Details of Drug

Drug General Information (ID: D0367)
Drug Name	Clotrimazole
Drug Type	Small molecule
Drug Synonymous	Canesten; Canestene; Canestine; Canifug; Chlotrimazole; Cimitidine; Clomatin; Clotrimaderm; Clotrimazol; Clotrimazolum; Clotrimeizol; Cutistad; Empecid; Esparol; FemCare; Gynix; Kanesten; Klotrimazole; Lotrimax; Lotrimin; Monobaycuten; Mycelax; Mycelex; Mycofug; Mycosporin; Mykosporin; Nalbix; Pedisafe; Rimazole; Stiemazol; Tibatin; Trimysten; Canesten Cream; Canesten Solution; Clotrimazole Schering Brand; Desamix F; Fem Care; Gyne lotrimin; Lotrimin AF Cream; Lotrimin AF Lotion; Lotrimin AF Solution; Lotrimin Af; Lotrimin Cream; Lotrimin Lotion; Lotrimin Solution; Mycelex Cream; Mycelex G; Mycelex OTC; Mycelex Solution; Mycelex Troches; Mycelex Twin Pack; Myclo Cream; Myclo Solution; Myclo Spray Solution; Schering Brand of Clotrimazole; B 5097; Bay b 9057; Bayer Brand 1 of Clotrimazole; Bayer Brand 2 of Clotrimazole; C 6019; FB 5097; FB b 5097; Mycelex 7; Trivagizole 3; Bay-B 5097; Candid Vaginal (TN); Candinil (TN); Canesten (TN); Canesten 1-Day Therapy; Canesten 3-Day Therapy; Canesten 6-Day Therapy; Clobrate VT (TN); Clotrimazol [INN-Spanish]; Clotrimazolum [INN-Latin]; DRG-0072; Gino-Lotremine; Gyne-Lotrimin; Gyne-Lotrimin 3; Gyne-Lotrimin 3 Combination Pack; Gyne-Lotrimin Combination Pack; Lotrimin (TN); Lotrimin AF Jock-Itch Cream; Mono-baycuten; Mycelex (TN); Mycelex-7; Mycelex-7 Combination Pack; Mycelex-G; Mycelex: MycosporinRimazole; Myclo-Gyne; Neo-Zol Cream; Pan-Fungex; Cancap-VT (TN); Candid - V Gel (TN); Canesten 1-Day Cream Combi-Pak; Canesten Combi-Pak 1-Day Therapy; Canesten Combi-Pak 3-Day Therapy; Clotrimazole (JP15/USP/INN); Clotrimazole [USAN:INN:BAN:JAN]; (Chlorotrityl)imidazole; 1-(o-Chlorotrityl)imidazole Click to Show/Hide
Disease Class	1F29-1F2F: Fungal infection
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H17ClN2
InChI	1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	VNFPBHJOKIVQEB-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
External Link
	Pubchem ID	2812
	CAS Number	23593-75-1
	CHEBI ID	3764
	TTD ID	D09GOS
	INTEDE ID	DR0362
	VARIDT ID	DR00574

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Clotrimazole
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0656		Fexofenadine	C32H39NO4	3348	Minor		Inter Info	[416], [417]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 201
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[15], [16], [17]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[43], [44], [45]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[46]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[47]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[48]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[49]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[20], [50], [51], [52], [53], [54], [13]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[55], [56], [57], [58], [59]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[43], [44]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[60], [61], [62]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[20], [66]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[67], [68]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[68]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[71], [20], [72]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[20], [60], [73]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[75], [76], [77]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[78]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[75], [76], [77]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[18], [19], [79], [20], [80], [22], [81], [25], [82], [83], [84], [85], [86], [87], [88], [89], [90], [26], [27], [29], [30], [91], [31], [32], [34], [37], [40], [42], [92], [93], [94]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[96]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[108], [109], [110]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[111]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[112]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[113], [114]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[115]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[63], [60], [116], [117]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[118], [119], [120], [121], [22], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[60], [145], [114]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[146], [147]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[148]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[149]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[60], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [126]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[60], [160]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[60], [161]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[163], [164]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[165]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[60], [166]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[20], [60], [168]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[169], [20], [60], [170], [171], [172], [173], [174], [175], [176], [177], [178], [163], [164], [179], [180]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[169], [20], [60]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[181]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[182]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[183]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[60], [185]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[186]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[60], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [126]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[187], [188], [189], [190], [191], [192], [193], [194], [195]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[196], [197], [198], [22], [199], [200], [201], [27], [126], [202]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[204]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[205]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[207], [208], [210]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[211]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[212]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[20], [60], [213]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[214], [114]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[215]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[216], [217], [218], [27], [29], [30], [53], [219], [32]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[207], [208], [210]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[220], [221], [222], [22], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [126], [233], [234], [235], [236]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[237]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[238]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[239]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[242]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[243]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[244]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[222], [230], [236]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[220], [221], [222], [22], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [126], [233], [234], [235], [236]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[207], [208], [210]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[207], [208], [210]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[207], [208], [210]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[245], [246], [247], [60], [22], [248], [249]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[207], [208], [210]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[250]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[251], [114]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[252]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[253]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[146], [147]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[254]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[255], [256]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[60], [257]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[258]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[259], [260]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[60], [261]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[262], [114]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[264]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[218]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[265], [266]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[267]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[268]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[20], [60], [269]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[270]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[60], [271]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[272]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[273]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[20], [60], [274], [114]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[275]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[276]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[277]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[207], [208], [210]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [32], [291], [292], [293], [294], [295]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[222], [230], [236]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[60], [297]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[299]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[63], [20], [60]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[207], [208], [210]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[300]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[301]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[302], [303], [20], [304], [305], [306], [307], [308]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[302], [303], [20]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[60], [309]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[310], [311]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[312]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[60], [317]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[318]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[22], [319], [320], [321], [126]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[322]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[323]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[324]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[207], [208], [210]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[325], [326]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[327], [328], [329], [330], [331], [332], [333], [334], [335]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[60], [126]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[20], [60], [336], [337], [338], [339], [340], [341], [342], [343], [344]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[348], [349], [350], [351], [352], [353], [354]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[20], [60], [355]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[20], [356], [60], [357]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[20], [358]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[20], [60], [359]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[60], [360]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[60], [361]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[362]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[363]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[60], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [126]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[364]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[60], [61], [365]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[20], [366]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[367]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[368], [369], [370], [371]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[372]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[163], [164]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[373]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[60], [374]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[377], [378]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[379]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[118], [119], [120], [121], [22], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[381]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[382]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[383], [114]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[20], [60], [384]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[20], [60], [385]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[138], [139], [140], [30], [141], [142], [143], [144]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[386]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[387]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[388], [389], [390], [391], [392], [393], [394]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[395], [396]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[206], [207], [208], [32], [209], [210]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[397]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[398]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[60], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [126]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[222], [230], [236]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[399], [400], [401], [402]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[403], [404]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[408]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[20], [409], [410]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[411]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[412], [371], [413], [414]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[415]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[403], [404]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[418]
D0948		Lopinavir	C37H48N4O5	92727	Minor		Inter Info	[60], [419], [420]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[421]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[20], [409], [410]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[422]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[423]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[424], [425], [426], [427], [428], [429], [430]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[60], [431]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[432]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[60], [433]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[434], [435], [436], [437]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[95]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[63], [64], [65]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[69]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[70]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[74]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[63], [64], [65]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[97], [98], [99], [20], [60], [100], [101], [102], [103], [104], [105], [106], [107]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[97], [98], [99], [20], [60], [100], [101], [102], [103], [104], [105], [106], [107]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[162]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[167]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[97], [98], [99], [20], [60], [100], [101], [102], [103], [104], [105], [106], [107]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[60], [184]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[203]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[240], [241]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[263]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[60], [296]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[298]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[313], [314], [315], [316]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[20], [60], [345], [346], [347]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[375], [376]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[60], [380]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[313], [314], [315], [316]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[313], [314], [315], [316]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[97], [98], [99], [20], [60], [100], [101], [102], [103], [104], [105], [106], [107]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0075		Amphotericin B	C47H73NO17	5280965	Minor		Inter Info	[405], [406], [407]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Minor		Inter Info	[405], [406], [407]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Minor		Inter Info	[405], [406], [407]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Minor		Inter Info	[405], [406], [407]

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103	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
104	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
105	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
106	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
107	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
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109	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
110	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
111	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
112	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
113	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
114	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
115	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
116	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
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125	Product Information. Halcion (triazolam). Pharmacia and Upjohn, Kalamazoo, MI.
126	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
127	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
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145	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
146	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
147	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
148	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
149	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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160	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
161	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
162	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
163	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
164	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
165	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
166	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
167	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
168	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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179	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
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181	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
182	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
183	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
184	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
185	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
186	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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202	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
203	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
204	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
205	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
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211	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
212	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
213	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
214	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
215	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
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218	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
219	Product Information. Valium (diazepam). Roche Laboratories, Nutley, NJ.
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231	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
232	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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237	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
238	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
239	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
240	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
241	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
242	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
243	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
244	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
245	Alderman CP, Gebauer MG, Gilbert AL, Condon JT "Possible interaction of zopiclone and nefazodone." Ann Pharmacother 35 (2001): 1378-80. [PMID: 11724087]
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248	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
249	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
250	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
251	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
252	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
253	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
254	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
255	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
256	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
257	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
258	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
259	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
260	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
261	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
262	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
263	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
264	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
265	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
266	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
267	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
268	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
269	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
270	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
271	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
272	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
273	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
274	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
275	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
276	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
277	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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363	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
364	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
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387	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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407	Product Information. Ambisome (amphotericin B liposomal) Nexstar Pharmaceuticals, San Dimas, CA.
408	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
409	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
410	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
411	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
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422	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
423	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
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432	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
433	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
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435	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
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