Details of Drug

Drug General Information (ID: D0585)
Drug Name	Eplerenone
Drug Type	Small molecule
Drug Synonymous	Epoxymexrenone; Inspra; Selara; CGP-30083; Inspra (TN); SC-66110; Eplerenone (JAN/USAN/INN); Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone; 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone Click to Show/Hide
Disease Class	BD10-BD1Z: Heart failure
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H30O6
InChI	1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
InChIKey	JUKPWJGBANNWMW-VWBFHTRKSA-N
Canonical SMILES	CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC
External Link
	Pubchem ID	443872
	CAS Number	107724-20-9
	CHEBI ID	31547
	TTD ID	D0Q4SD
	INTEDE ID	DR0592

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM042 Additive hypotensive effects BM058 Increased risk of hyperkalemia BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Eplerenone
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 54
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[2]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[2]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[3], [2], [4]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[3], [2], [4]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[2]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[3], [2], [4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[3], [2], [4]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[3], [2], [4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[3], [2], [4]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[3], [2], [4]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[2]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[3], [2], [4]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[3], [2], [4]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[2]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[3], [2], [4]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[3], [2], [4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[3], [2], [4]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[3], [2], [4]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[5], [6], [7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[3], [2], [4]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[3], [2], [4]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[3], [2], [4]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[3], [2], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[3], [2], [4]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[3], [2], [4]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[3], [2], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[3], [2], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[3], [2], [4]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[3], [2], [4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[76]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[88], [89]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[94]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[108]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [46], [109]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[110]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[119]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[46], [127]
	CYP450 enzyme induction					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[85]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[46], [87]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[3], [90]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[93]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[117]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[46], [124]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[46], [126]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [46], [130]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [46], [131], [130]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[46], [133]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3], [46], [135], [136]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [46], [130]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[137], [3], [46], [47], [138]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[137], [3], [46], [47], [138]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[139], [140], [141], [142], [143]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[137], [3], [46], [47], [138]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[137], [3], [46], [47], [138]
D0901		Lemborexant	C22H20F2N4O2	56944144	Minor		Inter Info	[3], [47], [138]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[139], [140], [141], [142], [143]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[137], [3], [46], [47], [138]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[137], [3], [46], [47], [138]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[3], [47], [138]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[137], [3], [46], [47], [138]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[137], [3], [46], [47], [138]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[137], [3], [46], [47], [138]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[128], [129]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [35], [132], [128]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[128], [129]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[8]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[43], [44], [45]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[43], [44], [45]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[43], [44], [45]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[48], [49], [50]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[48], [49], [50]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[43], [44], [45]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[43], [44], [45]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[43], [44], [45]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[43], [44], [45]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[43], [44], [45]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[43], [44], [45]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[43], [44], [45]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[3], [74], [75]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[43], [44], [45]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[65], [67], [69]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[77], [78], [79]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[77], [80], [81]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[48], [49], [50]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[82], [83], [84]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[43], [44], [45]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[43], [44], [45]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[3], [46], [86]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[43], [44], [45]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[43], [44], [45]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[43], [44], [45]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[43], [44], [45]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[43], [44], [45]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[3], [46], [86]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[43], [44], [45]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[43], [44], [45]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[43], [44], [45]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[43], [44], [45]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[43], [44], [45]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[43], [44], [45]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[43], [44], [45]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[3], [46], [86]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[46], [91], [92]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[43], [44], [45]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[3], [46], [95]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[43], [44], [45]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[43], [44], [45]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[46], [91], [92]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[77], [80], [111]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[46], [115], [116]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[43], [44], [45]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[118]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[43], [44], [45]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[120], [121], [122]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[43], [44], [45]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[43], [44], [45]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[43], [44], [45]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[43], [44], [45]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[123]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[43], [44], [45]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[43], [44], [45]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[43], [44], [45]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[125]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[46], [91], [92]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[43], [44], [45]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[43], [44], [45]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[43], [44], [45]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[43], [44], [45]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[82], [83], [84]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[43], [44], [45]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[43], [44], [45]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[43], [44], [45]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[43], [44], [45]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[43], [44], [45]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [78], [106], [107]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[43], [44], [45]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[43], [44], [45]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[43], [44], [45]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[43], [44], [45]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[43], [44], [45]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[43], [44], [45]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[43], [44], [45]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[43], [44], [45]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[82], [83], [84]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[43], [44], [45]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[43], [44], [45]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[46], [91], [92]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[43], [44], [45]
D0711		Garlic	NA	NA	Minor		Inter Info	[144], [145]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[146], [147]
	Increased risk of hyperkalemia					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Major		Inter Info	[1], [2]
D0059		Aminobenzoic acid	C7H7NO2	978	Major		Inter Info	[2], [1]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[2], [1]
D1316		Potassium acetate	C2H3KO2	517044	Major		Inter Info	[1], [2]
D1317		Potassium bicarbonate	CHKO3	516893	Major		Inter Info	[1], [2]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[1], [2]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[1], [2]
D1320		Potassium gluconate	C6H11KO7	16760467	Major		Inter Info	[1], [2]
D1321		Potassium Iodide	IK	4875	Major		Inter Info	[1], [2]
D1322		Potassium perchlorate	ClKO4	516900	Major		Inter Info	[1], [2]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[1], [2]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[1], [2]
D1645		Trimethoprim	C14H18N4O3	5578	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [1], [36], [37], [38], [39], [40], [41], [42]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[2], [1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [72], [73], [35]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[2], [1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[52], [51], [59]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[2], [1]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[2], [1]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[2], [1]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[2], [1]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[2], [1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[52], [51], [59]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[2], [1]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[52], [51], [59]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [1]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[52], [51], [59]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[2], [1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[134]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[2], [1]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[2], [1]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[2], [1]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[2], [1]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[2], [1]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[2], [1]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[2], [1]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[46], [47]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[46], [47]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[46], [47]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[46], [47]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[46], [47]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[46], [47]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[112], [113], [114]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[46], [47]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[46], [47]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[46], [47]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[46], [47]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[46], [47]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[46], [47]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[51], [52], [53], [54], [55], [2], [56], [57], [58], [59], [60]

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