Details of Drug

Drug General Information (ID: D0443)
Drug Name	Denosumab
Drug Type	Monoclonal antibody
Drug Synonymous	Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN) Click to Show/Hide
Disease Class	FB83: Low bone mass disorder; FA20: Rheumatoid arthritis; 2C82: Prostate cancer
Therapeutic Class	Bone Resorption Inhibitors
External Link
External Link	TTD ID	D08WSY

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM063 Increased risk of hypocalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Denosumab
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 213
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0004		Abatacept	NA	NA	Moderate		Inter Info	[4]
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[4]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[4]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[4]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[4]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[4]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Moderate		Inter Info	[6], [4]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[4]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[4]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[4]
D0147		Basiliximab	NA	NA	Moderate		Inter Info	[4]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[4]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[4]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[4]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[4]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[4]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[4]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[4]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[4]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[4]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[4]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[4]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[4]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[4]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[4]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[4]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[4]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[4]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[4]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[4]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[4]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[4]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[6], [4]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[4]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[4]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[4]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[4]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[6], [4]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Moderate		Inter Info	[6], [4]
D0118		Atezolizumab	NA	NA	Moderate		Inter Info	[4]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[4]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[4]
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[4]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[4]
D0151		Belatacept	NA	NA	Moderate		Inter Info	[4]
D0152		Belimumab	NA	NA	Moderate		Inter Info	[4]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[4]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[4]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[6], [4]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4]
D0209		Brodalumab	NA	NA	Moderate		Inter Info	[4]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[4]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[4]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[6], [4]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[4]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[4]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[4]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[4]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[4]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[4]
D0540		Dupilumab	NA	NA	Moderate		Inter Info	[4]
D0541		Durvalumab	NA	NA	Moderate		Inter Info	[4]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[4]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[4]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[4]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[4]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[4]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[4]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[4]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4]
D0801		Inebilizumab	NA	NA	Moderate		Inter Info	[4]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[6], [4]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[4]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[4]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[4]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[4]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[4]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[4]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[4]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[4]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[4]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[4]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[4]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[4]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[4]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[4]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[4]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[4]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[4]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[4]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[4]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[4]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[4]
D1410		Risankizumab	NA	NA	Moderate		Inter Info	[4]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[4]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[4]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Moderate		Inter Info	[4]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[4]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[4]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[4]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[4]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[4]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[4]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[4]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[4]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[4]
D1583		Tildrakizumab	NA	NA	Moderate		Inter Info	[4]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[4]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[4]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[6], [4]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[4]
D1685		Vedolizumab	NA	NA	Moderate		Inter Info	[4]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[4]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[4]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[4]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[4]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[4]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[6], [4]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[4]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[4]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[4]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[4]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[4]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[4]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[4]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[4]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[4]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[4]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[6], [4]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[4]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[4]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[6], [4]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[4]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[4]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[4]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[4]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[6], [4]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[4]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[4]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[4]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[4]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[4]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[6], [4]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[4]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[4]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[4]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[4]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[4]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[4]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[4]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[4]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[4]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[4]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[4]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[4]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[4]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[4]
D1093		Muromonab	NA	NA	Moderate		Inter Info	[6], [4]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[4]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[4]
D1111		Natalizumab	NA	NA	Moderate		Inter Info	[4]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[4]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[4]
D1168		Olaratumab	NA	NA	Moderate		Inter Info	[4]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[6], [4]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[4]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[4]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[6], [4]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[4]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[4]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[4]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[4]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[4]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[4]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[4]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[4]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[4]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[4]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[4]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[4]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[4]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[4]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[4]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[4]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[4]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[6], [4]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[4]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[6], [4]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[4]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[4]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[4]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[6], [4]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[4]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[4]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[6], [4]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[4]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[4]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[4]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[4]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[4]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[6], [4]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[4]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[4]
	Increased risk of hypocalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[3], [4]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[9], [10], [11]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[3], [1], [5]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[1], [7]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[8]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[3], [1], [5]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[3], [1], [5]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[3], [1], [5]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[3], [1], [5]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[3], [1], [5]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
5	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
6	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
7	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
8	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
9	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
10	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
11	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]

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