Details of Drug

Drug General Information (ID: D0452)
Drug Name	Deutetrabenazine
Drug Type	Small molecule
Drug Synonymous	Dutetrabenazine; Austedo; SD809; SD-809; SD 809; 1392826-25-3; Deutetrabenazine [USAN:INN] Click to Show/Hide
Disease Class	8A02: Dystonic disorder; 8A01: Choreiform disorder
Therapeutic Class	Vmat2 Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C19H27NO3
InChI	1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1/i3D3,4D3
InChIKey	MKJIEFSOBYUXJB-VFJJUKLQSA-N
Canonical SMILES	CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
External Link
	Pubchem ID	73437646
	CAS Number	1392826-25-3
	TTD ID	D0E7ZU
	INTEDE ID	DR0445
	VARIDT ID	DR01127

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM034 Additive antidopaminergic effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Deutetrabenazine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1]
D0338		Cinacalcet	C22H22F3N	156419	Major		Inter Info	[1]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Major		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[207]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [208]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[209]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[4], [220]
Pharmacodynamic additive effects
	Additive antidopaminergic effects					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[1]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[1]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[1]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[1]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[1]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[102], [3], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[1]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1]
D1393		Reserpine	C33H40N2O9	5770	Major		Inter Info	[48], [1]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[1]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1]
	Additive CNS depression effects					Drug Num: 229
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[137], [138]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[166], [167], [168]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[166], [167], [168]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[166], [167], [168]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[1]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[166], [167], [168]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[166], [167], [168]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[166], [167], [168]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[166], [167], [168]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[166], [167], [168]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[202]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[166], [167], [168]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[166], [167], [168]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[166], [167], [168]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[166], [167], [168]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[166], [167], [168]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[166], [167], [168]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[166], [167], [168]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[166], [167], [168]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[166], [167], [168]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[166], [167], [168]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[166], [167], [168]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[166], [167], [168]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[203], [204]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[166], [167], [168]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[166], [167], [168]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[166], [167], [168]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[166], [167], [168]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[166], [167], [168]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[166], [167], [168]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[166], [167], [168]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[166], [167], [168]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[166], [167], [168]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[166], [167], [168]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[166], [167], [168]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[166], [167], [168]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[166], [167], [168]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[166], [167], [168]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[166], [167], [168]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[166], [167], [168]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[166], [167], [168]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[1], [205], [206]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[1]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[166], [167], [168]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[166], [167], [168]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[166], [167], [168]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[1], [205], [206]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[166], [167], [168]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1]
D1675		Valerian	NA	NA	Moderate		Inter Info	[166], [167], [168]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[166], [167], [168]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[166], [167], [168]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[166], [167], [168]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[166], [167], [168]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[166], [167], [168]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[166], [167], [168]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[166], [167], [168]
D0488		Difenoxin	C28H28N2O2	34328	Moderate		Inter Info	[166], [167], [168]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[166], [167], [168]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[166], [167], [168]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[166], [167], [168]
D0504		Diphenoxylate	C30H32N2O2	13505	Moderate		Inter Info	[166], [167], [168]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[1], [205], [206]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1], [205], [206]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[166], [167], [168]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[166], [167], [168]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[166], [167], [168]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[166], [167], [168]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[166], [167], [168]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[214], [215], [216], [4], [217]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[166], [167], [168]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[166], [167], [168]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[166], [167], [168]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[166], [167], [168]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[166], [167], [168]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[219]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[166], [167], [168]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[166], [167], [168]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[166], [167], [168]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[166], [167], [168]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[166], [167], [168]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[166], [167], [168]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[1]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[166], [167], [168]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[166], [167], [168]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[221]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[166], [167], [168]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[203], [204]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[1]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[166], [167], [168]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[166], [167], [168]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[166], [167], [168]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[166], [167], [168]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[166], [167], [168]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[166], [167], [168]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[166], [167], [168]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[166], [167], [168]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[166], [167], [168]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[166], [167], [168]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[166], [167], [168]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[166], [167], [168]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[166], [167], [168]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[166], [167], [168]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[166], [167], [168]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[166], [167], [168]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[1]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[166], [167], [168]
D1183		Opium	NA	NA	Moderate		Inter Info	[166], [167], [168]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[166], [167], [168]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[1]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[166], [167], [168]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[166], [167], [168]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[166], [167], [168]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[166], [167], [168]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[166], [167], [168]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[166], [167], [168]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[166], [167], [168]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[166], [167], [168]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[166], [167], [168]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[166], [167], [168]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[166], [167], [168]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[166], [167], [168]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[166], [167], [168]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[166], [167], [168]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[166], [167], [168]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[166], [167], [168]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[166], [167], [168]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[166], [167], [168]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[166], [167], [168]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[166], [167], [168]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[1]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[166], [167], [168]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[166], [167], [168]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[166], [167], [168]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[166], [167], [168]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[166], [167], [168]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[166], [167], [168]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[166], [167], [168]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[1]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[166], [167], [168]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[166], [167], [168]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[166], [167], [168]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[166], [167], [168]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[166], [167], [168]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[166], [167], [168]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[166], [167], [168]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[239], [4], [3]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[166], [167], [168]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[166], [167], [168]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[166], [167], [168]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[166], [167], [168]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[166], [167], [168]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[166], [167], [168]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[166], [167], [168]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[166], [167], [168]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[166], [167], [168]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[166], [167], [168]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[166], [167], [168]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[1]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[166], [167], [168]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[166], [167], [168]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[166], [167], [168]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[166], [167], [168]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[166], [167], [168]
	Additive hypertensive effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [47], [48]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1], [86], [48]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1], [86], [48]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1], [86], [48]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1], [86], [48]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1], [86], [48]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[1], [86], [48]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[1], [86], [48]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[1], [86], [48]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[1], [86], [48]
	Increased risk of prolong QT interval					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[2], [3], [4], [16]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[19]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2], [3], [4], [20]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[21], [4], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[2], [3], [4], [40], [41], [42]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[43]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[44]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[45]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[46]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[4], [49]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[2], [3], [4], [51]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[2], [3], [4], [52]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[53]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[2], [54], [3], [4], [55], [56], [14]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[59], [60], [61], [2], [3], [4], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[60], [2], [3], [4], [82], [83], [84]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[21], [4], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[2], [3], [4], [85]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[4], [89], [14]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[3], [4], [90]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[2], [3], [4], [91], [14]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[2], [3], [4], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [14]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[2], [3], [4], [116]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[59], [60], [61], [2], [3], [4], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[2], [3], [4], [117]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[118]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[119]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[120], [121], [122], [123], [124], [125], [126], [127]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[2], [3], [4], [128]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[4], [129], [130], [14]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2], [3], [4], [129], [66], [131], [132], [14]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[133], [134], [2], [3], [4], [135], [136]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[60], [2], [3], [4], [139], [140], [64], [66], [68], [141], [69], [70], [142], [72], [73], [74], [75], [143], [79], [84], [144]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[2], [3], [4], [145], [129], [146], [147], [148], [14]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[2], [3], [4], [149]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[2], [3], [4], [150]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[2], [3], [4], [151]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[2], [3], [4], [129], [152], [14]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[3], [4], [213]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[3], [4], [218]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[4]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[222], [223]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[2], [3], [224]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[225], [226]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[229], [230], [231], [232], [233], [234], [235], [236], [237], [238]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[4], [153], [154], [155], [156], [157], [158], [159]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[3], [240], [241], [242]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[2], [3], [4], [243], [244], [245], [246]
	Increased risk of ventricular arrhythmias					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[15]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[17], [18]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[3], [50]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[2], [3], [4], [57], [58]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[4], [87], [88]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[2], [160], [3], [4], [161], [162], [163], [40], [164], [165]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[3], [4], [201]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[182], [192], [195]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[2], [3], [4], [210], [211], [212]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[2], [3], [4], [210], [211], [212]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[182], [192], [195]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[182], [192], [195]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[2], [3], [4], [199], [200], [201]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[4], [227], [228]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[4], [227], [228]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[3], [4], [201]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[2], [3], [4], [210], [211], [212]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[182], [192], [195]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[4], [227], [228]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[2], [3], [4], [210], [211], [212]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[182], [192], [195]

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151	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
152	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
153	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
154	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
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