Details of Drug

Drug General Information (ID: D0588)
Drug Name	Eptifibatide
Drug Type	Small molecule
Drug Synonymous	Integrelin; Integrilin; Intrifiban; HS-2011; Integrilin (TN); SB-1; Sch-60936; N(6)-amidino-N(2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; N(sup 6)-Amidino-N(sup 2)-(3-mercaptopropionyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1-6)-disulfide; S(1),S(6)-cyclo[N(6)-carbamimidoyl-N(2)-(3-sulfanylpropanoyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide]; L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic (1-6)-disulfide; L-Cysteinamide,N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-propyl-,cyclic (1-6)-disulfide; [(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid; 2-[(3S,6S,12S,20R,23S)-20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid; 2-[20-carbamoyl-12-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,22-hexaoxo-17,18-dithia-1,4,7,10,13,21-hexazabicyclo[21.3.0]hexacosan-6-yl]acetic acid Click to Show/Hide
Disease Class	BA40: Angina pectoris
Therapeutic Class	Anticoagulants
Structure
Structure	3D Structure		2D Structure
Formula	C35H49N11O9S2
InChI	1S/C35H49N11O9S2/c36-30(51)25-18-57-56-13-10-27(47)42-22(8-3-4-11-39-35(37)38)31(52)41-17-28(48)43-23(15-29(49)50)32(53)44-24(14-19-16-40-21-7-2-1-6-20(19)21)34(55)46-12-5-9-26(46)33(54)45-25/h1-2,6-7,16,22-26,40H,3-5,8-15,17-18H2,(H2,36,51)(H,41,52)(H,42,47)(H,43,48)(H,44,53)(H,45,54)(H,49,50)(H4,37,38,39)/t22-,23-,24-,25-,26-/m0/s1
InChIKey	CZKPOZZJODAYPZ-LROMGURASA-N
Canonical SMILES	C1CC2C(=O)NC(CSSCCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N2C1)CC3=CNC4=CC=CC=C43)CC(=O)O)CCCCN=C(N)N)C(=O)N
External Link
	Pubchem ID	448812
	CAS Number	188627-80-7
	CHEBI ID	291902
	TTD ID	D09ZIO

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM050 Increased risk of bleeding BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Eptifibatide
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 130
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2], [4]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1], [2], [4]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[5]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[6]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[7], [3]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[7], [3]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[2], [8]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[16], [17], [18]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [19]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[20]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[21]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[2], [22]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [23]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[24], [7], [3], [25]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D0415		Danaparoid	NA	NA	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[26]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[27], [28]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[2], [29]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[30], [31]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[32], [7], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[24], [7], [3], [25]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[33]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[34], [35], [36], [37], [38], [7], [3], [39]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[40]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[41], [42], [2], [43]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [27], [44]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[27], [45]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [46]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[47]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[24], [7], [3], [25]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[48]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [49], [50]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[51]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1], [2], [4]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[24], [7], [3], [25]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[52]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3]
D1613		Tositumomab	NA	NA	Major		Inter Info	[53], [54]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[53], [54]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1], [2], [55]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[56]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[7], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[27]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[16], [17], [18]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2], [4]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1], [2], [4]
D1669		Urokinase	NA	NA	Major		Inter Info	[1], [2], [4]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[17]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[57]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[36], [24], [7]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[36], [24], [7], [3]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[58], [59], [60]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[61]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[36], [24], [7], [3]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[62], [63], [64]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[27], [103]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[7], [3]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[58], [59], [60]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[58], [59], [60]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[36], [24], [7], [3]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[104], [105], [106]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[7], [3]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[7], [3]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[7], [3]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[58], [59], [60]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0711		Garlic	NA	NA	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[112], [122], [123], [116], [119]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[124], [125], [126], [127], [109], [128], [129], [110], [112], [113], [130], [122], [131], [116], [132], [133], [134], [119], [135]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[136], [110], [112], [137], [113], [138], [116], [119], [139]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[140]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[7], [3]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[2], [141], [142]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[104], [105], [106]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[7], [3]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[7], [3]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[7], [3]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[58], [59], [60]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[7], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[7], [3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[7], [3]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[7], [3]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[7], [3]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[58], [59], [60]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[143]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [144]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[2], [141], [142]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[7], [3]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[27], [145]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[146], [147]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[36], [24], [7]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[7], [3]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[7], [3]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[61]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[36], [24], [7]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[36], [24], [7], [3]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[148], [149], [150]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[7], [3]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[58], [59], [60]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2], [151]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[7], [3]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[104], [105], [106]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[61]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[148], [154], [2], [155], [156], [157], [158], [112], [159], [160], [161], [162], [163], [164], [165], [149], [166], [167], [150], [168]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[65], [66], [67], [68], [1], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102]
D0253		Capsicum	NA	NA	Minor		Inter Info	[112]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[112], [169], [116]
D0368		Clove	NA	NA	Minor		Inter Info	[112], [170], [171], [172]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[173], [112], [174]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[152], [153]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. ReoPro (abciximab). Lilly, Eli and Company, Indianapolis, IN.
4	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
5	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
6	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
7	Product Information. Integrilin (eptifibatide). Schering Laboratories, Kenilworth, NJ.
8	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
9	Price AJ, Frcpath DO "Is there a clinical interaction between low molecular weight heparin and non-steroidal analgesics after total hip replacement?" Ann R Coll Surg Engl 77 (1995): 395. [PMID: 7486773]
10	Product Information. Arixtra (fondaparinux). Organon, West Orange, NJ.
11	Product Information. Fragmin (dalteparin). Pharmacia and Upjohn, Kalamazoo, MI.
12	Product Information. Innohep (tinzaparin) DuPont Pharmaceuticals, Wilmington, DE.
13	Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
14	Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
15	Product Information. Orgaran (danaparoid). Organon, West Orange, NJ.
16	Product Information. Acova (argatroban) SmithKline Beecham, Philadelphia, PA.
17	Product Information. Angiomax (bivalirudin) The Medicines Compny, Cambridge, MA.
18	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
19	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
20	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
21	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
22	Product Information. Kengreal (cangrelor). The Medicines Company, Parsippany, NJ.
23	Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
24	Klinkhardt U, Kirchmaier CM, Westrup D, Graff J, Mahnel R, Breddin HK, Harder S "Ex vivo-in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A." Clin Pharmacol Ther 67 (2000): 305-13. [PMID: 10741635]
25	O'Donoghue M, Antman EM, Braunwald E, et al. "The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Pla" J Am Coll Cardiol 54 (2009): 678-85. [PMID: 19679245]
26	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
27	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
28	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
29	Product Information. Defitelio (defibrotide). Jazz Pharmaceuticals, Palo Alto, CA.
30	Product Information. Ipravask (desirudin). Aventis Pharmaceuticals, Swiftwater, PA.
31	Product Information. Pradaxa (dabigatran). Boehringer-Ingelheim, Ridgefield, CT.
32	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
33	Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
34	Adderhuis KM, Deckers JW, Lincoff AM, et al. "Risk of stroke associated with abciximab among patients undergoing percutaneous coronary intervention." JAMA 286 (2001): 78-82. [PMID: 11434830]
35	Blankenship JC "Bleeding complications of glycoprotein IIb-IIIa receptor inhibitors." Am Heart J 138 (1999): s287-96. [PMID: 10502234]
36	Hirsch J, Dalen J, Guyatt G, American College of Chest Physicians "The sixth (2000) ACCP guidelines for antithrombotic therapy for prevention and treatment of thrombosis. American College of Physicians." Chest 119(1 Suppl) (2001): 1S-2S. [PMID: 11157638]
37	Juran NB "Minimizing bleeding complications of percutaneous coronary intervention and glycoprotein IIb-IIIa antiplatelet therapy." Am Heart J 138 (1999): s297-306. [PMID: 10502235]
38	Product Information. Aggrastat (tirofiban). Merck & Co, Inc, West Point, PA.
39	Caillard S, Leray C, Kunz K, Gachet C, Offner M, Wiesel ML, Hannedouchte T, Cazenave JP, Moulin B "Effects of cerivastatin on lipid profiles, lipid peroxidation and platelet and endothelial activation in renal transplant recipients." Transplant Proc 32 (2000): 2787-8. [PMID: 11134806]
40	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
41	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
42	Cerner Multum, Inc. "Canadian Product Information.".
43	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
44	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
45	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
46	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
47	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
48	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
49	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
50	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
51	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
52	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
53	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
54	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
55	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
56	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
57	Product Information. Xiaflex (collagenase clostridium histolyticum). Auxilium Pharmaceuticals Inc, Norristown, PA.
58	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
59	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
60	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
61	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
62	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
63	Wilhite DB, Comerota AJ, Schmieder FA, Throm RC, Gaughan JP, Rao AK "Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time." J Vasc Surg 38 (2003): 710-3
64	Mallikaarjun S, Forbes WP, Bramer SL "Interaction potential and tolerability of the coadministration of cilostazol and aspirin." Clin Pharmacokinet 37 (1999): 87-93
65	Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
66	Alderman CP, Seshadri P, Ben-Tovim DI "Effects of serotonin reuptake inhibitors on hemostasis." Ann Pharmacother 30 (1996): 1232-4. [PMID: 8913401]
67	Aranth J, Lindberg C "Bleeding, a side effect of fluoxetine." Am J Psychiatry 149 (1992): 412. [PMID: 1536285]
68	Bannister SJ, Houser VP, Hulse JD, Kisicki JC, Rasmussen JG "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand Suppl 350 (1989): 102-6. [PMID: 2530759]
69	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
70	Claire RJ, Servis ME, Cram DL Jr "Potential interaction between warfarin sodium and fluoxetine." Am J Psychiatry 148 (1991): 1604. [PMID: 1928485]
71	Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64. [PMID: 12523917]
72	de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S "Intracranial haemorrhage and use of selective serotonin reuptake inhibitors." Br J Clin Pharmacol 50 (2000): 43-7. [PMID: 10886117]
73	de Abajo FJ, Rodriguez LA, Montero D "Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study." BMJ 319 (1999): 1106-9. [PMID: 10531103]
74	de Maistre E, Allart C, Lecompte T, Bollaert PE "Severe bleeding associated with use of low molecular weight heparin and selective serotonin reuptake inhibitors." Am J Med 113 (2002): 530-2. [PMID: 12427509]
75	Dent LA, Orrock MW "Warfarin-fluoxetine and diazepam-fluoxetine interaction." Pharmacotherapy 17 (1997): 170-2. [PMID: 9017779]
76	Ford MA, Anderson ML, Rindone JP, Jaskar DW "Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin." J Clin Psychopharmacol 17 (1997): 110-2. [PMID: 10950474]
77	Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B "Paroxetine decreases platelet serotonin storage and platelet function in human beings." Clin Pharmacol Ther 68 (2000): 435-42. [PMID: 11061584]
78	Humphries JE, Wheby MS, VandenBerg SR "Fluoxetine and the bleeding time." Arch Pathol Lab Med 114 (1990): 727-8. [PMID: 2363631]
79	Krivy J, Wiener J "Sertraline and platelet counts in idiopathic thrombocytopenia purpura." Lancet 345 (1995): 132. [PMID: 7815874]
80	Leung M, Shore R "Fluvoxamine-associated bleeding." Can J Psychiatry 41 (1996): 604-5. [PMID: 8946088]
81	Messiha FS "Fluoxetine - adverse effects and drug-drug interactions." J Toxicol Clin Toxicol 31 (1993): 603-30. [PMID: 8254702]
82	Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2. [PMID: 8166328]
83	Pai VB, Kelly MW "Bruising associated with the use of fluoxetine." Ann Pharmacother 30 (1996): 786-8. [PMID: 8826562]
84	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
85	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
86	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
87	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
88	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
89	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
90	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
91	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
92	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
93	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
94	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
95	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
96	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
97	Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30. [PMID: 9796863]
98	Skop BP, Brown TM "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors." Psychosomatics 37 (1996): 12-6. [PMID: 8600488]
99	Woolfrey S, Gammack NS, Dewar MS, Brown PJ "Fluoxetine-warfarin interaction." BMJ 307 (1993): 241. [PMID: 8369688]
100	Yaryura-Tobias JA, Kirschen H, Ninan P, Mosberg HJ "Fluoxetine and bleeding in obsessive-compulsive disorder." Am J Psychiatry 148 (1991): 949. [PMID: 2053641]
101	Layton D, Clark DWJ, Pearce GL, Shakir SAW "Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England." Eur J Clin Pharmacol 57 (2001): 167-76. [PMID: 11417450]
102	Tata LJ, Fortun PJ, Hubbard RB, et al. "Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?" Aliment Pharmacol Ther 22 (2005): 175-81. [PMID: 16091054]
103	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
104	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
105	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
106	Product Information. Ventavis (iloprost). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
107	Burnham BE "Garlic as a possible risk for postoperative bleeding." Plast Reconstr Surg 95 (1995): 213. [PMID: 7809259]
108	Chutani SK, Bordia A "The effect of fried versus raw garlic on fibrinolytic activity in man." Atherosclerosis 38 (1981): 417-21. [PMID: 7225179]
109	Evans V "Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use." J Neurosci Nurs 32 (2000): 229-32. [PMID: 10994537]
110	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
111	German K, Kumar U, Blackford HN "Garlic and the risk of TURP bleeding." Br J Urol 76 (1996): 518. [PMID: 7551902]
112	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
113	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
114	Kiesewetter H, Jung F, Jung EM, Mrowietz C, Kosciehlny J, Wenzel E "Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack." Eur J Clin Pharmacol 45 (1993): 333-6. [PMID: 8299665]
115	Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S "Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects." Arzneimittelforschung 43 (1993): 119-22. [PMID: 8457236]
116	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
117	Morris J, Burke V, Mori TA, Vandongen R, Beilin LJ "Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study." Clin Exp Pharmacol Physiol 22 (1995): 414-7. [PMID: 8582091]
118	Steiner M, Lin RS "Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract." J Cardiovasc Pharmacol 31 (1998): 904-8. [PMID: 9641475]
119	Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82. [PMID: 11144706]
120	Apitz-Castro R, Escalante J, Vargas R, Jain MK "Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets." Thromb Res 42 (1986): 303-11. [PMID: 3520940]
121	Mulrow C, Lawrence V, Ackermann R, et al. Garlic: effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects.?Evid Rep Technol Assess (Summ). 2000;(20):1-4. [PMID: 11089496]
122	Jiang X, Williams KM, Liauw WS, et al. "Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects." Br J Clin Pharmacol 59 (2005): 425-32. [PMID: 15801937]
123	Kruth P, Brosi E, Fux R, Morike K, Gleiter CH "Ginger-associated overanticoagulation by phenprocoumon." Ann Pharmacother 38 (2004): 257-60. [PMID: 14742762]
124	Benjamin J, Muir T, Briggs K, Pentland B "A case of cerebral haemorrhage - can Ginkgo biloba be implicated?." Postgrad Med J 77 (2001): 112-3. [PMID: 11161079]
125	Chung KF, McCusker M, Page CP, Dent G, Guinot P, Barnes PJ "Effect of ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet acitivating factor in man." Lancet 1 (1987): 248-51. [PMID: 2880069]
126	Cupp MJ "Herbal remedies: adverse effects and drug interactions." Am Fam Physician 59 (1999): 1239-45. [PMID: 10088878]
127	Engelsen J, Nielsen JD, Winther K "Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial." Thromb Haemost 87 (2002): 1075-6. [PMID: 12083489]
128	Fessenden JM, Wittenborn W, Clarke L "Gingko biloba: A case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy." Am Surg 67 (2001): 33-5. [PMID: 11206893]
129	Fong KC, Kinnear PE "Retrobulbar haemorrhage associated with chronic Gingko biloba ingestion." Postgrad Med J 79 (2003): 531-2. [PMID: 13679551]
130	Jayasekera N, Moghal A, Kashif F, Karalliedde L "Herbal medicines and postoperative haemorrhage." Anaesthesia 60 (2005): 725-6. [PMID: 15960738]
131	Matthews MK Jr "Association of Ginko biloba with intracerebral hemorrhage." Neurology 50 (1998): 1933-4. [PMID: 9633781]
132	Rosenblatt M, Mindel J "Spontaneous hyphema associated with ingestion of Ginkgo biloba extract." N Engl J Med 336 (1997): 1108. [PMID: 9091822]
133	Rowin J, Lewis SL "Spontaneous bilateral subdural hematomas associated with chronic Gingko biloba ingestion." Neurology 46 (1996): 1775-6. [PMID: 8649594]
134	Sierpina VS, Wollschlaeger B, Blumenthal M "Ginkgo biloba." Am Fam Physician 68 (2003): 923-6. [PMID: 13678141]
135	Wolf HR "Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?" Drugs R D 7 (2006): 163-72. [PMID: 16752942]
136	Ang-Lee MK, Moss J, Yuan CS "Herbal medicines and perioperative care." JAMA 286 (2001): 208-16. [PMID: 11448284]
137	Hodges PJ, Kam PC "The peri-operative implications of herbal medicines." Anaesthesia 57 (2002): 889-99. [PMID: 12190754]
138	Janetzky K, Morreale AP "Probable interaction between warfarin and ginseng." Am J Health Syst Pharm 54 (1997): 692-3. [PMID: 9075501]
139	Yuan CS, Wei G, Dey L, et al. "Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial." Ann Intern Med 141 (2004): 23-7. [PMID: 15238367]
140	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
141	Li XL, Steiner M "Fish oil: a potent inhibitor of platelet adhesiveness." Blood 76 (1990): 938-45. [PMID: 2118400]
142	Product Information. Vascepa (icosapent). Amarin Pharmaceuticals Inc, Warren, NJ.
143	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
144	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
145	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
146	Canadian Pharmacists Association.
147	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
148	Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, et al "Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status." Am J Clin Nutr 80 (2004): 143-8. [PMID: 15213041]
149	Murohara T, Ikeda H, Otsuka Y, Aoki M, Takajo Y, et al "Inhibition of platelet adherence to Mononuclear cells by alpha-tocopherol: role of P-selection." Circulation 110 (2004): 141-8. [PMID: 15197142]
150	Vitamin K, vitamin E and the coumarin drugs. Nutr Rev 40 (1982): 180-2. [PMID: 7121898]
151	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
152	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
153	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
154	Celestini A, Pulcinelli FM, Pignatelli P, et al. "Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets." Haematologica 87 (2002): 420-6. [PMID: 11940487]
155	Corrigan JJ "The effect of vitamin E on warfarin-induced vitamin K deficiency." Ann N Y Acad Sci 393 (1982): 361-8. [PMID: 6959563]
156	Corrigan JJ, Ulfers LL "Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency." Am J Clin Nutr 34 (1981): 1701-5. [PMID: 7282596]
157	Freedman JE, Farhat JH, Loscalzo J, Keaney JF "Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C--dependent mechanism." Circulation 94 (1996): 2434-40. [PMID: 8921785]
158	Gonzalez-Correa JA, Arrebola MM, Guerrero A, et al. "Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood." Platelets 16(3-4) (2005): 171-9. [PMID: 16011961]
159	Helson L "The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors." Thromb Res 35 (1984): 11-8. [PMID: 6474408]
160	Jandak J, Steiner M, Richardson PD "Alpha-tocopherol, an effective inhibitor of platelet adhesion." Blood 73 (1989): 141-9. [PMID: 2910355]
161	Kakishita E, Suehiro A, Oura Y, Nagai K "Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood." Thromb Res 60 (1990): 489-99. [PMID: 2082481]
162	Kim JM, White RH "Effect of vitamin E on the anticoagulant response to warfarin." Am J Cardiol 77 (1996): 545-6. [PMID: 8629604]
163	Liu M, Wallmon A, Olsson-Mortlock C, Wallin R, Saldeen T "Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms." Am J Clin Nutr 77 (2003): 700-6. [PMID: 12600864]
164	Mardla V, Kobzar G, Samel N "Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin." Platelets 15 (2004): 319-24. [PMID: 15370103]
165	Megavitamin E supplementation and vitamin K-dependent carboxylation. Nutr Rev 41 (1983): 268-70. [PMID: 6358960]
166	Schrogie JJ "Coagulopathy and fat-soluble vitamins." JAMA 232 (1975): 19. [PMID: 1172961]
167	Stampfer MJ, Jakubowski JA, Faigel D, Vaillancourt R, Deykin D "Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels." Am J Clin Nutr 47 (1988): 700-6. [PMID: 3128100]
168	Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C "Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis." Pharmacotherapy 27 (2007): 1237-47. [PMID: 17723077]
169	Lambert JP, Cormier J "Potential interaction between warfarin and boldo-fenugreek." Pharmacotherapy 21 (2001): 509-12. [PMID: 11310527]
170	Saeed SA, Gilani AH "Antithrombotic activity of clove oil." J Pak Med Assoc 44 (1994): 112-5. [PMID: 8078176]
171	Srivasta KC "Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]" Prostaglandins Leukot Essent Fatty Acids 48 (1993): 363-72. [PMID: 8321872]
172	Srivstava KC, Malhotra N "Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets." Prostaglandins Leukot Essent Fatty Acids 42 (1991): 73-81. [PMID: 2011614]
173	Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
174	Yang X, Thomas DP, Zhang X, et al "Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation." Arterioscler Thromb Vasc Biol 26 (2006): 85-90. [PMID: 16239599]

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