Details of Drug

Drug General Information (ID: D0420)
Drug Name	Dapsone (topical)
Drug Type	Small molecule
Drug Synonymous	Aczone; Atrisone; Avlosulfon; Avlosulfone; Avlosulphone; Avsulfor; Croysulfone; Croysulphone; DADPS; DDS; Dapson; Dapsona; Dapsonum; Diaminodifenilsulfona; Diaminodiphenylsulfone; Diaphenylsulfon; Diaphenylsulfone; Diaphenylsulphon; Diaphenylsulphone; Diphenasone; Diphone; Disulone; Dubronax; Dubronaz; Dumitone; Eporal; Novophone; Protogen; Sulfadione; Sulfona; Sulfonyldianiline; Sulphadione; Sulphonyldianiline; Tarimyl; Udolac; Araldite HT; D SS; Diaminodifenilsulfona [Spanish]; Diaminodiphenyl sulfone;Fatol Brand of Dapsone; Metabolite C; Orsade Brand of Dapsone; Sulfone ucb; Sumicure S; Araldite HT 976; F 1358; HT 976; HY 976; Hardener HT 976; W R 448; WR 448; ALBB-005917; AZT + Dapsone cominbation; Aczone (TN); DDS (pharmaceutical); DDS, diaphenylsulfone; DDS, pharmaceutical; DSS (VAN); Dapsoderm-X; Dapson-Fatol; Dapsona [INN-Spanish]; Dapsone (USP); Dapsone [USAN:BAN]; Dapsonum [INN-Latin];Diamino-diphenyl sulphone; Diaphenylsulfone (JAN); IN-201; Mex-America Brand of Dapsone; P-Aminophenyl sulfone; Sulfanona-mae; Sulfon-mere; Sulfona-MAE; Sulphon-mere; Bis(4-aminophenyl) sulfone; Bis(4-aminophenyl)sulfone; Bis(4-aminophenyl)sulphone; Bis(p-aminophenyl) sulfone; Bis(p-aminophenyl)sulphone; Di(4-aminophenyl) sulfone; Di(4-aminophenyl)sulfone; Di(4-aminophenyl)sulphone; Di(p-aminophenyl) sulfone; Di(p-aminophenyl)sulphone; P,p-Diaminodiphenyl sulphone; P,p-Sulfonylbisbenzamine; P,p-Sulfonylbisbenzenamine; P,p-Sulphonylbisbenzamine; P,p-Sulphonylbisbenzenamine; P,p-Sulphonyldianiline; N, N'-Diphenyl sulfondiamide; N,N'-Diphenyl sulfondiamide; P, p'-Sulfonyldianiline; P,p'-Diaminodiphenyl sulfone; P,p'-sulfonyldianiline; Diamino-4,4'-diphenyl sulfone; Diamino-4,4'-diphenyl sulphone; Sulfone, 4,4'-Diaminophenyl; (4-sulfanilylphenyl)amine; 1,1'-Sulfonylbis(4-aminobenzene); 1,1'-Sulfonylbis[4-aminobenzene]; 1,1'-Sulphonylbis(4-aminobenzene); 4,4' Diaminophenyl Sulfone; 4,4'-Dapsone; 4,4'-Diaminodiphenyl sulfone; 4,4'-Diaminodiphenyl suphone; 4,4'-Diaminodiphenylsulfone; 4,4'-Sulfonylbisaniline; 4,4'-Sulfonylbisbenzamine; 4,4'-Sulfonylbisbenzenamine; 4,4'-Sulfonyldianiline;4,4'-Sulfonyldianiline (Dapsone); 4,4'-Sulphonylbisbenzamine; 4,4'-Sulphonylbisbenzenamine; 4,4'-Sulphonyldianiline; 4,4'-diaminophenyl sulfone; 4,4-Diaminodifenylsulfon; 4,4-Diaminodifenylsulfon [Czech]; 4,4-Sulfonyldianiline; 4-(4-aminophenyl)sulfonylaniline; 4-Aminop henyl sulfone; 4-Aminophenyl sulfone; 4-Aminophenylsulfone; 4-[(4-aminobenzene)sulfonyl]aniline; 4-[(4-aminophenyl)sulfonyl]aniline Click to Show/Hide
Disease Class	CA40: Pneumonia
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H12N2O2S
InChI	1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChIKey	MQJKPEGWNLWLTK-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
External Link
	Pubchem ID	2955
	CAS Number	80-08-0
	CHEBI ID	4325
	TTD ID	D0MA9N
	INTEDE ID	DR0415

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM022 CYP450 enzyme induction BM071 Increased risk of methemoglobinemia
Relation Graph

Full list of drugs interacting with Dapsone (topical)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[7], [11], [12]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[7], [11], [12]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[7], [11], [12]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[7], [11], [12]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[7], [11], [12]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[7], [11], [12]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[7], [11], [12]
D0194		Bosentan	C27H29N5O6S	104865	Minor		Inter Info	[7], [11], [12]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[7], [11], [12]
D0300		Cenobamate	C10H10ClN5O2	11962412	Minor		Inter Info	[7], [11], [12]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Minor		Inter Info	[7], [11], [12]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[7], [11], [12]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[7], [11], [12]
D0555		Elagolix	C32H30F5N3O5	11250647	Minor		Inter Info	[7], [11], [12]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[7], [11], [12]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Minor		Inter Info	[7], [11], [12]
D0628		Etravirine	C20H15BrN6O	193962	Minor		Inter Info	[7], [11], [12]
D0639		Felbamate	C11H14N2O4	3331	Minor		Inter Info	[7], [11], [12]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[7], [11], [12]
D0741		Griseofulvin	C17H17ClO6	441140	Minor		Inter Info	[7], [11], [12]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[7], [11], [12]
D0953		Lorlatinib	C21H19FN6O2	71731823	Minor		Inter Info	[7], [11], [12]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Minor		Inter Info	[7], [11], [12]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[7], [11], [12]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[7], [11], [12]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[7], [11], [12]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[7], [11], [12]
D1198		Oxcarbazepine	C15H12N2O2	34312	Minor		Inter Info	[7], [11], [12]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[7], [11], [12]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Minor		Inter Info	[7], [11], [12]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[7], [11], [12]
D1274		Phenylbutazone	C19H20N2O2	4781	Minor		Inter Info	[7], [11], [12]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[7], [11], [12]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[7], [11], [12]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[7], [11], [12]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[7], [11], [12]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[7], [11], [12]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[7], [11], [12]
D1401		Rifapentine	C47H64N4O12	135403821	Minor		Inter Info	[7], [11], [12]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[7], [11], [12]
D1493		Somapacitan	C54H95N13O20S2	129894493	Minor		Inter Info	[7], [11], [12]
D1495		Somatrem	C43H72N14O14	5487805	Minor		Inter Info	[7], [11], [12]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[7], [11], [12]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Minor		Inter Info	[7], [11], [12]
D1538		Tazemetostat	C34H44N4O4	66558664	Minor		Inter Info	[7], [11], [12]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[7], [11], [12]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[7], [11], [12]
D1494		Somatotropin	NA	NA	Minor		Inter Info	[7], [11], [12]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[7], [11], [12]
Pharmacodynamic additive effects
	Increased risk of methemoglobinemia					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[1], [2], [3]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[4], [5], [6]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[4], [7]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[4], [7]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[8], [9], [10]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[4], [7]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[8], [9], [10]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[8], [9], [10]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[8], [9], [10]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[4], [7]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[4], [7]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[8], [9], [10]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[8], [9], [10]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[4], [7]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[4], [7]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [7]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[8], [9], [10]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[4], [7]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[8], [9], [10]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[4], [7]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[4], [7]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[4], [7]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[4], [7]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[4], [7]
D1530		Tafenoquine	C24H28F3N3O3	115358	Moderate		Inter Info	[4], [7]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[8], [9], [10]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[8], [9], [10]

References
1	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
2	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
3	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
4	Cerner Multum, Inc. "Australian Product Information.".
5	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
6	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
7	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
10	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
11	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
12	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.

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