Details of Drug

Drug General Information (ID: D0595)
Drug Name	Erlotinib
Drug Type	Small molecule
Drug Synonymous	Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline Click to Show/Hide
Disease Class	2C25: Lung cancer; 2B90: Colon cancer; 2C10: Pancreatic cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C22H23N3O4
InChI	1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
InChIKey	AAKJLRGGTJKAMG-UHFFFAOYSA-N
Canonical SMILES	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC
External Link
	Pubchem ID	176870
	CAS Number	183321-74-6
	CHEBI ID	114785
	TTD ID	D07POC
	VARIDT ID	DR00558

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM005 Altered gastric pH BM010 Transporter inhibition BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM043 Additive immunosuppressive effects BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Erlotinib
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Major		Inter Info	[3], [4], [5], [6]
D0603		Esomeprazole	C17H19N3O3S	9568614	Major		Inter Info	[3], [4], [5], [6]
D1373		Rabeprazole	C18H21N3O3S	5029	Major		Inter Info	[3], [4], [5], [6]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Major		Inter Info	[3], [4], [5], [6]
D1179		Omeprazole	C17H19N3O3S	4594	Major		Inter Info	[3], [4], [5], [6]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Major		Inter Info	[3], [4], [5], [6]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[3], [4], [5], [6]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[3], [4], [5], [6]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[3], [4], [5], [6]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[3], [4], [5], [6]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[3], [4], [5], [6]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[3], [4], [5], [6]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3], [4], [5], [6]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[3], [4], [5], [6]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[3], [4], [5], [6]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[3], [4], [5], [6]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[3], [4], [5]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[3], [4], [5], [6]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[3], [4], [5], [6]
D1489		Sodium zirconium cyclosilicate	H6Na2O9Si3Zr+2	91799284	Moderate		Inter Info	[4], [82]
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[4], [29], [30]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [34], [35]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[37]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[4], [39]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[4], [44]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[45]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[48]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[4], [49]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[4], [50]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[56]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[57]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[4]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[80]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[3], [4], [84], [85]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[25], [6], [26]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[6], [26]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[6], [26]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[28]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[6]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[13], [6]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[13], [6]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[13], [6]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[13], [6]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[6]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[13], [6]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[13], [6]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[13], [6]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[40]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[41]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[13], [6]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[42]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[13], [6]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[4], [52]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[6]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[13], [6]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[53]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[13], [6]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[54]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [4], [55]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[58], [59], [60]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[62]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[13], [6]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[13], [6]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[13], [6]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[68]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[13], [6]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[7], [3], [4], [79]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[13], [6]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[13], [6]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[13], [6]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[13], [6]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[13], [6]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[13], [6]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[6]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[13], [6]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[13], [6]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[6]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[6]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[13], [6]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[13], [6]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[13], [6]
	CYP450 enzyme induction					Drug Num: 50
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[13], [6]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[13], [6]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[13], [6]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[13], [6]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[13], [6]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[13], [6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[13], [6]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[13], [6]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[13], [6]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[13], [6]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[13], [6]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[13], [6]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[3], [43]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[13], [6]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[13], [6]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[13], [6]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[13], [6]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[13], [6]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[13], [6]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[13], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[13], [6]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[13], [61], [6]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[13], [6]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[13], [61], [6]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[13], [61], [6]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[13], [6]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[13], [6]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[13], [6]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[13], [6]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[13], [6]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[13], [6]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[13], [6]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[13], [61], [6]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[13], [6]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[13], [61], [6]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[13], [6]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[13], [6]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[13], [6]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[13], [6]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[4], [83]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[13], [6]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[13], [6]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [6]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[13], [6]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[13], [6]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[13], [6]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[13], [61], [6]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[13], [6]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[90], [91], [92], [93], [94]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[90], [91], [92], [93], [94]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[3], [46], [47]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[3], [46], [47]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[69]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[7], [8], [9]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[10]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[11]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[12]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[7], [8], [9]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[14], [15], [16], [3], [4], [17], [18], [19], [20], [21], [22], [23], [24]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[3], [4], [27]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[14], [15], [16], [3], [4], [17], [18], [19], [20], [21], [22], [23], [24]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[32]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[33]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[14], [15], [16], [3], [4], [17], [18], [19], [20], [21], [22], [23], [24]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [36]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[38]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[51]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[4], [63]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[67]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[70], [71], [72], [73]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[3], [4], [76], [77], [78]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [86]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[70], [71], [72], [73]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[70], [71], [72], [73]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[87], [88]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[3], [4], [31]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[3], [64], [1], [65], [66]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[3], [4], [31]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[74], [4], [75]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[4], [64], [1], [89]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[81]

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3	Cerner Multum, Inc. "Australian Product Information.".
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6	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
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8	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
9	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
10	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
11	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
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22	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
23	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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28	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
29	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
30	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
32	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
33	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
34	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
35	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
36	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
37	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
38	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
39	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
40	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
41	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
42	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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45	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
46	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
47	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
48	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
49	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
50	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
51	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
52	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
53	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
54	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
55	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
56	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
57	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
58	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
59	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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62	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
63	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
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65	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
66	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
67	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
68	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
69	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
70	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
71	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
72	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
73	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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80	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
81	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
82	Product Information. Lokelma (sodium zirconium cyclosilicate). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
83	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
84	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
85	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
86	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
87	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
88	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
89	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
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92	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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