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[354], [355]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[356], [357], [358], [359], [360], [361], [362], [363], [364], [365]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[366], [367]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[1], [2], [3], [48], [67], [167], [37]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [384], [385], [386]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [387], [388], [389], [390]
	Increased risk of ventricular arrhythmias					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[52], [53]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [58], [59]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [90], [91]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[100]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[1], [161], [2], [3], [162], [163], [164], [28], [165], [166]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [218], [219], [220]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [218], [219], [220]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [279]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[252], [262], [265]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[252], [262], [265]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [322], [323]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [322], [323]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [279]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [218], [219], [220]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[252], [262], [265]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [322], [323]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [345]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[252], [262], [265]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [277], [278], [279]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[252], [262], [265]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [218], [219], [220]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
5	Product Information. Aloxi (palonosetron). MGI Pharma Inc, Minnetonka, MN.
6	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
7	Product Information. Sancuso (granisetron). ProStrakan Group, Bedminster, NJ.
8	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
9	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
10	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
11	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
12	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
13	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
14	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
15	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
16	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
17	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
18	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
19	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
20	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
21	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
22	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
23	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
24	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
25	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
26	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
27	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
28	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
29	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
30	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
31	Koriech OM "Fluoxetine treatment comprises the antiemetic efficacy of ondansetron in cancer patients." Clin Oncol (R Coll Radiol) 7 (1995): 371-2. [PMID: 8590698]
32	Oren DA "Dysphoria after treatment with ondansetron." Am J Psychiatry 152 (1995): 1101. [PMID: 7793456]
33	Palmer JL "Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine?." J Psychopharmacol 14 (2000): 186. [PMID: 10890314]
34	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
35	Product Information. Zofran (ondansetron). Cerenex Pharmaceuticals, Research Triangle Pk, NC.
36	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
37	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
38	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
39	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
40	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
41	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
42	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
43	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
44	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
45	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
46	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
47	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
48	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
49	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
50	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
51	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
52	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
53	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
54	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
55	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
56	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
57	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
58	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
59	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
60	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
61	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
62	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
63	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
64	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
65	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
66	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
67	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
68	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
69	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
70	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
71	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
72	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
73	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
74	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
75	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
76	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
77	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
78	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
79	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
80	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
81	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
82	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
83	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
84	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
85	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
86	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
87	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
88	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
89	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
90	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
91	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
92	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
93	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
94	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
95	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
96	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
97	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
98	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
99	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
100	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
101	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
102	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
103	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
104	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
105	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
106	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
107	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
108	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
109	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
110	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
111	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
112	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
113	Abbas R, Hug BA, Leister C, Sonnichsen D "A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects." Int J Cancer 131 (2012): Epub. [PMID: 22065400]
114	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
115	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
116	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
117	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
118	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
119	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
120	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
121	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
122	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
123	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
124	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
125	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
126	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
127	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
128	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
129	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
130	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
131	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
132	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
133	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
134	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
135	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
136	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
137	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
138	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
139	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
140	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
141	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
142	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
143	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
144	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
145	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
146	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
147	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
148	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
149	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
150	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
151	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
152	DeWitte JL, Schoenmaekers B, Sessler DI, DeLoof T "The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron." Anesth Analg 92 (2001): 1319-21. [PMID: 11323369]
153	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
154	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
155	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
156	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
157	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
158	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
159	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
160	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
161	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
162	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
163	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
164	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
165	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
166	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
167	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
168	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
169	Wakelee HA, Takimoto CH, Lopez-Anaya A, et al. "The effect of bexarotene on atorvastatin pharmacokinetics: results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer." Cancer Chemother Pharmacol 69 (2012): 563-71. [PMID: 22057855]
170	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
171	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
172	Mittino D, Mula M, Monaco F "Serotonin syndrome associated with tramadol-sertraline coadministration." Clin Neuropharmacol 27 (2004): 150-1. [PMID: 15190240]
173	Das PK, Warkentin DI, Hewko R, Forrest DL "Serotonin syndrome after concomitant treatment with linezolid and meperidine." Clin Infect Dis 46 (2008): 264-5. [PMID: 18171260]
174	Gillman PK "Possible serotonin syndrome with moclobemide and pethidine." Med J Aust 162 (1995): 554. [PMID: 7776924]
175	Shakoor M, Ayub S, Ahad A, Ayub Z "Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor." Am J Case Rep 15 (2014): 562-4. [PMID: 25540831]
176	Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. [PMID: 8909274]
177	Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7. [PMID: 9034418]
178	Dougherty JA, Young H, Shafi T "Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine." Ann Pharmacother 36 (2002): 1647-1648. [PMID: 12243617]
179	US Food and Drug Administration (FDA) "FDA Drug Safety Communication: FDA warns about several safety issues with opioid pain medicines requires label changes.".
180	Kesavan S, Sobala GM "Serotonin syndrome with fluoxetine plus tramadol." J R Soc Med 92 (1999): 474-5. [PMID: 10645303]
181	Lange-Asschenfeldt C, Weigmann H, Hiemke C, Mann K "Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology." J Clin Psychopharmacol 22 (2002): 440-1. [PMID: 12172351]
182	Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7. [PMID: 8109782]
183	Gonzalez-Pinto A, Imaz H, De Heredia JL, Gutierrez M, Mico JA "Mania and tramadol-fluoxetine combination." Am J Psychiatry 158 (2001): 964-5. [PMID: 11384912]
184	Hansen TE, Dieter K, Keepers GA "Interaction of fluoxetine and pentazocine." Am J Psychiatry 147 (1990): 949-50. [PMID: 2356884]
185	Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2. [PMID: 9248876]
186	Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202. [PMID: 17381671]
187	Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6. [PMID: 1464133]
188	Venlafaxine + tramadol: serotonin syndrome. Prescrire Int 13 (2004): 57. [PMID: 15148976]
189	Rang ST, Field J, Irving C "Serotonin toxicity caused by an interaction between fentanyl and paroxetine." Can J Anaesth 55 (2008): 521-5. [PMID: 18676387]
190	Lantz MS, Buchalter EN, Giambanco V "Serotonin syndrome following the administration of tramadol with paroxetine." Int J Geriatr Psychiatry 13 (1998): 343-5. [PMID: 9658268]
191	Tissot TA "Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use." Anesthesiology 98 (2003): 1511-1512. [PMID: 12766667]
192	Meyer D, Halfin V "Toxicity secondary to meperidine in patients on monoamine oxidase inhibitors: a case report and critical review." J Clin Psychopharmacol 1 (1981): 319-21. [PMID: 7334144]
193	Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763. [PMID: 9330840]
194	Gnanadesigan N, Espinoza RT, Smith R, Israel M, Reuben DB "Interaction of serotonergic antidepressants and opioid analgesics: Is serotonin syndrome going undetected?" J Am Med Dir Assoc 6 (2005): 265-9. [PMID: 16005413]
195	Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):. [PMID: 16051647]
196	Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5. [PMID: 9861909]
197	Roy S, Fortier LP "Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine." Can J Anaesth 50 (2003): 32-5. [PMID: 12514147]
198	Abadie D, Rousseau V, Logerot S, Cottin J, Montastruc JL, Montastruc F "Serotonin Syndrome: Analysis of Cases Registered in the French Pharmacovigilance Database." J Clin Psychopharmacol (2015):. [PMID: 26082973]
199	Houlihan DJ "Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine." Ann Pharmacother 38 (2004): 411-3. [PMID: 14970364]
200	Hillman AD, Witenko CJ, Sultan SM, Gala G "Serotonin syndrome caused by fentanyl and methadone in a burn injury." Pharmacotherapy 35 (2015): 112-7. [PMID: 25615513]
201	Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13. [PMID: 2035713]
202	Rosebraugh CJ, floxkhart DA, Yasuda SU, Woosley RL "Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient." J Clin Pharmacol 41 (2001): 224-7. [PMID: 11210406]
203	Davis JJ, Buck NS, Swenson JD, Johnson KB, Greis PE "Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil." J Clin Anesth 25 (2013): 52-4. [PMID: 23391344]
204	Guo SL, Wu TJ, Liu CC, Ng CC, Chien CC, Sun HL "Meperidine-induced serotonin syndrome in a susceptible patient." Br J Anaesth (2009):. [PMID: 19556270]
205	Mateo-Carrasco H, Munoz-Aguilera EM, Garcia-Torrecillas JM, Abu Al-Robb H "Serotonin Syndrome Probably Triggered by a Morphine-Phenelzine Interaction." Pharmacotherapy (2015):. [PMID: 25903219]
206	Kitson R, Carr B "Tramadol and severe serotonin syndrome." Anaesthesia 60 (2005): 934-5. [PMID: 16115263]
207	Hunter B, Kleinert MM, Osatnik J, Soria E "Serotonergic syndrome and abnormal ocular movements: worsening of rigidity by remifentanil?" Anesth Analg 102 (2006): 1589. [PMID: 16632855]
208	Zornberg GL, Bodkin JA, Cohen BM "Severe adverse interaction between pethidine and selegiline." Lancet 337 (1991): 246. [PMID: 1670882]
209	Mahlberg R, Kunz D, Sasse J, Kirchheiner J "Serotonin syndrome with tramadol and citalopram." Am J Psychiatry 161 (2004): 1129. [PMID: 15169709]
210	Larson KJ, Wittwer ED, Nicholson WT, Weingarten TN, Price DL, Sprung J "Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy." J Clin Anesth 27 (2015): 247-51. [PMID: 25499271]
211	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
212	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
213	Abernethy DR, Egan JM, Dickinson TH, Carrum G "Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans." J Pharmacol Exp Ther 244 (1988): 994-9. [PMID: 3252045]
214	Renton KW "Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil." Biochem Pharmacol 34 (1985): 2549-53. [PMID: 4015695]
215	Sakai H, Kobayashi S, Hamada K, et al "The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates." Br J Clin Pharmacol 31 (1991): 353-5. [PMID: 2054276]
216	Sutton D, Butler AM, Nadin L, Murray M "Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites." J Pharmacol Exp Ther 282 (1997): 294-300. [PMID: 9223567]
217	Varis T, Backman JT, Kivisto KT, Neuvonen PJ "Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone." Clin Pharmacol Ther 67 (2000): 215-21. [PMID: 10741623]
218	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
219	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
220	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
221	Assan R, Fredj G, Larger E, Feutren G, Bismuth H "FK 506/fluconazole interaction enhances FK 506 nephrotoxicity." Diabete Metab 20 (1994): 49-52. [PMID: 7520007]
222	Baciewicz AM, Baciewicz FA, Jr "Ketoconazole and fluconazole drug interactions." Arch Intern Med 153 (1993): 1970-6. [PMID: 8357281]
223	Barbara JA, Clarkson AR, LaBrooy J, et al "Candida albicans arthritis in a renal allograft recipient with an interaction between cyclosporin and fluconazole." Nephrol Dial Transplant 8 (1993): 263-6. [PMID: 8385297]
224	Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75. [PMID: 8879971]
225	Canafax DM, Graves NM, Hilligoss DM, et al "Interaction between cyclosporine and fluconazole in renal allograft recipients." Transplantation 51 (1991): 1014-8. [PMID: 2031258]
226	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
227	Finch CK, Green CA, Self TH "Fluconazole-carbamazepine interaction." South Med J 95 (2002): 1099-100. [PMID: 12356123]
228	Hilbert J, Messig M, Kuye O, Friedman H "Evaluation of interaction between fluconazole and an oral contraceptive in healthy women." Obstet Gynecol 98 (2001): 218-23. [PMID: 11506836]
229	Lopez-Gil JA "Fluconazole-cyclosporin interaction: a dose-dependent effect?" Ann Pharmacother 27 (1993): 427-30. [PMID: 8477116]
230	Nair DR, Morris HH "Potential fluconazole-induced carbamazepine toxicity." Ann Pharmacother 33 (1999): 790-2. [PMID: 10466905]
231	Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72. [PMID: 8610430]
232	Product Information. Diflucan (fluconazole). Roerig Division, New York, NY.
233	Sinofsky FE, Pasquale SA "The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives." Am J Obstet Gynecol 178 (1998): 300-4. [PMID: 9500490]
234	Sugar AM, Saunders C, Idelson BA, Bernard DB "Interaction of fluconazole and cyclosporine." Ann Intern Med 110 (1989): 844. [PMID: 2540690]
235	Torregrosa V, De la Torre M, Campistol JM, et al "Interaction of fluconazole with ciclosporin A." Nephron 60 (1992): 125-6. [PMID: 1738408]
236	Tsouli S, Maranis S, Kyritsis AP "Fluconazole-carbamazepine interaction in a patient with bipolar disorder." Psychiatry Clin Neurosci 65 (2011): 112. [PMID: 21265947]
237	Ulivelli M, Rubegni P, Nuti D, Bartalini S, Giannini F, Rossi S "Clinical evidence of fluconazole-induced carbamazepine toxicity." J Neurol 251 (2004): 622-3. [PMID: 15164201]
238	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
239	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
240	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
241	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
242	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
243	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
244	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
245	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
246	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
247	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
248	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
249	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
250	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
251	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
252	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
253	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
254	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
255	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
256	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
257	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
258	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
259	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
260	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
261	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
262	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
263	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
264	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
265	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
266	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
267	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
268	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
269	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
270	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
271	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
272	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
273	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
274	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
275	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
276	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
277	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
278	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
279	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
280	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
281	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
282	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
283	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
284	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
285	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
286	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
287	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
288	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
289	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
290	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
291	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
292	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
293	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
294	Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
295	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
296	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
297	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
298	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
299	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
300	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
301	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
302	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
303	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
304	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
305	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
306	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
307	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
308	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
309	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
310	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
311	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
312	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones." Br Med J 322 (2001): 46-7. [PMID: 11141163]
313	Kahn JB "Latest industry information on the safety profile of levofloxacin in the US." Chemotherapy 47 Suppl 3 (2001): 32-7. [PMID: 11549787]
314	Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B "Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant "clinical" event?" South Med J 99 (2006): 52-6. [PMID: 16466123]
315	Nykamp DL, Blackmon CL, Schmidt PE, Roberson AG "QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine." Ann Pharmacother 39 (2005): 543-6. [PMID: 15687478]
316	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
317	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
318	Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
319	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
320	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
321	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
322	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
323	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
324	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
325	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
326	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
327	Sala M, Vicentini A, Brambilla P, et al. "QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy." Ann Gen Psychiatry 4 (2005): 1. [PMID: 15845138]
328	Vieweg WV "New generation antipsychotic drugs and QTc interval prolongation." Prim Care Companion J Clin Psychiatry 5 (2003): 205-15. [PMID: 15213787]
329	Vieweg WV, Schneider RK, Wood MA "Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine." Acta Psychiatr Scand 112 (2005): 318-22. [PMID: 16156840]
330	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
331	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
332	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
333	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
334	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
335	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
336	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
337	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
338	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
339	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
340	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
341	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
342	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
343	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
344	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
345	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
346	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
347	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
348	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
349	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
350	Canadian Pharmacists Association "e-CPS."
351	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
352	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
353	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
354	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
355	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
356	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
357	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
358	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
359	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
360	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
361	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
362	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
363	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
364	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
365	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
366	European Medicines Agency "CHMP Assessment Report for Latixa. International nonproprietary name: ranolazine.".
367	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
368	Olkkola KT, Palkama VJ, Neuvonen PJ "Ritonavir's role in reducing fentanyl clearance and prolonging its half-life." Anesthesiology 91 (1999): 681-5. [PMID: 10485779]
369	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
370	Burgess SJ, Singer GG, Brennan DC "Effect of troglitazone on cyclosporine whole blood levels." Transplantation 66 (1998): 272. [PMID: 9701278]
371	Frantz RP, Nguyen TT "Rezulin (troglitazone) greatly increases cyclosporine metabolism." J Heart Lung Transplant 17 (1998): 1037-8. [PMID: 9811416]
372	Fraser CG, Fierro L "Comment: troglitazone." Ann Pharmacother 32 (1998): 1111-2. [PMID: 9793612]
373	Kaplan B, Friedman G, Jacobs M, Viscuso R, Lyman N, DeFranco P, Bonomini L, Mulgaonkar SP "Potential interaction of troglitazone and cyclosporine." Transplantation 65 (1998): 1399-400. [PMID: 9625027]
374	Park MH, Pelegrin D, Haug MT, Young JB "Troglitazone, a new antidiabetic agent, decreases cyclosporine level." J Heart Lung Transplant 17 (1998): 1139-40. [PMID: 9855455]
375	Product Information. Rezulin (troglitazone). Parke-Davis, Morris Plains, NJ.
376	Terra SG, Washam JB, May DB "Comment: troglitazone drug interactions." Ann Pharmacother 32 (1998): 1111. [PMID: 9793611]
377	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
378	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
379	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
380	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
381	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
382	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
383	Product Information. Kytril (granisetron). SmithKline Beecham, Philadelphia, PA.
384	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
385	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
386	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
387	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
388	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
389	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
390	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

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