Details of Drug

Drug General Information (ID: D0580)
Drug Name	Ephedrine (nasal)
Drug Type	Small molecule
Drug Synonymous	Biophedrin; Eciphin; Efedrin; Ephedral; Ephedremal; Ephedrin; Ephedrital; Ephedrol; Ephedrosan; Ephedrotal; Ephedsol; Ephendronal; Ephoxamin; Fedrin; Kratedyn; Lexofedrin; Manadrin; Mandrin; Nasol; Racephedrine; Sanedrine; Vencipon; Zephrol; CPDD 0049; D-Ephedrine; Ephedrine (TN); Ephedrine (USP); Ephedrine [USAN:BAN]; Ephedrine l-form; I-Sedrin; L-Ephedrine; L(-)-Ephedrine; L-(+)-Ephedrine; L-(-)-Ephedrine; (+)-Ephedrin; (1R,2R)-Ephedrine; (1S,2R)-Ephedrine; (L)-EPHEDRINE; 1-EPHEDRINE; 1-Sedrin Click to Show/Hide
Disease Class	CA23: Asthma
Therapeutic Class	Cns Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C10H15NO
InChI	1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChIKey	KWGRBVOPPLSCSI-WPRPVWTQSA-N
Canonical SMILES	CC(C(C1=CC=CC=C1)O)NC
External Link
	Pubchem ID	9294
	CAS Number	299-42-3
	CHEBI ID	15407
	TTD ID	D0LG8E
	INTEDE ID	DR0586

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM029 Altered urine pH BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM078 Increased risk of rapid heart rate BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ephedrine (nasal)
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[4]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[16], [17], [18]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[16], [17], [18]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[16], [17], [18]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[16], [17], [19]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[16], [17], [18]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[16], [17], [18]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[16], [17], [18]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[16], [17], [18]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[16], [17], [18]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[16], [17], [18]
Affected excretion pathways
	Altered urine pH					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0886		Lactic acid	C3H6O3	612	Moderate		Inter Info	[13], [14], [15]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[13], [14], [15]
D1478		Sodium acetate	C2H3NaO2	517045	Moderate		Inter Info	[13], [14], [15]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[13], [14], [15]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[13], [14], [15]
D1654		Tromethamine	C4H11NO3	6503	Moderate		Inter Info	[13], [14], [15]
D0111		Ascorbic acid	C6H8O6	54670067	Minor		Inter Info	[13], [14], [15]
D0070		Ammonium chloride	ClH4N	25517	Minor		Inter Info	[13], [14], [15]
D1486		Sodium phosphate, monobasic	NA	NA	Minor		Inter Info	[13], [14], [15]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [3], [5]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [3], [5]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [3], [5]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[6], [7], [8]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[9], [10], [11]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[9], [10], [11]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[12]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[6], [7], [8]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[9], [10], [11]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[6], [7], [8]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[9], [10], [11]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[6], [7], [8]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[23]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[9], [10], [11]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[6], [7], [8]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[6], [7], [8]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[24], [5]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[6], [7], [8]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[6], [7], [8]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[6], [7], [8]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[6], [7], [8]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[28], [29], [30]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[6], [7], [8]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[9], [10], [11]
	Additive hypotensive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[20], [21], [22]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[20], [21], [22]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[20], [21], [22]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[20], [21], [22]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[25], [26], [27]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0979		Maprotiline	C20H23N	4011	Minor		Inter Info	[31], [32], [33]

References
1	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
2	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
3	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
5	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
6	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
7	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
8	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
9	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
10	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
11	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
12	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
13	Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4. [PMID: 7438686]
14	Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7. [PMID: 5541135]
15	Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
16	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
17	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
18	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
19	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
20	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
21	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
22	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
23	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
24	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
25	Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
26	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
27	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
28	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
29	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
30	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
31	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
32	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
33	Briant RH, George CF "The assessment of potential drug interactions with a new tricyclic antidepressant drug." Br J Clin Pharmacol 1 (1974): 113-8

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