Details of Drug

Details of Drug

 Drug General Information (ID: D0461)
  Drug Name
Dexrazoxane
  Drug Type Small molecule
  Drug Synonymous
24584-09-6; Zinecard; (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione); Cardioxane; ICRF-187; Dexrazoxano; Dexrazoxanum; Dextrorazoxane; Dexrazoxanum [INN-Latin]; Dexrazoxano [INN-Spanish]; Desrazoxane; Eucardion; ADR 529; ICRF 187; (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione; Dexrazone; ADR-529; (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; HSDB 7319; UNII-048L81261F; NSC169780; dyzoxane; BRN 5759131; CHEBI:50223; 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione; NSC 169780; AK-72797; Razoxanum; Cardioxane; Dyzoxane; Savene; TopoTect; Totect; Dexrazoxane HCl; Dexrazoxane hydrochloride; ICRF 187 hydrochloride; Cardioxane (TN); Dexrazoxane (TN); Totect (TN); Zinecard (TN); Dexrazoxane (USAN/INN); Dexrazoxane [USAN:BAN:INN]; Soluble ICRF (L-isosomer); Razoxane, (S)-Isomer; Totect, ICRF-187, Zinecard, Cardioxane, Dexrazoxane Hydrochloride;(+)-(S)-4,4'-Propylenedi-2,6-piperazinedione; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)-(9CI); 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione; 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride; Icrf-187
    Click to Show/Hide
  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C11H16N4O4
  InChI 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
  InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N
  Canonical SMILES CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
  External Link
Pubchem ID 71384
CAS Number 24584-09-6
CHEBI ID 50223
TTD ID D07XVN
VARIDT ID DR00417

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM043  Additive immunosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Dexrazoxane
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[11]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[11]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1849
 
Mumps virus strain B level jeryl lynn live antigen
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1881
 
Rotavirus vaccine
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1882
 
Rubella virus vaccine
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[4], [5], [6]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Major    Inter Info   
[7]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1922
 
Yellow Fever Vaccine
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
   Antagonize the effect of probiotics Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1749
 
Bifidobacterium longum infantis
 
NA
 
NA
Moderate    Inter Info   
[8], [9], [10]
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[8], [9], [10]
   Attenuated pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[12], [13], [14]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[12], [13], [14]
References
1 Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
2 Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
3 Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
4 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
5 Cerner Multum, Inc. "Australian Product Information.".
6 Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
7 Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
8 Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
9 Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
10 Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
11 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
14 Product Information. Zinecard (dexrazoxane). Pfizer U.S. Pharmaceuticals Group, New York, NY.