Details of Drug

Drug General Information (ID: D0577)
Drug Name	Entrectinib
Drug Type	Small molecule
Drug Synonymous	1108743-60-7; RXDX-101; UNII-L5ORF0AN1I; Entrectinib (RXDX-101); L5ORF0AN1I; Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-; Benzamide, N-(5-((3,5-difluorophenyl)methyl)-1H-indazol-3-yl)-4-(4-methyl-1-piperazinyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-; Entrectinib [USAN:INN]; YMX; Kinome_2659; Entrectinib(rxdx-101); Entrectinib (USAN/INN); SCHEMBL3512601; GTPL8290; CHEMBL1983268; KS-00000TSK Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer; 2B91: Colorectal cancer; 2D11: Adrenal cancer; 2C60-2C6Y: Breast cancer; 2C25: Non-small cell lung cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C31H34F2N6O2
InChI	1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
InChIKey	HAYYBYPASCDWEQ-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
External Link
	Pubchem ID	25141092
	CAS Number	1108743-60-7
	TTD ID	D0O0LS
	INTEDE ID	DR0582

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Entrectinib
Affected cellular transport
	Transporter inhibition					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[2], [3], [15]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[2], [3], [15]
D0631		Ezetimibe	C24H21F2NO3	150311	Moderate		Inter Info	[2], [3], [15]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[2], [3], [15]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[2], [3], [15]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[2], [3], [15]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[2], [3], [15]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[2], [3], [15]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[2], [3], [15]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[2], [3], [15]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[2], [3], [15]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[2], [3], [15]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[2], [3], [15]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[2], [3], [15]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[2], [3], [15]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 134
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[3], [15]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[2], [3], [15]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[2], [3], [15]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[3], [15]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2], [3], [15]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[2], [3], [15]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[2], [3], [15]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2], [3], [15]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2], [3], [15]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2], [3], [15]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2], [3], [15]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[3], [15]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[2], [3], [15]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[3], [15]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2], [3], [15]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[3], [15]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[3], [15]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [3], [15]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[3], [15]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[52], [53], [54]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[2], [3], [15]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[3], [15]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[3], [15]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2], [3], [15]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[2], [3], [15]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2], [3], [15]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[2], [3], [15]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[2], [3], [15]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2], [3], [15]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[2], [3], [15]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[2], [3], [15]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2], [3], [15]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[2], [78]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[3], [15]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[2], [3], [15]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[2], [3], [15]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2], [3], [15]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[3], [15]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[2], [3], [15]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [3], [15]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[2], [3], [15]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[3], [15]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[3], [15]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[3], [15]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2], [3], [15]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[2], [3], [15]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[146], [147]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[15]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[155], [156], [3], [136], [157], [158], [159], [160], [161], [162], [163], [164], [147], [165], [166], [167], [168]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[15]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[15]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[3], [169], [147]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [147], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[3], [279]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[15]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[284], [2], [3], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[284], [2], [3]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[15]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[308]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[309], [310], [311], [312], [313], [314], [315], [316], [317]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[15]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[15]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[322]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[15]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[15]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[15]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[323], [147]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[324], [325], [326], [327], [328], [230], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[348], [2], [3], [349], [350], [351], [352], [353], [354]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[358]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[359]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[360]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[3], [361]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[3], [15]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[15]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[3], [15]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[362]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[2], [366]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[330], [332], [343]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[324], [325], [326], [327], [328], [230], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[367], [147]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[15]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[369], [370], [371], [372], [167]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[373]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[374]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[2], [3], [15]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[15]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[375], [376]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[3], [378]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[15]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[1], [2], [3], [383], [384], [385], [386]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[2], [3], [383]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[15]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[15]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[387], [388]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[15]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [147], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[330], [332], [343]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[330], [332], [343]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[15]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[15]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[15]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[15]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[15]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[1], [2], [3]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[393]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[15]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[3], [398]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[399], [400], [401], [402]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[403]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [147], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[2], [3], [404], [405], [406], [147], [407]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[408]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[15]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[3], [15]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[15]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[412], [413]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[15]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[2], [3], [416]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[15]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[15]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[3], [15]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[15]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[417], [418], [419], [420], [421], [422], [423]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[424], [425]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[426]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[427]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[431]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[432]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[433]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[434]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[435], [436], [437], [438], [439], [440], [441]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[3], [442]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[443], [444], [445]
	CYP450 enzyme induction					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[3], [15]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[15]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[15]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[15]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[15]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[15]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[15]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[15]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[15]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[15]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[15]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [15]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[15]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[15]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[15]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[15]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[15]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[15]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[15]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[15]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [15]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[15]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[15]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[3], [15]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[3], [15]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[15]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[15]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[15]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[3], [15]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[15]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3], [15]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[15]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[15]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [15]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [15]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[15]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[15]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[15]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[3], [15]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [15]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[15]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[15]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[15]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[15]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[3], [15]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[15]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[15]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3], [15]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [15]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3], [15]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[3], [15]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[3], [15]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[44], [45]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[77]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[80]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[93]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[77]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[206], [207], [208], [2], [3], [209], [210], [211], [212], [213], [214], [215], [216]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[207], [2], [215]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[283]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [307]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[318]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[206], [207], [208], [2], [3], [209], [210], [211], [212], [213], [214], [215], [216]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[2], [3], [363], [364], [365]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[379], [380], [381], [382]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[379], [380], [381], [382]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [391]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[392]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[206], [207], [208], [2], [3], [209], [210], [211], [212], [213], [214], [215], [216]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[379], [380], [381], [382]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[410], [411]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [414], [415]
	Increased risk of prolong QT interval					Drug Num: 148
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [16]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[19]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[3], [20]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[21], [3], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [40]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [41], [42], [13], [43]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [46]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [47]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [48], [49], [13]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[50], [51]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[55]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[57], [58]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [60], [2], [3], [61], [62], [13]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[64], [1], [65]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[2], [3], [66]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[2], [67], [68]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [69], [70], [71], [72], [73], [74], [13]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[21], [3], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [75]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [76], [13]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [79], [13]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [81]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[2], [3], [82]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [13]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[64], [94], [95], [1], [2], [3], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [65], [112], [113], [114]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[115]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[116]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [125]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [48], [126], [13]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[127], [128], [1], [2], [3], [129], [130]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[131], [132], [133]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[3], [134], [135]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [136]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [137]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [48], [138], [13]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[3], [139], [140]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[2], [3], [15]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[3], [15]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[2], [3], [15]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[2], [3], [15]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[2], [3], [15]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [200], [201], [202], [203], [204], [205]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[3], [15]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[2], [3], [15]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[2], [3], [15]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [2], [3], [298], [299], [300], [301], [302], [303], [304], [305], [306]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[2], [3], [15]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[319], [320], [321]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[2], [3], [15]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[2], [3], [15]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[2], [3], [15]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[3], [15]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[2], [3], [15]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[3], [15]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[3], [15]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[2], [3], [15]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[3], [15]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[2], [3], [15]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[2], [3], [15]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[2], [3], [15]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[3], [15]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[3], [15]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[2], [3], [15]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[3], [15]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2], [3], [15]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[2], [3], [15]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[3], [15]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [368]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[2], [3], [15]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[2], [3], [15]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[2], [3], [15]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[2], [3], [15]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[2], [3], [15]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[377]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[2], [3], [15]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[2], [3], [15]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[2], [3], [15]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[2], [3], [15]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[2], [3], [15]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[2], [3], [15]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[2], [3], [15]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[2], [3], [15]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[2], [3], [15]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[2], [3], [15]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[2], [3], [15]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[3], [15]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[389], [390]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[2], [3], [15]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[2], [3], [15]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[3], [15]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[2], [3], [15]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[2], [3], [15]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[3], [15]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[2], [3], [15]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[2], [3], [15]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[2], [3], [15]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [15]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[2], [3], [15]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[2], [3], [15]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[2], [3], [15]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[2], [3], [15]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2], [3], [15]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[2], [3], [15]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[394], [395]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[2], [3], [15]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[2], [3], [15]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[3], [15]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[2], [3], [15]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[2], [3], [15]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[2], [3], [15]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[2], [3], [15]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[2], [3], [15]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[2], [3], [15]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[3], [141], [142], [143], [144], [145], [139], [140]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[2], [3], [15]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[2], [3], [15]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[3], [15]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[2], [3], [15]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[2], [3], [15]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[2], [3], [15]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[2], [3], [15]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[2], [3], [15]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[3], [15]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[2], [3], [15]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[2], [3], [15]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[2], [3], [15]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[2], [3], [15]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[2], [3], [15]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[3], [15]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[2], [3], [15]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[2], [3], [15]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[2], [3], [15]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[2], [3], [15]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[2], [3], [15]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [428], [429], [430]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [446]
	Increased risk of ventricular arrhythmias					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[14]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[17], [18]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[56]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [59]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[63], [43]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[148], [3], [149], [150], [151], [152], [153], [154]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [355], [356], [357]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [282]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[2], [3], [282]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[183], [193], [196]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [355], [356], [357]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[183], [193], [196]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[183], [193], [196]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [280], [281], [282]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[183], [193], [196]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[2], [3], [282]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [396], [397]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[183], [193], [196]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [396], [397]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[183], [193], [196]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [396], [397]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[2], [356], [357]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [409]

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186	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
187	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
188	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
189	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
190	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
191	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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263	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
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341	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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357	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
358	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
359	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
360	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
361	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
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378	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
379	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
380	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
381	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
382	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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388	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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393	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
394	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
395	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
396	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
397	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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408	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
409	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
410	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
411	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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421	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
422	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
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426	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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430	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
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432	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
433	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
434	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
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440	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
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444	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
445	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
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