Details of Drug

Drug General Information (ID: D0682)
Drug Name	Flutamide
Drug Type	Small molecule
Drug Synonymous	Apimid; ApoFlutamide; Cebatrol; Chimax; Cytamid; Drogenil; Eulexin; Eulexine; Fluken; Flulem; Flumid; FlutaGRY; Flutacell; Flutamida; Flutamidum; Flutamin; Flutandrona; Flutaplex; Flutexin; Fugerel; METHOXYCHLOR; NFBA; Niftholide; Niftolid; Niftolide; NovoFlutamide; Odyne; Oncosal; Prostacur; Prostandril; Prostica; Prostogenat; Testotard; Alphapharm Brand of Flutamide; Apo Flutamide; Apogepha Brand of Flutamide; Apotex Brand of Flutamide; Azupharma Brand of Flutamide; Cell pharm Brand of Flutamide; Chephasaar Brand of Flutamide; Chiron Brand of Flutamide; Ciclum Brand of Flutamide; Esparma Brand of Flutamide; Essex Brand of Flutamide; Fluta GRY; Fluta cell; Gry Brand of Flutamide; Hexal Brand of Flutamide; InibsaBrand of Flutamide; Ipsen Brand of Flutamide; Juta Brand of Flutamide; Kendrick Brand of Flutamide; Lemery Brand of Flutamide; Novo Flutamide; Novopharm Brand of Flutamide; PMS Flutamide; Pharmascience Brand of Flutamide; Prasfarma Brand of Flutamide; Q Pharm Brand of Flutamide; Schering Brand of Flutamide; Schering Plough Brand of Flutamide; TAD Brand of Flutamide; Tedec Meiji Brand of Flutamide; F 9397; F0663; Fluta 1A Pharma; Flutamide USP25; SCH13521; Sch 13521; Apo-Flutamide; Cebatrol, veterinary; Eulexin (TN); Fluta-GRY; Fluta-cell; Flutamida [INN-Spanish]; Flutamide(pubertal study); Flutamidum [INN-Latin]; NK-601; Novo-Flutamide; PMS-Flutamide; PUBERTAL FLUTAMIDE STUDY (PUBERTAL STUDIES OF VINCLOZOLIN; Q-Pharm Brand of Flutamide; Sch-13521; Schering-Plough Brand of Flutamide; Flutamide [USAN:BAN:INN]; Ham's F-12 medium; Eulexin, Flutamin, Drogenil,Flutamide; Flutamide (JAN/USP/INN); Alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide; M-propionotoluidide,alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro; M-Propionotoluidide, alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-(8CI); 1A Brand of Flutamide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide; 4'-Nitro-3'-(trifluoromethyl)isobutyranilide; 4'-Nitro-3'-trifluoromethylisobutyramilide; 4'-Nitro-3'-trifluoromethylisobutyranilide; 4-Nitro-3-(trifluoromethyl)isobutyranilide; Flutamide (AR inhibitor) Click to Show/Hide
Disease Class	2C82: Prostate cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C11H11F3N2O3
InChI	1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChIKey	MKXKFYHWDHIYRV-UHFFFAOYSA-N
Canonical SMILES	CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
External Link
	Pubchem ID	3397
	CAS Number	13311-84-7
	CHEBI ID	5132
	TTD ID	D0Y0SW
	INTEDE ID	DR0733
	VARIDT ID	DR00846

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM071 Increased risk of methemoglobinemia BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Flutamide
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[161]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[210]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[212]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[213]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[217]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[223]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[2], [3], [251]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [3], [6]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[3], [100], [261], [262], [103]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[224]
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[158], [159], [160]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[160]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[160]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [74], [75]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[77]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[82]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[97]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [74], [75]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[146], [147], [148], [2], [3], [149], [150], [151], [152], [153], [154], [155], [156]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[146], [147], [148], [2], [3], [149], [150], [151], [152], [153], [154], [155], [156]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[208]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [209]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[211]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[214], [215]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[218]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [221]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[222]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[225], [226], [227], [228]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [3], [245], [246], [247]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [249]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[225], [226], [227], [228]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[225], [226], [227], [228]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[146], [147], [148], [2], [3], [149], [150], [151], [152], [153], [154], [155], [156]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[252], [253]
	Increased risk of methemoglobinemia					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[83], [84], [85]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[99], [2], [3], [100], [101], [102], [103]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[1], [2], [103]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[3], [100], [204]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[3], [100], [204]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[3], [100], [204]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[3], [100], [204]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[3], [100], [204]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[3], [100], [204]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[3], [100], [204]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[3], [100], [204]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[233], [3], [234]
	Increased risk of prolong QT interval					Drug Num: 161
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [5], [6]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [6]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [16]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [17], [18], [6]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[19]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[22]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [6]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[3], [23]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [24], [25], [26]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [27]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [28]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [29], [2], [3], [30], [31], [6]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[34], [35], [36], [1], [2], [3], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[57], [1], [2], [3], [58], [59], [60], [61], [62]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [63], [64], [65], [66], [67], [68], [6]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [69], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[72]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[73]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [76], [6]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [78]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[79]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [80], [6]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [81]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[86]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[88], [89], [90], [91], [92], [93], [94], [95]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [96]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [17], [98], [6]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [6]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [6]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [17], [41], [104], [105], [6]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[106], [107], [1], [2], [3], [108], [109]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[3], [110]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[35], [1], [2], [3], [112], [113], [39], [41], [43], [114], [44], [45], [115], [47], [48], [49], [50], [116], [54], [117], [118]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [119], [17], [120], [121], [122], [6]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [123]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [124]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[35], [1], [2], [3], [125], [126], [117]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [127]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [6]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [6]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [17], [138], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[3], [144], [145]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [198], [199], [200], [201], [202], [203]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[3], [144], [145]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[3], [144], [145]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[3], [144], [145]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[3], [144], [145]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [216]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[3], [144], [145]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[219], [220]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[229], [230]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[235], [236], [237], [238], [239], [240], [241], [242], [243], [244]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[2], [3], [250]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[3], [139], [140], [141], [142], [143], [144], [145]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [254], [255], [256]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [257], [258], [259], [260]
	Increased risk of ventricular arrhythmias					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[20], [21]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [32], [33]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [70], [71]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[87]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [111]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[1], [162], [2], [3], [163], [164], [165], [24], [166], [167]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [207]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[181], [191], [194]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[181], [191], [194]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[181], [191], [194]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [205], [206], [207]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [231], [232]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [231], [232]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [207]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[181], [191], [194]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [231], [232]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [248]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[181], [191], [194]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1756		Capromab pendetide	C10H15N5O11P2	135509147	Moderate		Inter Info	[157]

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
5	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
6	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
7	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
8	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
9	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
10	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
11	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
12	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
13	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
14	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
15	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
16	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
17	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
18	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
19	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
20	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
21	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
22	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
23	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
24	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
25	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
26	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
27	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
28	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
29	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
30	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
31	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
32	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
33	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
34	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
35	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
36	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
37	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
38	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
39	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
40	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
41	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
42	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
43	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
44	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
45	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
46	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
47	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
48	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
49	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
50	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
51	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
52	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
53	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
54	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
55	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
56	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
57	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
58	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
59	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
60	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
61	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
62	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
63	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
64	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
65	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
66	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
67	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
68	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
69	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
70	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
71	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
72	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
73	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
74	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
75	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
76	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
77	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
78	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
79	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
80	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
81	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
82	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
83	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
84	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
85	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
86	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
87	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
88	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
89	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
90	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
91	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
92	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
93	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
94	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
95	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
96	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
97	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
98	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
99	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
100	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
101	Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
102	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
103	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
104	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
105	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
106	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
107	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
108	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
109	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
110	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
111	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
112	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
113	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
114	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
115	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
116	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
117	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
118	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
119	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
120	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
121	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
122	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
123	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
124	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
125	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
126	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
127	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
128	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
129	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
130	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
131	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
132	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
133	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
134	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
135	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
136	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
137	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
138	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
139	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
140	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
141	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
142	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
143	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
144	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
145	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
146	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
147	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
148	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
149	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
150	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
151	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
152	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
153	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
154	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
155	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
156	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
157	Product Information. ProstaScint (capromab pendetide). Aytu BioScience, Inc, Englewood, CO.
158	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
159	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
160	Product Information. Eulexin (flutamide). Schering Laboratories, Kenilworth, NJ.
161	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
162	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
163	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
164	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
165	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
166	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
167	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
168	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
169	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
170	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
171	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
172	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
173	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
174	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
175	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
176	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
177	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
178	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
179	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
180	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
181	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
182	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
183	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
184	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
185	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
186	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
187	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
188	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
189	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
190	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
191	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
192	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
193	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
194	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
195	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
196	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
197	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
198	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
199	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
200	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
201	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
202	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
203	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
204	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
205	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
206	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
207	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
208	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
209	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
210	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
211	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
212	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
213	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
214	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
215	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
216	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
217	Product Information. Givlaari (givosiran). Alnylam Pharmaceuticals, Cambridge, MA.
218	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
219	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
220	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
221	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
222	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
223	Product Information. Ocaliva (obeticholic acid). Intercept Pharmaceuticals, Inc., New York, NY.
224	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
225	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
226	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
227	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
228	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
229	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
230	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
231	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
232	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
233	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
234	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
235	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
236	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
237	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
238	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
239	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
240	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
241	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
242	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
243	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
244	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
245	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
246	Gilead Sciences, Inc "About Remdesivir.".
247	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
248	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
249	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
250	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
251	Shet MS, McPhaul M, Fisher CW, Stallings NR, Estabrook RW "Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2." Drug Metab Dispos 25 (1997): 1298-303. [PMID: 9351907]
252	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
253	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
254	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
255	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
256	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
257	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
258	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
259	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
260	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]
261	Product Information. Marcaine HCl (bupivacaine). Hospira Inc, Lake Forest, IL.
262	Product Information. Zynrelef (bupivacaine-meloxicam). Heron Therapeutics, Redwood City, CA.

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