Details of Drug

Details of Drug

 Drug General Information (ID: D0462)
  Drug Name
Dextran (-1)
  Drug Type Small molecule
  Drug Synonymous
Isomaltotri-itol; Isomaltosaccharide; CHEBI:27649; DEXTRAN; alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-D-glucose; O-alpha-D-Glucopyranosyl-(1.6)-O-alpha-D-glucopyranosyl-(1.6)-D-glucose; AC1NUSPK; SCHEMBL206877; CHEMBL1697742; ZINC64622163; I14-57292
    Click to Show/Hide
  Disease Class DB61-GB90: Thrombosis
  Therapeutic Class Plasma Expanders
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H32O16
  InChI 1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
  InChIKey FZWBNHMXJMCXLU-UHFFFAOYSA-N
  Canonical SMILES C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O
  External Link
Pubchem ID 4125253
CAS Number 9004-54-0
TTD ID D00UJF

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM050  Increased risk of bleeding
  Relation Graph
 Full list of drugs interacting with Dextran (-1)
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  21
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Major    Inter Info   
[1], [2], [3]
D0250
 
Caplacizumab
 
NA
 
NA
Major    Inter Info   
[4], [1], [5]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Major    Inter Info   
[6], [7], [8]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Major    Inter Info   
[9], [10]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Major    Inter Info   
[1], [11]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Major    Inter Info   
[12], [13]
D0447
 
Desirudin
 
C287H440N80O110S6
 
16129703 
Major    Inter Info   
[12], [2], [14]
D1718
 
Zanubrutinib
 
C27H29N5O3
 
135565884 
Major    Inter Info   
[9]
D0537
 
Drotrecogin alfa
 
NA
 
NA
Major    Inter Info   
[15]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Major    Inter Info   
[16]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Major    Inter Info   
[6], [7], [8]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Major    Inter Info   
[6], [7], [8]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Major    Inter Info   
[9], [17]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Major    Inter Info   
[1], [18]
D1380
 
Ramucirumab
 
NA
 
NA
Major    Inter Info   
[9], [19]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Major    Inter Info   
[20]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Major    Inter Info   
[21]
D1140
 
Niraparib
 
C19H20N4O
 
24958200 
Moderate    Inter Info   
[1], [22]
D1178
 
Omega-3 fatty acids
 
C60H92O6
 
56842239 
Moderate    Inter Info   
[1], [23], [24]
D1815
 
Icosapent
 
C20H30O2
 
446284 
Moderate    Inter Info   
[1], [23], [24]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[25], [26]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
3 Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
6 Product Information. Fragmin (dalteparin). Pharmacia and Upjohn, Kalamazoo, MI.
7 Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
8 Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
9 Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
10 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
11 Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
12 Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
13 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
14 Product Information. Ipravask (desirudin). Aventis Pharmaceuticals, Swiftwater, PA.
15 Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
16 Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
17 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
18 Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
19 Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
20 Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
21 Product Information. Zontivity (vorapaxar). Merck &amp Company Inc, Whitehouse Station, NJ.
22 Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
23 Li XL, Steiner M "Fish oil: a potent inhibitor of platelet adhesiveness." Blood 76 (1990): 938-45. [PMID: 2118400]
24 Product Information. Vascepa (icosapent). Amarin Pharmaceuticals Inc, Warren, NJ.
25 Canadian Pharmacists Association.
26 Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.